Anatomical and physiological differences between various species used in studies on the harmacokinetics and toxicology of xenobiotics. A review of literature

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This page provides a description and a link to a "Anatomical and physiological differences between various species used in studies on the harmacokinetics and toxicology of xenobiotics. A review of literature" guidance document that can be used for exposure assessment.

Short description

An inventory was made of relevant physiological and anatomical characteristics of various species most commonly used in studies on pharmacokinetics and toxicology of oral exposure to xenobiotics. The species studied were: the human, mouse, rat, rabbit, dog, (mini)pig and monkey. The anatomical and physiological characteristics of the different compartments of the gastrointestinal tract, mouth, stomach and small intestine, and of the bile and metabolism in liver and small intestine were reviewed. This report is primarily meant as a review for researchers using animal models to study pharmacokinetics and toxicokinetics of xenobiotics, and for risk assessors on pharmacokinetics and toxicokinetics.

Link

http://www.rivm.nl/bibliotheek/rapporten/623860010.html

Keywords

species, anatomical physiological characteristics, pharmacokinetics, toxicokinetics, animal models