Difference between revisions of "Talk:Benefit-risk assessment of fish consumption for Beneris"

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I. List of variables (nodes) in the Bayesian Belief Network for the fish case study in the BENERIS project

Nutritional effectors:

• * fish consumption in age group [0,2yr), • * fish consumption in age group [2,18yr), • * fish consumption in age group [18,55yr), • * fish consumption in age group [55+ yr), • * concentration of PCDD/Fs in fish, • * concentration of PCBs in fish, • * concentration of omega-3 fatty acids in fish, • * concentration of methyl mercury in fish, • * concentration of selenium in fish, • * concentration of iodine in fish, • * exposure to PCDD/Fs from fish in age group [0,2yr), • Exposure to (=intake of) pollutant/nutrient from fish for age group i will be calculated as the product of fish consumption in age group i and concentration of pollutant/nutrient in fish. This will be further divided by the body weight to express the exposure per kg of body mass. • * exposure to PCDD/Fs from fish in age group [2,18yr), • * exposure to PCDD/Fs from fish in age group [18,55yr), • * exposure to PCDD/Fs from fish in age group [55+ yr), • * exposure to PCBs from fish in age group [0,2yr), • * exposure to PCBs from fish in age group [2,18yr), • * exposure to PCBs from fish in age group [18,55yr), • * exposure to PCBs from fish in age group [55+ yr), • * exposure to omega-3 fatty acids from fish in age group [0,2yr), • * exposure to omega-3 fatty acids from fish in age group [2,18yr), • * exposure to omega-3 fatty acids from fish in age group [18,55yr), • * exposure to omega-3 fatty acids from fish in age group [55+ yr), • * exposure to methyl mercury from fish in age group [0,2yr), • * exposure to methyl mercury from fish in age group [2,18yr), • * exposure to methyl mercury from fish in age group [18,55yr), • * exposure to methyl mercury from fish in age group [55+ yr), • * exposure to selenium from fish in age group [0,2yr), • * exposure to selenium from fish in age group [2,18yr), • * exposure to selenium from fish in age group [18,55yr), • * exposure to selenium from fish in age group [55+ yr), • * exposure to iodine from fish in age group [0,2yr), • * exposure to iodine from fish in age group [2,18yr).

Personal effectors:

• * body weight in age group [0,2yr), • * body weight in age group [2,18yr), • * body weight in age group [18,55yr), • * body weight in age group [55+ yr), • * socioeconomic status (parental educational level-number of years of schooling received) in age group [0,2yr), • * socioeconomic status (number of years of schooling received) in age group [2,18yr), • * socioeconomic status (number of years of schooling received) in age group [18,55yr), • * socioeconomic status (number of years of schooling received) in age group [55+ yr), • * exposure to nicotine via active smoking in age group [2,18yr), • * exposure to nicotine via active smoking in age group [18,55yr), • * exposure to nicotine via active smoking in age group [55+ yr).

Indicators/ Health endpoints:

• * change in IQ in children between 0 and 2 years of age, • * change in IQ in children between 2 and 18 years of age, • * change in IQ in children (between 0 and 18 years of age), • * risk of dental aberrations in children between 0 and 2 years of age, • * risk of dental aberrations in children between 2 and 18 years of age, • * risk of dental aberrations in children (between 0 and 18 years of age), • * the (remaining) lifetime risk of cancer in adults between 18 and 55 years of age, • * the (remaining) lifetime risk of cancer in adults older than 55 years of age, • * the (remaining) lifetime risk of cancer in adults (older than 18 years of age), • * the (remaining) lifetime risk of myocardial infarction in adults between 18 and 55 years of age, • * the (remaining) lifetime risk of myocardial infarction in adults older than 55 years of age, • * the (remaining) lifetime risk of myocardial infarction in adults (older than 18 years of age).

II. Data requirements for the BBN:

In order to quantify non-functional nodes of the Bayesian Belief Network for the fish case study the following data is needed:

• * distribution of the fish consumption in age group [0,2yr), • * distribution of the fish consumption in age group [2,18yr), • * distribution of the fish consumption in age group [18,55yr), • * distribution of the fish consumption in age group [55+ yr), • * distribution of the concentration of PCDD/Fs in fish, • * distribution of the concentration of PCBs in fish, • * distribution of the concentration of omega-3 fatty acids in fish, • * distribution of the concentration of methyl mercury in fish, • * distribution of the concentration of selenium in fish, • * distribution of the concentration of iodine in fish, • * distribution of the body weight in age group [0,2yr), • * distribution of the body weight in age group [2,18yr), • * distribution of the body weight in age group [18,55yr), • * distribution of the body weight in age group [55+ yr), • * distribution of socioeconomic status (parental educational level-number of years of schooling received) in age group [0,2yr), • * distribution of socioeconomic status (number of years of schooling received) in age group [2,18yr), • * distribution of socioeconomic status (number of years of schooling received) in age group [18,55yr), • * distribution of socioeconomic status (number of years of schooling received) in age group [55+ yr), • * distribution of the nicotine intake via active smoking in age group [2,18yr), • * distribution of the nicotine intake via active smoking in age group [18,55yr), • * distribution of the nicotine intake via active smoking in age group [55+ yr).

In order to quantify functional nodes of the Bayesian belief Network (health risks and benefits) the following information is needed: • * information about percentage of people of the target population in age group [0,2yr), • * information about percentage of people of the target population in age group [2,18yr), • * information about percentage of people of the target population in age group [18,55yr), • * information about percentage of people of the target population in age group [55+ yr), • * information about percentage of people in age group [0,2yr) and in age group [2,18yr) in a subpopulation of the target population in age group [0,18yr), • * information about percentage of people in age group [18,55yr) and in age group [55+ yr) in a subpopulation of the target population in age group [18+ yr), • * information about the expected lifetime in the target population.

Additional data needed per each health effect considered in the case study:

IQ change age group [0,2yr): • * information about background unit change in IQ in age group [0,2yr), • * exposure-response of exposure to methyl mercury for IQ change for people in age group [0,2yr), • * exposure-response of exposure to selenium for unit IQ change for people in age group [0,2yr), • * exposure-response of exposure to ω-3 fatty acids for unit IQ change for people in age group [0,2yr), • * exposure-response of exposure to iodine for unit IQ change for people in age group [0,2yr), • * exposure-response of socioeconomic status for unit IQ change for people in age group [0,2yr), • * exposure-response of exposure to methyl mercury and selenium for unit IQ change for people in age group [0,2yr).

IQ change age group [2,18yr): • * information about background unit change in IQ in age group [2,18yr), • * exposure-response of exposure to methyl mercury for IQ change for people in age group [2,18yr), • * exposure-response of exposure to selenium for unit IQ change for people in age group [2,18yr), • * exposure-response of exposure to ω-3 fatty acids for unit IQ change for people in age group [2,18yr), • * exposure-response of exposure to iodine for unit IQ change for people in age group [2,18yr), • * exposure-response of socioeconomic status for unit IQ change for people in age group [2,18yr), • * exposure-response of exposure to nicotine via active smoking for unit IQ change for people in age group [2,18yr), • * exposure-response of exposure to methyl mercury and selenium for unit IQ change for people in age group [2,18yr).

Developmental dental aberration risk age group [0,2yr): • * information about background incidence of teeth defects among people in age group [0,2yr), • * exposure-response of exposure to PCDD/Fs for teeth defects risk for people in age group [0,2yr), • * exposure-response of exposure to PCBs for teeth defects risk for people in age group [0,2yr), • * exposure-response of socioeconomic status for teeth defects risk for people in age group [0,2yr).

Developmental dental aberration risk age group [2,18yr): • * information about background incidence of teeth defects among people in age group [2,18yr), • * exposure-response of exposure to PCDD/Fs for teeth defects risk for people in age group [2,18yr), • * exposure-response of exposure to PCBs for teeth defects risk for people in age group [2,18yr), • * exposure-response of socioeconomic status for teeth defects risk for people in age group [2,18yr), • * exposure-response of exposure to nicotine via active smoking for teeth defects risk for people in age group [2,18yr).

Cancer risk age group [18,55yr): • * information about background incidence of cancer in age group [18,55yr), • Incidence of cancer and myocardial infarction is defined as a probability of having a disease over person’s lifetime. • * exposure-response of exposure to PCDD/Fs for lifetime cancer risk for people in age group [18,55yr), • * exposure-response of exposure to PCBs for lifetime cancer risk for people in age group [18,55yr), • * exposure-response of socioeconomic status for lifetime cancer risk for people in age group [18,55yr), • * exposure-response of exposure to nicotine via active smoking for lifetime cancer risk for people in age group [18,55yr).

Cancer risk age group [55+ yr): • * information about background incidence of cancer in age group [55+ yr), • * exposure-response of exposure to PCDD/Fs for lifetime cancer risk for people in age group [55+ yr), • * exposure-response of exposure to PCBs for lifetime cancer risk for people in age group [55+ yr), • * exposure-response of socioeconomic status for lifetime cancer risk for people in age group [55+ yr), • * exposure-response of exposure to nicotine via active smoking for lifetime cancer risk for people in age group [55+ yr).

Myocardial infarction risk age group [18,55yr): • * information about background incidence of myocardial infarction in age group [18,55yr), • * exposure-response of exposure to methyl mercury for lifetime myocardial infarction risk for people in age group [18,55yr), • * exposure-response of exposure to selenium for lifetime myocardial infarction risk for people in age group [18,55yr), • * exposure-response of exposure to ω-3 fatty acids for lifetime myocardial infarction risk for people in age group [18,55yr), • * exposure-response of socioeconomic status for lifetime myocardial infarction risk for people in age group [18,55yr), • * exposure-response of exposure to nicotine via active smoking for lifetime myocardial infarction risk for people in age group [18,55yr), • * exposure-response of exposure to methyl mercury and selenium for lifetime myocardial infarction risk for people in age group [18,55yr).

Myocardial infarction risk age group [55+ yr): • * information about background incidence of myocardial infarction in age group [55+ yr), • * exposure-response of exposure to methyl mercury for lifetime myocardial infarction risk for people in age group [55+ yr), • * exposure-response of exposure to selenium for lifetime myocardial infarction risk for people in age group [55+ yr), • * exposure-response of exposure to ω-3 fatty acids for lifetime myocardial infarction risk for people in age group [55+ yr), • * exposure-response of socioeconomic status for lifetime myocardial infarction risk for people in age group [55+ yr), • * exposure-response of exposure to nicotine via active smoking for lifetime myocardial infarction risk for people in age group [55+ yr), • * exposure-response of exposure to methyl mercury and selenium for lifetime myocardial infarction risk for people in age group [55+ yr).