Difference between revisions of "Benefit-risk assessment of fish consumption for Beneris"

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m (Variable:Assessment:Net health effects of fish consumption moved to Benefit-risk assessment of fish consumption for Beneris: Assessments belong nowadays to the main namespace. The name should distinguish this assessment from other fish BRAs, there)
(other assessment pages moved to this page)
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==Scope==
 
==Scope==
  
[[Image:Net_health_effects_of_fish_consumption_31102007_ak.PNG| Net health effects of fish consumption]]
+
Net health effects of fish consumption {{disclink|Decision options/scenarios}}
  
Net health effects of fish consumption
+
===Purpose===
{{disclink|Decision options/scenarios}}
 
  
===Purpose===
+
Net health effects of fish consumption due to intake of beneficial nutrients and constituents and on the other hand, exposure to environmental contaminants taken up by fish. This assessment also evaluates the effects of methyl mercury and omega-3 fatty acids on development of IQ in children.
  
Net health effects of fish consumption due to intake of beneficial nutrients and constituents and on the other hand, exposure to environmental contaminants taken up by fish.
 
 
   
 
   
 
===Boundaries===
 
===Boundaries===
  
 
*Environmental contaminants relevant from the human health point of view and thus included in the assessment are:
 
*Environmental contaminants relevant from the human health point of view and thus included in the assessment are:
**PCDD/Fs
+
**polychlorinated dibenzo-''p''-dioxins and dibenzofurans (PCDD/F)
**PCBs
+
**polychlorinated biphenyls (PCB)
**Hg (as MetHg)
+
**mercury as methyl mercury (MetHg)
*Nutritional constituents relevant from the human health point of view include a wide variety of effects and can be viewed from [[Benefit-risk assessment of fish and related policy options|Benefit-risk assessment of fish and related policy options]] under title "Health consequences attributable to fish consumption". However, readily usable beneficial constituents with quantitative dose-response information available included in the asessment at the moment are:
+
*Nutritional constituents relevant from the human health point of view include a wide variety of effects and can be viewed from [[Benefit-risk assessment of fish and related policy options|Benefit-risk assessment of fish and related policy options]] under title "Health consequences attributable to fish consumption". However, readily usable beneficial constituents with quantitative dose-response information available included in the assessment are:
**fish oils
+
**omega-3 polyunsaturated fatty acids (PUFA)
**omega-3 PUFAs (omega-3 polyunsaturated fatty acids)
+
**iodine (I)
*European subpopulations included in the assessment:
+
**selenium (Se)
 +
*European sub-populations included in the assessment:
 
**Finland
 
**Finland
 
**Ireland
 
**Ireland
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===Scenarios===
 
===Scenarios===
  
BAU-type assessment (business-as-usual assessment), i.e. a burden-of-disease assessment with only one decision scenario.
+
BAU-type assessment (business-as-usual assessment), i.e. a burden-of-disease assessment with only one decision scenario. {{disclink|Decision options/scenarios}}
{{disclink|Decision options/scenarios}}
 
  
 
===Intended users===
 
===Intended users===
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==Definition==
 
==Definition==
 +
 +
[[image:Uninet BBN 30102007 pg zoomed in.PNG]]
  
 
===Decision variables===
 
===Decision variables===
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*[[Variable:Cancer risk in adults]]
 
*[[Variable:Cancer risk in adults]]
 
*[[Variable:Myocardial infarction risk in adults]]
 
*[[Variable:Myocardial infarction risk in adults]]
*
 
*
 
  
  
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|[[Variable:Assessment:Nutritional benefits and risks of PCDD/F exposure of fish consumption in Finnish children and adults]]
 
|[[Variable:Assessment:Nutritional benefits and risks of PCDD/F exposure of fish consumption in Finnish children and adults]]
 
| [[Variable:Domestic fish consumption of a general population]] | [[Variable:Domestic fish consumption of pregnant women]] | [[Variable:Concn. of beneficial nutrients in various fish species]] | [[Variable:Omega-3-fatty acid concn.in various fish species]] |  [[Variable:Exposure-response of PCDD/F intake for dental aberrations risk in children]] | [[Variable:Exposure-response of PCDD/F intake for total cancer risk in adults]] | [[Omega-3 fatty acid beneficial effects on central nervous system development in chidren]] | [[Variable:Omega-3 fatty acid protection against cancer]]
 
| [[Variable:Domestic fish consumption of a general population]] | [[Variable:Domestic fish consumption of pregnant women]] | [[Variable:Concn. of beneficial nutrients in various fish species]] | [[Variable:Omega-3-fatty acid concn.in various fish species]] |  [[Variable:Exposure-response of PCDD/F intake for dental aberrations risk in children]] | [[Variable:Exposure-response of PCDD/F intake for total cancer risk in adults]] | [[Omega-3 fatty acid beneficial effects on central nervous system development in chidren]] | [[Variable:Omega-3 fatty acid protection against cancer]]
 +
|}
 +
 +
 +
[[Image:Valikaavio_RBA_Fish_PCDDs_A_vs._C_25102007_ak.PNG]]
 +
 +
{|{{prettytable}}
 +
! Nutritional benefits and risks of PCDD/F exposure of fish consumption in Finnish children and adults  [[Media:Valikaavio_RBA_Fish_PCDDs_A_vs._C_25102007_ak_XML.ANA| Analytica model as xml-code]]
 
|-----
 
|-----
|[[Benefit-risk assessment of fish and related policy options]]
+
| [[Variable:Domestic fish consumption of a general population]] | [[Variable:Domestic fish consumption of pregnant women]] | [[Variable:Concn. of beneficial nutrients in various fish species]] | [[Variable:Omega-3-fatty acid concn.in various fish species]] | [[Variable:Exposure-response of PCDD/F intake for dental aberrations risk in children]] | [[Variable:Exposure-response of PCDD/F intake for total cancer risk in adults]] | [[Omega-3 fatty acid beneficial effects on central nervous system development in chidren]] | [[Variable:Omega-3 fatty acid protection against cancer]]
 
|}
 
|}
 +
  
 
===Indexes===
 
===Indexes===
  
*[[Variable:Age categorizations]]
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{| {{prettytable}}
*[[Variable:Fish species]]
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!Fish species
 +
|-----
 +
|
 +
*Baltic herring (Clupea harengus membras)
 +
*Herring (Clupea harengus)
 +
*Vendace (Coregonus albula)
 +
*Whitefish (Coregonus lavaretus)
 +
*Pike (Esox lucius)
 +
*Rainbow trout (Onchorhynchus mykiss)
 +
*Shrimp (Pandalus sp.)
 +
*Perch (Perca fluviatilis)
 +
*Saithe (Pollachius virens)
 +
*Atlantic salmon (Salmo salar)
 +
*Pike-perch (Sander lucioperca)
 +
*Tuna (Thunnus thynnus)
 +
|}
 +
 
 +
{| {{prettytable}}
 +
!Nutrients
 +
|-----
 +
|
 +
*Omega-3 fatty acids
 +
*Selenium
 +
*Iodine
 +
 
 +
 
 +
*Vitamin D
 +
*Vitamin E
 +
*Group B vitamins
 +
|}
 +
 
 +
 
 +
Age categorizations were chosen in order to describe health effects of fish consumption in infants (0-2 years, this class includes prenatal period as well), adolescent (2-18 years) and adults (18-55 years).
 +
 
 +
{| {{prettytable}}
 +
!Age categories (years)
 +
|-----
 +
|
 +
*0 - 2
 +
*2 - 18
 +
*18 - 55
 +
*55 -
 +
|}
  
 
===Analyses ===
 
===Analyses ===

Revision as of 21:26, 8 February 2008

Scope

Net health effects of fish consumption D↷

Purpose

Net health effects of fish consumption due to intake of beneficial nutrients and constituents and on the other hand, exposure to environmental contaminants taken up by fish. This assessment also evaluates the effects of methyl mercury and omega-3 fatty acids on development of IQ in children.


Boundaries

  • Environmental contaminants relevant from the human health point of view and thus included in the assessment are:
    • polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F)
    • polychlorinated biphenyls (PCB)
    • mercury as methyl mercury (MetHg)
  • Nutritional constituents relevant from the human health point of view include a wide variety of effects and can be viewed from Benefit-risk assessment of fish and related policy options under title "Health consequences attributable to fish consumption". However, readily usable beneficial constituents with quantitative dose-response information available included in the assessment are:
    • omega-3 polyunsaturated fatty acids (PUFA)
    • iodine (I)
    • selenium (Se)
  • European sub-populations included in the assessment:
    • Finland
    • Ireland
    • Spain
    • Denmark
  • Current situation (BAU)

Scenarios

BAU-type assessment (business-as-usual assessment), i.e. a burden-of-disease assessment with only one decision scenario. D↷

Intended users

Experts, researchers and decision makers in the field of environmental health, anyone interested and concerned with beneficial and hazardous constituents in fish species in the markets.

Participants

Participation basically completely open. Some parts containing original data will be protected.

  • Everyone interested
  • Beneris researchers (full access to the protected parts)

Definition

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Decision variables

  • None at the moment

D↷

Indicators

Indicator variables include as stated in the submodels:


Other variables

Subassessments (submodels) Variables
Variable:Assessment:Exposure risks of Hg, dioxins and PCBs and nutritional benefits of fish consumption by means of Bayesian belief networks Variable:Socio-economic status | Variable:Smoking status | Variable:Fish oil intake | Variable:Selenium intake from fish | Variable:MeHg intake from fish | Variable:Iodine intake from fish | Variable:Intake of PCBs from fish | Variable:Intake of PCDD/Fs from fish | Variable:Intelligence quotience change in children | Variable:Risk for dental aberrations in children | Variable:Cancer risk in adults | Variable:Myocardial infarction risk in adults | Variable:Exposure-response of fish oil intake for IQ change in children | Variable:Exposure-response of fish oil intake for MI risk in adults | Variable:Exposure-response of Se intake for IQ change in children | Variable:Exposure-response of Se intake for MI risk in adults | Variable:Exposure-response of MeHg intake for IQ change in children | Variable:Exposure-response of MeHg intake for MI risk in adults | Variable:Exposure-response of iodine intake for IQ change in children | Variable:Exposure-response of PCB intake for dental aberrations risk in children | Variable:Exposure-response of PCB intake for cancer risk in adults |

Variable:Exposure-response of PCDD/F intake for dental aberrations risk in children | Variable:Exposure-response of PCDD/F intake for cancer risk in adults | Variable:Exposure-response of MeHg and Se interaction for IQ change in children | Variable:Exposure-response of MeHg and Se interaction for MI risk in adults |

Beneris:Risk assessment of MeHg and n-3 fatty acids in fish Note! Assessment description and variables locate currently in Beneris-wiki accessible only for the Beneris contractors
Variable:Assessment:Nutritional benefits and risks of PCDD/F exposure of fish consumption in Finnish children and adults Variable:Domestic fish consumption of a general population | Variable:Domestic fish consumption of pregnant women | Variable:Concn. of beneficial nutrients in various fish species | Variable:Omega-3-fatty acid concn.in various fish species | Variable:Exposure-response of PCDD/F intake for dental aberrations risk in children | Variable:Exposure-response of PCDD/F intake for total cancer risk in adults | Omega-3 fatty acid beneficial effects on central nervous system development in chidren | Variable:Omega-3 fatty acid protection against cancer


Error creating thumbnail: Unable to save thumbnail to destination
Nutritional benefits and risks of PCDD/F exposure of fish consumption in Finnish children and adults Analytica model as xml-code
Variable:Domestic fish consumption of a general population | Variable:Domestic fish consumption of pregnant women | Variable:Concn. of beneficial nutrients in various fish species | Variable:Omega-3-fatty acid concn.in various fish species | Variable:Exposure-response of PCDD/F intake for dental aberrations risk in children | Variable:Exposure-response of PCDD/F intake for total cancer risk in adults | Omega-3 fatty acid beneficial effects on central nervous system development in chidren | Variable:Omega-3 fatty acid protection against cancer


Indexes

Fish species
  • Baltic herring (Clupea harengus membras)
  • Herring (Clupea harengus)
  • Vendace (Coregonus albula)
  • Whitefish (Coregonus lavaretus)
  • Pike (Esox lucius)
  • Rainbow trout (Onchorhynchus mykiss)
  • Shrimp (Pandalus sp.)
  • Perch (Perca fluviatilis)
  • Saithe (Pollachius virens)
  • Atlantic salmon (Salmo salar)
  • Pike-perch (Sander lucioperca)
  • Tuna (Thunnus thynnus)
Nutrients
  • Omega-3 fatty acids
  • Selenium
  • Iodine


  • Vitamin D
  • Vitamin E
  • Group B vitamins


Age categorizations were chosen in order to describe health effects of fish consumption in infants (0-2 years, this class includes prenatal period as well), adolescent (2-18 years) and adults (18-55 years).

Age categories (years)
  • 0 - 2
  • 2 - 18
  • 18 - 55
  • 55 -

Analyses

Result

Results

Conclusions