Difference between revisions of "ERF of omega-3 fatty acids"
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+ | = ERF of fish intake on neurological disorders in adults = | ||
+ | |||
+ | {{variable}} | ||
+ | [[Category:Health effects]] | ||
+ | [[Category:Fish]] | ||
+ | == Scope == | ||
+ | |||
+ | What is the exposure-response function ([[ERF]]) of omega-3-rich fish intake on neurological disorders in adults? Especially the focus is on brain infarction. | ||
+ | |||
+ | == Definition == | ||
+ | |||
+ | === Data === | ||
+ | |||
+ | In a recent study, 3660 over 65-year-old individuals were monitored for five years, and the change in small brain infarctions was observed by magnetic resonance imageing. The infaction risk was 25 % lower in those who ate at least three portions of omega-3-rich fish meals per week, and 13 % lower in those who ate one meal per week.<ref>Fish consumption and risk of subclinical brain abnormalities on MRI in older adults | ||
+ | Jyrki K. Virtanen, David S. Siscovick, Will T. Longstreth, Lewis H. Kuller, Dariush Mozaffarian | ||
+ | Neurology 2008;71:439–446.</ref> | ||
+ | |||
+ | === Causality === | ||
+ | |||
+ | None identified. | ||
+ | |||
+ | === Unit === | ||
+ | |||
+ | % change / # fish portions per week | ||
+ | |||
+ | === Formula === | ||
+ | |||
+ | == Result == | ||
+ | |||
+ | <t2b index="Disease,Response metric,Exposure route,Exposure metric,Exposure unit,Threshold,ERF parameter,Observation" locations="ERF,Description" unit="-"> | ||
+ | Subclinical brain infarct (one or more)|Prevalence|Ingestion|Intake of tuna/other fish|≥3 times/week vs. <1/month||RR|0.74(0.54-1.01)|Virtanen et al. 2008 | ||
+ | Any prevalent subclinical brain infarct|Prevalence|Ingestion|Intake of tuna/other fish|Each one serving per week||Decrease in RR %|7(0.6-12)|Virtanen et al. 2008 | ||
+ | Subclinical brain infarct (one or more)|Incidence|Ingestion|Intake of tuna/other fish|≥3 times/week vs. <1/month||RR|0.56(0.30-1.07)|Virtanen et al. 2008 | ||
+ | Any incident subclinical brain infarct|Incidence|Ingestion|Intake of tuna/other fish|Each one serving per week||Decrease in RR %|11(0.7-22)|Virtanen et al. 2008 | ||
+ | Status of cerebral white matter|Grade score|Ingestion|Intake of tuna/other fish|Each one serving per week||Increase in grade score %|3.8|Virtanen et al. 2008 | ||
+ | </t2b> | ||
+ | |||
+ | ==See also== | ||
+ | |||
+ | * [http://www.kampus.uku.fi/tiedotteet/tiedote.shtml?v=2008&tied=12179163101552 A press release from the University of Kuopio (in Finnish)] | ||
+ | |||
+ | ==References== | ||
+ | |||
+ | <references/> | ||
+ | |||
+ | = ERF of omega-3 fatty acids on CVD risk in adults = | ||
+ | |||
+ | [[Category:Fish]] | ||
+ | {{variable}} | ||
+ | |||
+ | <br> | ||
+ | |||
+ | == Scope == | ||
+ | |||
+ | '''ERF of omega-3 fatty acids on CVD risk in adults '''describes quantitative relationship between exposure to omega-3 fatty acids and risk of cardiovascular disease (CVD) in adults. <br> | ||
+ | |||
+ | == Definition == | ||
+ | |||
+ | '''ERF of omega-3 fatty acids on CVD risk in adults''' is represented as a random variable. It is indexed by variable age. It applies to the last two age categories of the Beneris population, i.e. adults aged 18-55yr and 55yr+ (gender combined). | ||
+ | |||
+ | === Causality === | ||
+ | List of parents: | ||
+ | *[[Body weight in Finland]] | ||
+ | |||
+ | === Data === | ||
+ | |||
+ | Fernandez-Jarne et al. <ref>Fernandez-Jarne E, Garrido FA, Gutierrez AA, Arrillaga CDF, Martinez-Gonzales MA. Dietary intake of n-3 fatty acids and the risk of acute myocardial infarction: a case-control study. (In Spanish) 2002;118:121–5.</ref> examined the relationship between intake of fish and n-3 PUFA and the risk of first acute myocardial infarction (AMI) in a low risk population from Navarre (Spain). They found that the n-3 PUFA intake has a protective effect on AMI. The adjusted odds ratio (OR) for the second and third tertile of n-3 PUFA intake were 0.44 (95% Cl, 0.21-0.91) and 0.47 (95% Cl, 0.22-1.00), respectively. The trend test was not statistically significant. {{Disclink| Time unit for ERF of n-3 PUFA}} | ||
+ | |||
+ | Mozaffarian and Rimm <ref name="Rimm"> Mozaffarian D., Rimm E.B., Fish intake, contaminants, and human health. Evaluating the risks and the benefits. (Reprinted) JAMA, 2006. Vol 296, No. 15 </ref> estimated that at intakes between 0 and 250 mg/d, the relative risk of coronary heart disease (CHD) death is lower by 14.6% (95% CI: 8% to 21%) per each 100 mg/d of EPA and DHA intake and that at higher intakes ( > 250 mg/d) the risk reduction is 0.0% (95% CI: -0.9% to 0.8%) per each 100 mg/d. | ||
+ | |||
+ | The ERF of omega-3 fatty acids (DHA+EPA) intake from fish (in unit of mg/kg bw-day) on the CHD mortality is estimated based on information provided in <ref name="Rimm" />. First, the central estimate and the 95% CI for the change (in this case decrease) in natural logarithm of relative risk (RR) of CHD mortality per unit change in omega-3 fatty acids intake (in unit of mg/day) in both intake intervals were derived. In general, the relationship between the percent change in RR (%RR) associated with c-unit increase in omega-3 fatty acids intake and the incremental change in lnRR (beta) per unit change in omega-3 fatty acids intake is beta = (1/c)*ln((%RR/100)+1). Normal distribution was chosen to describe the uncertainty in the parameter of the log-linear model for RR in each intake interval. For intake of EPA+DHA between 0 and 250 mg/day the mean and the standard | ||
+ | deviation of parameter distribution are -0.0016 and 0.0004, for higher intakes 0 and 0.0005. Then, the distribution of ERF of omega-3 fatty acids intake from fish in units of mg/kg bw-day was obtained by multiplying ERFs of omega-3 fatty acids intake measured in mg/day by the body weight of adult. | ||
+ | |||
+ | === Unit === | ||
+ | |||
+ | lnRR/ 1 (mg/kg bw-day) change in EPA+DHA intake from fish | ||
+ | |||
+ | === Formula === | ||
+ | |||
+ | For intakes of EPA+DHA from fish between 0 and 250 mg/day: N(-0.0016,0.0004)*BW<br> | ||
+ | For intakes of EPA+DHA from fish higher than 250 mg/day: N(0,0.0005)*BW | ||
+ | |||
+ | == Result == | ||
+ | |||
+ | <t2b name="ERF of PUFA on CVD" index="Exposure agent,Disease,Response metric,Exposure route,Exposure metric,Exposure unit,Threshold,ERF parameter" obs="ERF" desc="Description" unit="-"> | ||
+ | PUFA|CHD|Δlog(CHD mortality rate)|Ingestion|Intake from fish|mg/day EPA+DHA|0|ERS|-0.002 (±3.97E-4)|Mozaffarian and Rimm 2006; Gradowska 2013 | ||
+ | </t2b> | ||
+ | |||
+ | == References == | ||
+ | |||
+ | <br> <references /> |
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Contents
Question
What is the exposure-response function (ERF) of omega-3 fatty acids?
Answer
Rationale
Exposure-response of fish oil intake for MI risk in adults is indexed by variable age. It applies to the last two age categories.
Data
ERF
Obs | Exposure agent | Trait | Response metric | Exposure route | Exposure metric | Exposure unit | ERF parameter | Threshold | ERF | Description |
---|---|---|---|---|---|---|---|---|---|---|
1 | DHA | Child´s IQ | Change in IQ points | Placenta | Maternal intake | mg/kg bw/day | ERS | 0 | 0.07 +- 0.01 | Cohen et al. 2005; Gradowska 2013; Standard deviation |
2 | Omega3 | CHD | Δlog(CHD mortality rate) | Ingestion | Intake from fish | mg/day EPA+DHA | RR | 0 | 0.9802 +- 0.000389 | Mozaffarian and Rimm 2006; Gradowska 2013 SD = exp(-0.02)-exp(-0.02+3.97E-4) |
3 | Fish | Subclinical brain infarct (one or more) | Prevalence | Ingestion | Intake of tuna/other fish | ≥3 times/week vs. <1/month | RR | 0 | 0.74 (0.54 - 1.01) | Virtanen et al. 2008; 95% CI |
4 | Fish | Any prevalent subclinical brain infarct | Prevalence | Ingestion | Intake of tuna/other fish | Each one serving per week | RR | 0 | 0.93 (0.88 - 0.994) | Virtanen et al. 2008; 95% CI |
5 | Fish | Subclinical brain infarct (one or more) | Incidence | Ingestion | Intake of tuna/other fish | ≥3 times/week vs. <1/month | RR | 0 | 0.56 (0.30 - 1.07) | Virtanen et al. 2008; 95% CI |
6 | Fish | Any incident subclinical brain infarct | Incidence | Ingestion | Intake of tuna/other fish | Each one serving per week | RR | 0 | 0.89 (0.78 - 0.993) | Virtanen et al. 2008; 95% CI |
7 | Fish | Status of cerebral white matter | Grade score | Ingestion | Intake of tuna/other fish | Each one serving per week | 1 /grade score | 0 | 0.038 | Virtanen et al. 2008; 95% CI |
8 | TEQ | Developmental dental defects incl. agenesis | Yes/No according to "Developmental Defects of Enamel Index" | Ingestion etc. (as it was in Seveso) | log(TCDD serum concentration+1) | ng/kg in fat | ERS | 0 | 0.26 +- 0.12 | Alaluusua et al. 2004; PL Gradowska PhD thesis 2013; ERF:n laatu on epäselvä |
9 | TEQ | Cancer | Lifetime probability of developing cancer | Ingestion | Intake | kg bw d /mg | Oral CSF | 0 | 156000 | US EPA: onko ajantasainen, ei löydy EPAn sivuilta(?) |
10 | MeHg | Childhood intelligence | IQ change | Placenta | Maternal MeHg concentration in hair | ug /g | ERS | 0 | -0.7 (-1.5 - 0) |
ERF publications
Exposure agent | Trait | Response metric | Exposure route | Exposure metric | Exposure unit | ERF parameter | Threshold | ERF | Description |
---|---|---|---|---|---|---|---|---|---|
DHA | Child´s IQ | Change in IQ points | Placenta | Maternal intake | mg/kg bw/day | ERS | 0 | 0.07(±0.01) | Cohen et al. 2005; Gradowska 2013 |
Omega3 | CHD | Δlog(CHD mortality rate) | Ingestion | Intake from fish | mg/day EPA+DHA | ERS | 0 | -0.002 (±3.97E-4) | Mozaffarian and Rimm 2006; Gradowska 2013 |
Fish | Subclinical brain infarct (one or more) | Prevalence | Ingestion | Intake of tuna/other fish | =3 times/week vs. <1/month | RR | 0 | 0.74(0.54-1.01) | Virtanen et al. 2008 |
Fish | Any prevalent subclinical brain infarct | Prevalence | Ingestion | Intake of tuna/other fish | Each one serving per week | Decrease in RR % | 0 | 7(0.6-12) | Virtanen et al. 2008 |
Fish | Subclinical brain infarct (one or more) | Incidence | Ingestion | Intake of tuna/other fish | =3 times/week vs. <1/month | RR | 0 | 0.56(0.30-1.07) | Virtanen et al. 2008 |
Fish | Any incident subclinical brain infarct | Incidence | Ingestion | Intake of tuna/other fish | Each one serving per week | Decrease in RR % | 0 | 11(0.7-22) | Virtanen et al. 2008 |
Fish | Status of cerebral white matter | Grade score | Ingestion | Intake of tuna/other fish | Each one serving per week | Increase in grade score % | 0 | 3.8 | Virtanen et al. 2008 |
TEQ | Developmental dental defects incl. agenesis | Yes/No according to "Developmental Defects of Enamel Index" | Ingestion etc. (as it was in Seveso) | log(TCDD serum concentration+1) | ng/kg in fat | ERS | 0 | 0.26 (±0.12) | Alaluusua et al. 2004; PL Gradowska PhD thesis 2013 |
TEQ | Cancer | Lifetime probability of developing cancer | Ingestion | Intake | (mg/kg bw/d)^-1 | Oral CSF | 0 | 156000 | US EPA |
MeHg | Childhood intelligence | IQ change | Placenta | Maternal MeHg concentration in hair | ug /g | ERS | 0 | -1.5;-0.7;0 |
The study by Cohen et al. 2005 [1] estimates that increasing maternal docosahexaenoic acid (DHA) intake by 100 mg/day increases child's IQ by 0.13 points D↷. This value represents central estimate while the upper and lower bound for this ERF is 0.08 and 0.18. Triangular distribution is used.
Study by Cohen et al[1] finds that prenatal MeHg exposure sufficient to increase the concentration of mercury in maternal hair at parturition by 1 µg/g decreases IQ by 0.7 points. The paper identifies important sources of uncertainty influencing this estimate, concluding that the plausible range of values for this loss is 0 to 1.5 IQ points. A triangular distribution with parameters: min = 0, mode = 0.7 and max = 1.5 was created. Distribution by author judgement. See ERF of methyl mercury.
- Data also from (some pages should be merged)
- ERF of omega-3 fatty acids on CVD risk in adults
- ERF of fish intake on neurological disorders in adults
- ERF of TCDD
- ERF of dioxin
- ERF of methyl mercury
Incidences
Obs | Trait | Response metric | Age | Incidence | Description |
---|---|---|---|---|---|
1 | CHD | Incidence | Adult | 0.0025 | 10000 CHD deaths per 4000000 py in Finland |
2 | Subclinical brain infarct (one or more) | Incidence | Adult | 0.0025 | guesswork |
Unit
IQ points/(100mg omega-3/d)
Calculations
References
- ↑ Cohen, J.T., PhD, Bellinger, D.C, PhD, W.E., MD, Bennett A., and Shaywitz B.A. 2005b. A Quantitative Analysis of Prenatal Intake of n-3 Polyunsaturated Fatty Acids and Cognitive Development. American Journal of Preventive Medicine 2005;29(4):366–374).
ERF of fish intake on neurological disorders in adults
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Scope
What is the exposure-response function (ERF) of omega-3-rich fish intake on neurological disorders in adults? Especially the focus is on brain infarction.
Definition
Data
In a recent study, 3660 over 65-year-old individuals were monitored for five years, and the change in small brain infarctions was observed by magnetic resonance imageing. The infaction risk was 25 % lower in those who ate at least three portions of omega-3-rich fish meals per week, and 13 % lower in those who ate one meal per week.[1]
Causality
None identified.
Unit
% change / # fish portions per week
Formula
Result
Obs | Disease | Response metric | Exposure route | Exposure metric | Exposure unit | Threshold | ERF parameter | ERF | Description |
---|---|---|---|---|---|---|---|---|---|
1 | Subclinical brain infarct (one or more) | Prevalence | Ingestion | Intake of tuna/other fish | ≥3 times/week vs. <1/month | RR | 0.74(0.54-1.01) | Virtanen et al. 2008 | |
2 | Any prevalent subclinical brain infarct | Prevalence | Ingestion | Intake of tuna/other fish | Each one serving per week | Decrease in RR % | 7(0.6-12) | Virtanen et al. 2008 | |
3 | Subclinical brain infarct (one or more) | Incidence | Ingestion | Intake of tuna/other fish | ≥3 times/week vs. <1/month | RR | 0.56(0.30-1.07) | Virtanen et al. 2008 | |
4 | Any incident subclinical brain infarct | Incidence | Ingestion | Intake of tuna/other fish | Each one serving per week | Decrease in RR % | 11(0.7-22) | Virtanen et al. 2008 | |
5 | Status of cerebral white matter | Grade score | Ingestion | Intake of tuna/other fish | Each one serving per week | Increase in grade score % | 3.8 | Virtanen et al. 2008 |
See also
References
- ↑ Fish consumption and risk of subclinical brain abnormalities on MRI in older adults Jyrki K. Virtanen, David S. Siscovick, Will T. Longstreth, Lewis H. Kuller, Dariush Mozaffarian Neurology 2008;71:439–446.
ERF of omega-3 fatty acids on CVD risk in adults
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Scope
ERF of omega-3 fatty acids on CVD risk in adults describes quantitative relationship between exposure to omega-3 fatty acids and risk of cardiovascular disease (CVD) in adults.
Definition
ERF of omega-3 fatty acids on CVD risk in adults is represented as a random variable. It is indexed by variable age. It applies to the last two age categories of the Beneris population, i.e. adults aged 18-55yr and 55yr+ (gender combined).
Causality
List of parents:
Data
Fernandez-Jarne et al. [1] examined the relationship between intake of fish and n-3 PUFA and the risk of first acute myocardial infarction (AMI) in a low risk population from Navarre (Spain). They found that the n-3 PUFA intake has a protective effect on AMI. The adjusted odds ratio (OR) for the second and third tertile of n-3 PUFA intake were 0.44 (95% Cl, 0.21-0.91) and 0.47 (95% Cl, 0.22-1.00), respectively. The trend test was not statistically significant. D↷
Mozaffarian and Rimm [2] estimated that at intakes between 0 and 250 mg/d, the relative risk of coronary heart disease (CHD) death is lower by 14.6% (95% CI: 8% to 21%) per each 100 mg/d of EPA and DHA intake and that at higher intakes ( > 250 mg/d) the risk reduction is 0.0% (95% CI: -0.9% to 0.8%) per each 100 mg/d.
The ERF of omega-3 fatty acids (DHA+EPA) intake from fish (in unit of mg/kg bw-day) on the CHD mortality is estimated based on information provided in [2]. First, the central estimate and the 95% CI for the change (in this case decrease) in natural logarithm of relative risk (RR) of CHD mortality per unit change in omega-3 fatty acids intake (in unit of mg/day) in both intake intervals were derived. In general, the relationship between the percent change in RR (%RR) associated with c-unit increase in omega-3 fatty acids intake and the incremental change in lnRR (beta) per unit change in omega-3 fatty acids intake is beta = (1/c)*ln((%RR/100)+1). Normal distribution was chosen to describe the uncertainty in the parameter of the log-linear model for RR in each intake interval. For intake of EPA+DHA between 0 and 250 mg/day the mean and the standard deviation of parameter distribution are -0.0016 and 0.0004, for higher intakes 0 and 0.0005. Then, the distribution of ERF of omega-3 fatty acids intake from fish in units of mg/kg bw-day was obtained by multiplying ERFs of omega-3 fatty acids intake measured in mg/day by the body weight of adult.
Unit
lnRR/ 1 (mg/kg bw-day) change in EPA+DHA intake from fish
Formula
For intakes of EPA+DHA from fish between 0 and 250 mg/day: N(-0.0016,0.0004)*BW
For intakes of EPA+DHA from fish higher than 250 mg/day: N(0,0.0005)*BW
Result
Obs | Exposure agent | Disease | Response metric | Exposure route | Exposure metric | Exposure unit | Threshold | ERF parameter | ERF | Description |
---|---|---|---|---|---|---|---|---|---|---|
1 | PUFA | CHD | Δlog(CHD mortality rate) | Ingestion | Intake from fish | mg/day EPA+DHA | 0 | ERS | -0.002 (±3.97E-4) | Mozaffarian and Rimm 2006; Gradowska 2013 |
References
- ↑ Fernandez-Jarne E, Garrido FA, Gutierrez AA, Arrillaga CDF, Martinez-Gonzales MA. Dietary intake of n-3 fatty acids and the risk of acute myocardial infarction: a case-control study. (In Spanish) 2002;118:121–5.
- ↑ 2.0 2.1 Mozaffarian D., Rimm E.B., Fish intake, contaminants, and human health. Evaluating the risks and the benefits. (Reprinted) JAMA, 2006. Vol 296, No. 15