Difference between revisions of "ERF of omega-3 fatty acids"
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What is the exposure-response function '''([[ERF]]) of omega-3 fatty acids'''? | What is the exposure-response function '''([[ERF]]) of omega-3 fatty acids'''? | ||
| − | == | + | == Answer == |
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| + | {{resultlink}} | ||
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| + | [[image:ERF of omega-3 fatty acids on intelligence quotient.png]] | ||
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| + | == Rationale == | ||
Exposure-response of fish oil intake for MI risk in adults is indexed by variable age. It applies to the last two age categories. | Exposure-response of fish oil intake for MI risk in adults is indexed by variable age. It applies to the last two age categories. | ||
=== Data === | === Data === | ||
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| + | <t2b index="Exposure agent,Trait,Response metric,Exposure route,Exposure metric,Exposure unit,ERF parameter,Observation" locations="Threshold,ERF" desc="Description" unit="-"> | ||
| + | DHA|Child´s IQ|Change in IQ points|Placenta|Maternal intake|mg/kg bw/day|ERS|0|0.07(±0.01)|Cohen et al. 2005; Gradowska 2013 | ||
| + | Omega3|CHD|Δlog(CHD mortality rate)|Ingestion|Intake from fish|mg/day EPA+DHA|ERS|0|-0.002 (±3.97E-4)|Mozaffarian and Rimm 2006; Gradowska 2013 | ||
| + | Fish|Subclinical brain infarct (one or more)|Prevalence|Ingestion|Intake of tuna/other fish|≥3 times/week vs. <1/month|RR|0|0.74(0.54-1.01)|Virtanen et al. 2008 | ||
| + | Fish|Any prevalent subclinical brain infarct|Prevalence|Ingestion|Intake of tuna/other fish|Each one serving per week|Decrease in RR %|0|7(0.6-12)|Virtanen et al. 2008 | ||
| + | Fish|Subclinical brain infarct (one or more)|Incidence|Ingestion|Intake of tuna/other fish|≥3 times/week vs. <1/month|RR|0|0.56(0.30-1.07)|Virtanen et al. 2008 | ||
| + | Fish|Any incident subclinical brain infarct|Incidence|Ingestion|Intake of tuna/other fish|Each one serving per week|Decrease in RR %|0|11(0.7-22)|Virtanen et al. 2008 | ||
| + | Fish|Status of cerebral white matter|Grade score|Ingestion|Intake of tuna/other fish|Each one serving per week|Increase in grade score %|0|3.8|Virtanen et al. 2008 | ||
| + | TEQ|Developmental dental defects incl. agenesis|Yes/No according to "Developmental Defects of Enamel Index" |Ingestion etc. (as it was in Seveso)|log(TCDD serum concentration+1)|ng/kg in fat|ERS|0|0.26 (±0.12)|Alaluusua et al. 2004; PL Gradowska PhD thesis 2013 | ||
| + | TEQ|Cancer|Lifetime probability of developing cancer|Ingestion|Intake|(mg/kg bw/d)^-1|Oral CSF|0|156000|US EPA | ||
| + | MeHg|Childhood intelligence|IQ change|Placenta|Maternal MeHg concentration in hair|ug /g|ERS|0|-1.5;-0.7;0| | ||
| + | </t2b> | ||
The study by Cohen et al. 2005 <ref> Cohen, J.T., PhD, Bellinger, D.C, PhD, W.E., MD, Bennett A., and Shaywitz B.A. 2005b. A Quantitative Analysis of Prenatal Intake of n-3 Polyunsaturated Fatty Acids and Cognitive Development. American Journal of Preventive Medicine 2005;29(4):366–374).</ref> estimates that increasing maternal docosahexaenoic acid (DHA) intake by 100 mg/day increases child's IQ by 0.13 points {{disclink|Other references}}. This value represents central estimate while the upper and lower bound for this ERF is 0.08 and 0.18. Triangular distribution is used. | The study by Cohen et al. 2005 <ref> Cohen, J.T., PhD, Bellinger, D.C, PhD, W.E., MD, Bennett A., and Shaywitz B.A. 2005b. A Quantitative Analysis of Prenatal Intake of n-3 Polyunsaturated Fatty Acids and Cognitive Development. American Journal of Preventive Medicine 2005;29(4):366–374).</ref> estimates that increasing maternal docosahexaenoic acid (DHA) intake by 100 mg/day increases child's IQ by 0.13 points {{disclink|Other references}}. This value represents central estimate while the upper and lower bound for this ERF is 0.08 and 0.18. Triangular distribution is used. | ||
| − | === | + | Study by Cohen et al[1] finds that prenatal MeHg exposure sufficient to increase the concentration of mercury in maternal hair at parturition by 1 µg/g decreases IQ by 0.7 points. The paper identifies important sources of uncertainty influencing this estimate, concluding that the plausible range of values for this loss is 0 to 1.5 IQ points. |
| + | A triangular distribution with parameters: min = 0, mode = 0.7 and max = 1.5 was created. Distribution by author judgement. See [[ERF of methyl mercury]]. | ||
| − | + | ; Data also from (some pages should be merged) | |
| + | * [[ERF of omega-3 fatty acids on CVD risk in adults]] | ||
| + | * [[ERF of fish intake on neurological disorders in adults]] | ||
| + | * [[ERF of TCDD]] | ||
| + | * [[ERF of dioxin]] | ||
| + | * [[ERF of methyl mercury]] | ||
===Unit=== | ===Unit=== | ||
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IQ points/(100mg omega-3/d) | IQ points/(100mg omega-3/d) | ||
| − | === | + | === Calculations === |
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==References== | ==References== | ||
<references/> | <references/> | ||
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Question
What is the exposure-response function (ERF) of omega-3 fatty acids?
Answer
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Rationale
Exposure-response of fish oil intake for MI risk in adults is indexed by variable age. It applies to the last two age categories.
Data
| Obs | Exposure agent | Trait | Response metric | Exposure route | Exposure metric | Exposure unit | ERF parameter | Threshold | ERF | Description |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | DHA | Child´s IQ | Change in IQ points | Placenta | Maternal intake | mg/kg bw/day | ERS | 0 | 0.07(±0.01) | Cohen et al. 2005; Gradowska 2013 |
| 2 | Omega3 | CHD | Δlog(CHD mortality rate) | Ingestion | Intake from fish | mg/day EPA+DHA | ERS | 0 | -0.002 (±3.97E-4) | Mozaffarian and Rimm 2006; Gradowska 2013 |
| 3 | Fish | Subclinical brain infarct (one or more) | Prevalence | Ingestion | Intake of tuna/other fish | ≥3 times/week vs. <1/month | RR | 0 | 0.74(0.54-1.01) | Virtanen et al. 2008 |
| 4 | Fish | Any prevalent subclinical brain infarct | Prevalence | Ingestion | Intake of tuna/other fish | Each one serving per week | Decrease in RR % | 0 | 7(0.6-12) | Virtanen et al. 2008 |
| 5 | Fish | Subclinical brain infarct (one or more) | Incidence | Ingestion | Intake of tuna/other fish | ≥3 times/week vs. <1/month | RR | 0 | 0.56(0.30-1.07) | Virtanen et al. 2008 |
| 6 | Fish | Any incident subclinical brain infarct | Incidence | Ingestion | Intake of tuna/other fish | Each one serving per week | Decrease in RR % | 0 | 11(0.7-22) | Virtanen et al. 2008 |
| 7 | Fish | Status of cerebral white matter | Grade score | Ingestion | Intake of tuna/other fish | Each one serving per week | Increase in grade score % | 0 | 3.8 | Virtanen et al. 2008 |
| 8 | TEQ | Developmental dental defects incl. agenesis | Yes/No according to "Developmental Defects of Enamel Index" | Ingestion etc. (as it was in Seveso) | log(TCDD serum concentration+1) | ng/kg in fat | ERS | 0 | 0.26 (±0.12) | Alaluusua et al. 2004; PL Gradowska PhD thesis 2013 |
| 9 | TEQ | Cancer | Lifetime probability of developing cancer | Ingestion | Intake | (mg/kg bw/d)^-1 | Oral CSF | 0 | 156000 | US EPA |
| 10 | MeHg | Childhood intelligence | IQ change | Placenta | Maternal MeHg concentration in hair | ug /g | ERS | 0 | -1.5;-0.7;0 |
The study by Cohen et al. 2005 [1] estimates that increasing maternal docosahexaenoic acid (DHA) intake by 100 mg/day increases child's IQ by 0.13 points D↷. This value represents central estimate while the upper and lower bound for this ERF is 0.08 and 0.18. Triangular distribution is used.
Study by Cohen et al[1] finds that prenatal MeHg exposure sufficient to increase the concentration of mercury in maternal hair at parturition by 1 µg/g decreases IQ by 0.7 points. The paper identifies important sources of uncertainty influencing this estimate, concluding that the plausible range of values for this loss is 0 to 1.5 IQ points. A triangular distribution with parameters: min = 0, mode = 0.7 and max = 1.5 was created. Distribution by author judgement. See ERF of methyl mercury.
- Data also from (some pages should be merged)
- ERF of omega-3 fatty acids on CVD risk in adults
- ERF of fish intake on neurological disorders in adults
- ERF of TCDD
- ERF of dioxin
- ERF of methyl mercury
Unit
IQ points/(100mg omega-3/d)
Calculations
References
- ↑ Cohen, J.T., PhD, Bellinger, D.C, PhD, W.E., MD, Bennett A., and Shaywitz B.A. 2005b. A Quantitative Analysis of Prenatal Intake of n-3 Polyunsaturated Fatty Acids and Cognitive Development. American Journal of Preventive Medicine 2005;29(4):366–374).
