Difference between revisions of "ERF of dioxin on dental aberrations"
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| − | + | <accesscontrol>beneris</accesscontrol> | |
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'''Scope'''<br> | '''Scope'''<br> | ||
| − | '''The variable''' describes | + | '''The variable''' describes developmental defects in human teeth as enamel defects of all human teeth. |
== Definition == | == Definition == | ||
=== Causality === | === Causality === | ||
| + | |||
List of parents: | List of parents: | ||
| − | * | + | *[[Variable:Intake of PCBs from fish]] |
| + | *[[Variable:Intake of PCDD/Fs from fish]] | ||
| + | |||
=== Data === | === Data === | ||
| − | |||
| − | |||
=== Formula === | === Formula === | ||
| − | |||
| − | + | === Unit === | |
| − | === | + | Relative risk (risk %) |
| + | |||
| + | == Result <sup><ref>Alaluusua, S., Calderara, P., Gerthoux, P.M., Lukinmaa, P-L., Kovero, O., Needham, L., Patterson, D.G., Tuomisto, J., and Mocarelli, P. (2004) Developmental dental aberrations after the dioxin accident in Seveso. Environ Health Perspect. 112, 1313-8.</ref><ref>Kattainen, H., Tuukkanen, J., Simanainen, U., Tuomisto, J.T., Kovero, O., Lukinmaa, P-L., Alaluusua, S., Tuomisto, J., and Viluksela, M. (2001) In utero/lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure impairs molar tooth development in rats. Toxicol Appl Pharmacol. 174, 216-24.</ref><ref>Niittynen, M. Tuomisto1, JT., Karjalainen, A., Pekkanen,J. A case study of combining epidemiology and toxicology in environmental health risk assessment: TCDD-induced dental aberrations in humans and rats. (manuscript in prep.)</ref></sup>== | ||
| + | |||
| + | |||
| + | {|{{prettytable}} | ||
| + | ! Exposure cases | ||
| + | ! Observation n | ||
| + | ! Cases | ||
| + | ! Serum 2,4,7,8-TCDD concn. range, pg/g lipid | ||
| + | ! Serum 2,4,7,8-TCDD concn. mean, pg/g lipid | ||
| + | ! Risk % | ||
| + | ! Risk ratio | ||
| + | |----- | ||
| + | | Control | ||
| + | | 49 | ||
| + | | 11 | ||
| + | | 31-226 | ||
| + | | 128.5 | ||
| + | | 22 | ||
| + | | 1 | ||
| + | |----- | ||
| + | | Exposed | ||
| + | | 11 | ||
| + | | 5 | ||
| + | | 238-592 | ||
| + | | 415 | ||
| + | | 45 | ||
| + | | 2.05 | ||
| + | |----- | ||
| + | | Exposed | ||
| + | | 15 | ||
| + | | 9 | ||
| + | | 700-26000 | ||
| + | | 3000 | ||
| + | | 60 | ||
| + | | 2.73 | ||
| + | |} | ||
| + | |||
| + | == References == | ||
| − | + | <references/> | |
Revision as of 18:03, 1 November 2007
<accesscontrol>beneris</accesscontrol>
Scope
The variable describes developmental defects in human teeth as enamel defects of all human teeth.
Definition
Causality
List of parents:
Data
Formula
Unit
Relative risk (risk %)
Result [1][2][3]
| Exposure cases | Observation n | Cases | Serum 2,4,7,8-TCDD concn. range, pg/g lipid | Serum 2,4,7,8-TCDD concn. mean, pg/g lipid | Risk % | Risk ratio |
|---|---|---|---|---|---|---|
| Control | 49 | 11 | 31-226 | 128.5 | 22 | 1 |
| Exposed | 11 | 5 | 238-592 | 415 | 45 | 2.05 |
| Exposed | 15 | 9 | 700-26000 | 3000 | 60 | 2.73 |
References
- ↑ Alaluusua, S., Calderara, P., Gerthoux, P.M., Lukinmaa, P-L., Kovero, O., Needham, L., Patterson, D.G., Tuomisto, J., and Mocarelli, P. (2004) Developmental dental aberrations after the dioxin accident in Seveso. Environ Health Perspect. 112, 1313-8.
- ↑ Kattainen, H., Tuukkanen, J., Simanainen, U., Tuomisto, J.T., Kovero, O., Lukinmaa, P-L., Alaluusua, S., Tuomisto, J., and Viluksela, M. (2001) In utero/lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure impairs molar tooth development in rats. Toxicol Appl Pharmacol. 174, 216-24.
- ↑ Niittynen, M. Tuomisto1, JT., Karjalainen, A., Pekkanen,J. A case study of combining epidemiology and toxicology in environmental health risk assessment: TCDD-induced dental aberrations in humans and rats. (manuscript in prep.)
