Difference between revisions of "ERF of dioxin on cancer"
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| − | '''ERF of dioxin on cancer '''describes the quantitative relationship between exposure to polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) | + | '''ERF of dioxin on cancer '''describes the quantitative relationship between exposure to polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) and cancer risk in adults.<br><!--[if gte mso 10]> |
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== Definition == | == Definition == | ||
Revision as of 12:41, 20 October 2008
Scope
ERF of dioxin on cancer describes the quantitative relationship between exposure to polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) and cancer risk in adults.
Definition
Exposure-response of PCDD/F intake for cancer risk in adults is indexed by variable age. It applies to the last two age categories, i.e. 18-55yr and 55yr+.
Causality
Data
The U.S. Environmental Protection Agency (US EPA) calculated an oral cancer slope factor (CSF) for 2,3,7,8 - TCDD (the most toxic dioxin compound). This CFS equals to 156000 (mg/kg bw-d)-1 and represents the upper 95th percentile estimate of the probability of developing cancer per unit intake of chemical over a lifetime. [1]
Formula
Unit
(mg/kg bw/d)-1
Result
156000
References
- ↑ US EPA 2000. Guidance for assessing chemical contaminant data for use in fish advisories. Volume 1: Fish sampling and analysis, 3rd edition. http://www.epa.gov/waterscience/fish/advice/volume1/
