Difference between revisions of "Variable:Assessment:Combining dioxin epidemiology and toxicology"
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| + | * [[Variable:Exposure-response function for tooth defect caused by TCDD in studies with rats and Seveso children|Study-specific E-R function]] | ||
| + | * [[Variable:Exposure-response function for tooth defect caused by TCDD for rats and children|Species-specific E-R function]] | ||
| + | * [[Variable:Exposure-response function for tooth defect caused by TCDD for Finnish children|E-R function for children]] | ||
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Importance | Importance | ||
Revision as of 20:46, 3 January 2008
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Contents
Scope
Purpose
The purpose of the assessment is to develop a systematic method to combine toxicological and epidemiological information for human exposure-response functions. This method is then tested for a case study of dioxin-induced tooth defects in rats and humans.
Boundaries
Scenarios
Intended users
Toxicologists, epidemiologists, and risk assessors who need to utilise both toxicological and epidemiological data when estimating human health effects.
Participants
- Juha Pekkanen
- Jouni Tuomisto
- Marjo Niittynen
- Anna Karjalainen
Definition
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Variables
Importance
1: Not so important
2: In-between
3: Very important
| Possible corrections | Importance (1-3) in different study types | |
|---|---|---|
| Animal, experimental | Human, non-experimental | |
| Single study | ||
| Shape of E-R curve in measured range | 2 | 2: |
| Measurement error in treatment | 1: Not all feed is eaten? | 3: Information bias |
| Measurement error in outcome | 1: Coding, detection errors | 1: Information bias |
| Systematic differences in other exposures | 1: Secondary effects due to e.g. weight loss | 3: Confounding |
| Selection of participants | ?: Animals to use in analysis | 2: Selection bias |
| Exposure-response (general) | ||
| Shape of E-R curve outside measured range | 3: Low dose extrapolation | 2: In occupational studies |
| Pooling studies | ||
| Not correct dose pattern | 1: not correct window of exposure? | 2: Not life time, correct window of exposure |
| Heterogeneity between studies | ||
| Publication bias | ||
| Not correct outcome | 2: all tumours vs cancer | 1: |
| Extrapolation to humans | ||
| Not correct outcome | 2: all tumours vs cancer | 1: |
| Not correct pharmacodynamics | 3: animal-to-human | 1: different race, age |
| Not correct pharmacokinetics (dose scaling, exposure route) | 3: animal-to-human | 1: different race, age |
| Within human variation | 3: | 2: |
| Estimated based on data outside the selected epi+tox studies | ||
| Plausibility | ||
