Difference between revisions of "ERF for Frambozadrine in rats"

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== Result ==
 
== Result ==
 +
 +
It is not clear which of the plausible methods for estimating the result is the best. The discussion is ongoing. {{disclink|Which method is the best for dose-response estimation?}}
 +
 +
===Non-parametric Bayesian estimation===
 +
 +
Males and Females combined
 +
 +
{| {{prettytable}}
 +
!Dose levels
 +
!MLE
 +
!Prior
 +
!Posterior mean
 +
!Variance
 +
|----
 +
|0
 +
|0.053
 +
|0.125
 +
|0.0571
 +
|0.0634
 +
|----
 +
|1.2
 +
|0.133
 +
|0.25
 +
|0.1052
 +
|0.0348
 +
|----
 +
|1.8
 +
|0.102
 +
|0.375
 +
|0.13
 +
|0.0241
 +
|----
 +
|15
 +
|0.091
 +
|0.5
 +
|0.154
 +
|0.021
 +
|----
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|21
 +
|0.064
 +
|0.625
 +
|0.1799
 +
|0.0551
 +
|----
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|82
 +
|0.511
 +
|0.75
 +
|0.4969
 +
|0.2762
 +
|----
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|109
 +
|0.687
 +
|0.875
 +
|0.687
 +
|0.2778
 +
|----
 +
|}

Revision as of 11:15, 24 October 2007

Scope
Frambozadrine dose-response function in rats describes the long-term health impact(s) caused by frambozadrine as a function of dose in rats. This dose-response function applies only to continuous long-term exposures of frambozadrine (like in chronic studies).

Definition

Causality

Upstream variables not defined.

Data

Toxicological data about frambozadrine in rats.

Dose(mg/kg-day) Total no rats Hyperkeratosis
Male
0 47 2
1.2 45 6
15 44 4
82 47 24
Female
0 48 3
1.8 49 5
21 47 3
109 48 33

Plausible dose-response functions

Formula

Methods for estimating dose-responses

+ Show code

Unit

probability of impact

Result

It is not clear which of the plausible methods for estimating the result is the best. The discussion is ongoing. D↷

Non-parametric Bayesian estimation

Males and Females combined

Dose levels MLE Prior Posterior mean Variance
0 0.053 0.125 0.0571 0.0634
1.2 0.133 0.25 0.1052 0.0348
1.8 0.102 0.375 0.13 0.0241
15 0.091 0.5 0.154 0.021
21 0.064 0.625 0.1799 0.0551
82 0.511 0.75 0.4969 0.2762
109 0.687 0.875 0.687 0.2778
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