Difference between revisions of "ERF of PCB on cancer"

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m (Variable:Exposure-response of PCB intake for cancer risk in adults moved to ERF of PCB on cancer: Variables belong to main namespace. Title made more precise.)
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'''Scope'''<br>
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== '''Scope''' ==
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'''Exposure-response of PCB intake for cancer risk in adults''' describes the quantitative relationship between exposure to PCBs via fish ingestion and the lifetime risk of cancer in adults.
 
  
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== Definition ==
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'''ERF of PCB on cancer '''describes the quantitative relationship between exposure to <!--[if gte mso 10]>
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Exposure-response of PCB intake for cancer risk in adults is indexed by variable age. It applies to the last two age categories.
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<![endif]--><span>polychlorinated biphenyls</span> (PCBs) and cancer risk in adults.  
  
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=== Causality ===
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== Definition  ==
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List of parents:
 
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* None
 
  
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=== Data ===
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ERF of PCB on cancer indexed by variable age. It applies to the last two age categories, i.e. 18-55yr, 55yr+.
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List of data files or sources:
 
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* item 1
 
  
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=== Formula ===  
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=== Causality<br>  ===
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Analytica_id:
 
  
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<anacode></anacode>
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=== Data  ===
  
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=== Unit ===
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The U.S. Environmental Protection Agency (US EPA) reccomends using cancer slope factors (CSFs) when evaluating potential cancer risks of PCB mixtures.<ref>IRIS. US EPA. http://www.epa.gov/iris/subst/0294.htm</ref> There are three tiers of CSFs for environmentsl PCBs that depend on the exposure pathway. These are: high risk and persistence, low risk and persistence, lowest risk and persistence. In each of these tiers EPA reports central and upper bound estimate of CSF. In general, central estimate slope factors are used to estimate a typical individual’s risk while upper-bound slope assure that this risk is not likely to be underestimated if the underlying model is correct.
  
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== Result ==
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According to the US EPA exposures via food chain are associated with the highest risk and persistence. Therefore CSFs from the first tier are reccomended to be used when estimating cancer risks from food chain pathways. &nbsp; <br>
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=== Formula<br>  ===
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=== Unit  ===
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(mg/kg bw/d)<sup>-1</sup>
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== Result ==
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{| border="1"
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|-
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|
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| '''Upper bound slope factor'''
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| '''Central-estimate slope factor'''
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|-
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| '''High risk and persistence'''
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| 2.0
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| 1.0
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|-
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| '''Low risk and persistence'''
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| 0.4
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| 0.3
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|-
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| '''Lowest risk and persistence'''
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| 0.07
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| 0.04
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|}
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==  ==
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== References  ==
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<references />

Revision as of 13:26, 20 October 2008

Scope

ERF of PCB on cancer describes the quantitative relationship between exposure to polychlorinated biphenyls (PCBs) and cancer risk in adults.

Definition

ERF of PCB on cancer indexed by variable age. It applies to the last two age categories, i.e. 18-55yr, 55yr+.

Causality

Data

The U.S. Environmental Protection Agency (US EPA) reccomends using cancer slope factors (CSFs) when evaluating potential cancer risks of PCB mixtures.[1] There are three tiers of CSFs for environmentsl PCBs that depend on the exposure pathway. These are: high risk and persistence, low risk and persistence, lowest risk and persistence. In each of these tiers EPA reports central and upper bound estimate of CSF. In general, central estimate slope factors are used to estimate a typical individual’s risk while upper-bound slope assure that this risk is not likely to be underestimated if the underlying model is correct.

According to the US EPA exposures via food chain are associated with the highest risk and persistence. Therefore CSFs from the first tier are reccomended to be used when estimating cancer risks from food chain pathways.  

Formula

Unit

(mg/kg bw/d)-1

Result

Upper bound slope factor Central-estimate slope factor
High risk and persistence 2.0 1.0
Low risk and persistence 0.4 0.3
Lowest risk and persistence 0.07 0.04

References

  1. ↑ IRIS. US EPA. http://www.epa.gov/iris/subst/0294.htm
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