IRIS

This page provides a description and a link to a "IRIS" database that provides information needed when modeling exposure levels or performing exposure assessment.

Short description

IRIS is a database of human health effects that may result from exposure to various substances found in the environment. The heart of the IRIS system is its collection of computer files covering individual chemicals. These chemical files contain descriptive and quantitative information in the following categories: a) Oral reference doses and inhalation reference concentrations (RfDs and RfCs, respectively) for chronic noncarcinogenic health effects, b) Hazard identification, oral slope factors, and oral and inhalation unit risks for carcinogenic effects. Database includes over 500 chemicals.

Long description

http://www.nlm.nih.gov/pubs/factsheets/irisfs.html

Link

http://www.epa.gov/iris/

Key words

human health effects, exposure, toxicology, carcinogenity, hazards

Data scrapping

IRIS database is accessible from this link: http://cfpub.epa.gov/ncea/iris/compare.cfm. The critical data can be obtained at once if all substances and all types of data are selected. A result is an html file with several tables from which the data can be scrapped and transformed into a better format. The January 4th, 2012, version was downloaded from IRIS and saved on this page (see the file below). Who could do this?

Reference system in IRIS database. The number (e.g. 0442) refers to the IRIS chemical identifier.

QuickView
http://cfpub.epa.gov/ncea/iris/quickview.cfm?substance_nmbr=0442#reforal  Oral RfDs
http://cfpub.epa.gov/ncea/iris/quickview.cfm?substance_nmbr=0442#refinhal Inhalation RfCs
http://cfpub.epa.gov/ncea/iris/quickview.cfm?substance_nmbr=0442#woe      Weight-of-Evidence Characterizations
http://cfpub.epa.gov/ncea/iris/quickview.cfm?substance_nmbr=0442#quaoral  Oral Slope Factors/Drinking Water Unit Risks
http://cfpub.epa.gov/ncea/iris/quickview.cfm?substance_nmbr=0442#quainhal Inhalation Unit Risks

IRIS Summary 
http://www.epa.gov/iris/subst/0442.htm#reforal
http://www.epa.gov/iris/subst/0442.htm#refinhal
http://www.epa.gov/iris/subst/0442.htm#woe
http://www.epa.gov/iris/subst/0442.htm#quaoral
http://www.epa.gov/iris/subst/0442.htm#quainhal

Toxicological Review (PDF)
http://www.epa.gov/iris/toxreviews/0128tr.pdf (this does not exist for many compounds)

Oral RfDs

Oral RfDs were scrapped as an example (chemical starting with A) on Jan 4, 2012.

⇤# : Ei tätä kannata tehdä rivi kerrallaan, vaan ottaa koko viiden taulukon tiedosto (ks. Related files) muokata siitä tekstinkäsittelyohjelmalla viisi t2b-taulukkoa. Etsi-korvaa-toiminnolla voi tehdä suurimman osan muotoiluista. Kannattaa kysyä apua jos ei osaa, koska muuten työssä menee päiviä. --Jouni 10:42, 20 June 2012 (EEST)

⇤#: Huomaa, että IRIS identifier on tärkeä. Se löytyy nettilinkeistä (esim. Acenaphthenen QuickView on tämmöinen linkki: http://cfpub.epa.gov/ncea/iris/quickview.cfm?substance_nmbr=0442#reforal ja siitä näkee, että tämän aineen IRIS identifier on 0442. --Jouni 10:42, 20 June 2012 (EEST)

IRIS(mg /kg-day)

Obs	Substance	CASRN	Critical Effact(s)	Unit	Oral RfD	Type of RfD	Point of Departure(s)*	Overall Confidence	IRIS identifier
1	Acenaphthene	83-32-9	Hepatotoxicity	mg /kg-day	6 x10-2	NOAEL	175	Low	0442
2	Acenaphthylene	208-96-8	Not Assessed under the IRIS program						0443
3	Acephate	30560-19-1	Inhibition of brain ChE	mg /kg-day	4 x10-3	LEL	0.12	High	0354
4	Acetaldehyde	75-07-0	Not Assessed under the IRIS program						0290
5	Acetochlor	34256-82-1	Salivation, increased ALT and ornithine carbamyl transferase; significant increases in triglyceride and decreased blood glucose levels; histopathological changes in kidneys and testes of males	mg /kg-day	2 x10-2	NOAEL	2 mg/kg-day	High	0521
6	Acetone	67-64-1	Nephropathy	mg /kg-day	0.9	NOAEL	900	Medium	0128
7	Acetonitrile	75-05-8	Information reviewed but value not estimated. Refer to IRIS Summary.						0205
8	Acetophenone	98-86-2	General toxicity	mg /kg-day	1 x10-1	NOAEL	423	Low	0321
9	Acetyl chloride	75-36-5	Not Assessed under the IRIS program						0518
10	Acifluorfen, sodium	62476-59-9	Mortality and kidney lesions	mg /kg-day	1.3 x10-2	NOEL	1.25	Medium	0192
11	Acrolein	107-02-8	Decreased survival	mg /kg-day	5 x10-4	NOAEL	0.05	Medium/High	0364
12	Acrylamide	79-06-1	Degenerative nerve changes	mg /kg-day	0.002	HED (BMDL)	0.053	Medium/High	0286
13	Acrylic acid	79-10-7	Reduced pup weight	mg /kg-day	5 x10-1	NOAEL	53	High	0002
14	Acrylonitrile	107-13-1	Not Assessed under the IRIS program						0206
15	Adiponitrile	111-69-3	Not Assessed under the IRIS program						0515
16	Alachlor	15972-60-8	Hemosiderosis, hemolytic anemia	mg /kg-day	1 x10-2	NOAEL	1	High	0129
17	Alar	1596-84-5	No adverse effects	mg /kg-day	1.5 x10-1	NOEL	15	Low	0287
18	Aldicarb	116-06-3	Sweating as clinical sign of AChe inhibition (other effect: Clinical signs and symptoms of acetylcholinesterase inhibition including sweating, pinpoint pupils, leg weakness, and other effects Nausea, diarrhea, and other signs and symptoms)	mg /kg-day	1 x10-3	NOAEL	0.01	Medium	0003
19	Aldicarb sulfone	1646-88-4	Brain ChE inhibition in females	mg /kg-day	1 x10-3	NOAEL	0.11	Medium	0312
20	Aldrin	309-00-2	Liver toxicity	mg /kg-day	3 x10-5	LOAEL	0.025	Medium	0130
21	Ally	74223-64-6	Decreased body weight	mg /kg-day	2.5 x10-1	NOEL	25	High	0288
22	Allyl alcohol	107-18-6	Impaired renal function and increased liver and kidney weights	mg /kg-day	5 x10-3	NOEL	4.8	Low	0004
23	Allyl chloride	107-05-1	Not Assessed under the IRIS program						0387
24	Aluminum phosphide	20859-73-8	Body weight and clinical parameters	mg /kg-day	4 x10-4	NOAEL	0.043	Medium	0005
25	Amdro	67485-29-4	Increased organ weights	mg /kg-day	3 x10-4	NOEL	0.33	High	0207
26	Ametryn	834-12-8	Liver toxicity	mg /kg-day	9 x10-3	NOEL	8.6	Low	0208
27	4-Aminopyridine	504-24-5	Not Assessed under the IRIS program						0440
28	Amitraz	33089-61-1	Increased mean blood sugar concentration; slight hypothermia	mg /kg-day	2.5 x10-3	NOEL	0.25	Medium	0334
29	Ammonia	7664-41-7	Not Assessed under the IRIS program						0422
30	Ammonium acetate	631-61-8	Not Assessed under the IRIS program						0517
31	Ammonium methacrylate	16325-47-6	Not Assessed under the IRIS program						0516
32	Ammonium sulfamate	7773-06-0	Decrease in body weight	mg /kg-day	2 x10-1	NOEL	214.3	Low	0007
33	Aniline	62-53-3	Not Assessed under the IRIS program						0350
34	ortho-Anisidine	90-04-0	Not Assessed under the IRIS program						0610
35	Anthracene	120-12-7	No observed effects	mg /kg-day	3 x10-1	NOEL	1000	Low	0434
36	Antimony	7440-36-0	Longevity, blood glucose, and cholesterol	mg /kg-day	4 x10-4	LOAEL	0.35	Low	0006
37	Antimony trioxide	1309-64-4	Not Assessed under the IRIS program						0676
38	Apollo	74115-24-5	Liver effects; organ weight changes	mg /kg-day	1.3 x10-2	NOEL	1.25	High	0008
39	Aramite	140-57-8	Not Assessed under the IRIS program						0473
40	Aroclor 1016	12674-11-2	Reduced birth weights	mg /kg-day	7 x10-5	NOAEL	0.007	Medium	0462
41	Aroclor 1248	12672-29-6	Information reviewed but value not estimated. Refer to IRIS Summary.						0649
42	Aroclor 1254	11097-69-1	Ocular exudate, inflamed and prominent Meibomian glands, distorted growth of finger and toe nails; decreased antibody (IgG and IgM) response to sheep erythrocytes	mg /kg-day	2 x10-5	LOAEL	0.005	Medium	0389
43	Arsenic, inorganic	7440-38-2	Hyperpigmentation, keratosis and possible vascular complications	mg /kg-day	3 x10-4	NOAEL	0.0008	Medium	0278
44	Arsine	7784-42-1	Not Assessed under the IRIS program						0672
45	Asbestos	1332-21-4	Not Assessed under the IRIS program						0371
46	Assure	76578-14-8	Liver cell enlargement	mg /kg-day	9 x10-3	NOEL	0.9	High	0335
47	Asulam	3337-71-1	Lower ovarian weight, lower liver/body weight	mg /kg-day	5 x10-2	LEL	50	Medium	0284
48	Atrazine	1912-24-9	Decreased body weight gain (other effect: Cardiac toxicity and moderate-to-severe dilation of the right atrium)	mg /kg-day	3.5 x10-2	NOAEL	3.5	High	0209
49	Avermectin B1	65195-55-3	Increased retinal folds in weanlings, decreased viability and lactation indices, decreased pup body weight, increase of dead pups at birth	mg /kg-day	4 x10-4	NOEL	0.12	High	0381
50	Azobenzene	103-33-3	Not Assessed under the IRIS program						0351
51	Barium and Compounds	7440-39-3	Nephropathy	mg /kg-day	0.2	BMDL05	63	Medium	0010
52	Barium cyanide	542-62-1	Information reviewed but value not estimated. Refer to IRIS Summary.						0009
53	Baygon	114-26-1	Mild cholinergic symptoms and RBD ChE inhibition	mg /kg-day	4 x10-3	LEL	0.36	Medium	0210
54	Bayleton	43121-43-3	Decreased body weight gain, erythrocyte count and hemoglobin level	mg /kg-day	3 x10-2	NOEL	2.5	High	0131
55	Baythroid	68359-37-5	Decreased body weights in males, inflammatory foci in kidneys of females	mg /kg-day	2.5 x10-2	NOEL	2.5	High	0132
56	Benefin	1861-40-1	Depressed erythrocyte counts	mg /kg-day	3 x10-1	NOAEL	25	Medium	0133
57	Benomyl	17804-35-2	Decreased pup weanling weights	mg /kg-day	5 x10-2	NOEL	5 mg/kg-day	High	0011
58	Bentazon (Basagran)	25057-89-0	Blood loss into the gastrointestinal tract; coagulation defect in male and female dogs (other effect: Dose-related increase in red areas (presumed blood) in feces; coagulation defect)	mg /kg-day	3.0 x10-2	NOAEL (ADJ)	3.2	Medium	0134
59	Benz[a]anthracene	56-55-3	Not Assessed under the IRIS program						0454
60	Benzaldehyde	100-52-7	Forestomach lesions, kidney toxicity	mg /kg-day	1 x10-1	NOEL	143	Low	0332
61	Benzene	71-43-2	Decreased lymphocyte count	mg /kg-day	4.0 x10-3	BMDL	1.2	Medium	0276
62	Benzidine	92-87-5	Brain cell vacuolization; liver cell alterations in females	mg /kg-day	3 x10-3	LOAEL	2.7	Medium	0135

Inhalation RfCs

IRIS(mg /m

Obs	Substance	CASRN	Critical Effact(s)	Unit	Inhalation RfC	Type of RfC	Point of Departure(s)*	Overall Confidence	IRIS identifier
1	Acenaphthene	83-32-9	Not Assessed under the IRIS program.
2	Acenaphthylene	208-96-8	Not Assessed under the IRIS program.
3	Acephate	30560-19-1	Not Assessed under the IRIS program.
4	Acetaldehyde	75-07-0	Degeneration of olfactory epithelium	mg /m3	9x10-3	NOAEL (HEC)	8.7	Low	0290
5	Acetochlor	34256-82-1	Not Assessed under the IRIS program.
6	Acetone	67-64-1	Not Assessed under the IRIS program.
7	Acetonitrile	75-05-8	Not Assessed under the IRIS program.
8	Acetophenone	98-86-2	Mortality	mg /m3	6x10-2	NOAEL (HEC)	60	Medium	0205
9	Acetyl chloride	75-36-5	Not Assessed under the IRIS program.
10	Acifluorfen, sodium	62476-59-9	Not Assessed under the IRIS program.
11	Acrolein	107-02-8	Nasal lesions	mg /m3	2x10-5	LOAEL (HEC)	0.02	Medium	0364
12	Acrylamide	79-06-1	Degenerative nerve changes	mg /m3	0.006	HEC (BMDL)	0.18	Medium	0286
13	Acrylic acid	79-10-7	Degeneration of the nasal olfactory epithelium	mg /m3	1x10-3	LOAEL (HEC)	0.33	Medium	0002
14	Acrylonitrile	107-13-1	Degeneration and inflammation of nasal respiratory epithelium; hyperplasia of mucous secreting cells	mg /m3	2x10-3	LOAEL (HEC)	1.9	Medium	0206
15	Adiponitrile	111-69-3	Not Assessed under the IRIS program.
16	Alachlor	15972-60-8	Not Assessed under the IRIS program.
17	Alar	1596-84-5	Not Assessed under the IRIS program.
18	Aldicarb	116-06-3	Not Assessed under the IRIS program.
19	Aldicarb sulfone	1646-88-4	Not Assessed under the IRIS program.
20	Aldrin	309-00-2	Not Assessed under the IRIS program.
21	Ally	74223-64-6	Not Assessed under the IRIS program.
22	Allyl alcohol	107-18-6	Not Assessed under the IRIS program.
23	Allyl chloride	107-05-1	Functional and histological peripheral neurotoxicity	mg /m3	1x10-3	NOAEL (HEC)	3.6	Low	0387
24	Aluminum phosphide	20859-73-8	Not Assessed under the IRIS program.
25	Amdro	67485-29-4	Not Assessed under the IRIS program.
26	Ametryn	834-12-8	Not Assessed under the IRIS program.
27	4-Aminopyridine	504-24-5	Not Assessed under the IRIS program.
28	Amitraz	33089-61-1	Not Assessed under the IRIS program.
29	Ammonia	7664-41-7	Not Assessed under the IRIS program.
30	Ammonium acetate	631-61-8	Not Assessed under the IRIS program.
31	Ammonium methacrylate	16325-47-6	Not Assessed under the IRIS program.
32	Ammonium sulfamate	7773-06-0	Not Assessed under the IRIS program.
33	Aniline	62-53-3	Lack of toxicity (other effect: Mild spleen toxicity )	mg /m3	1x10-3	NOAEL (HEC)	3.4	Low	0350
34	ortho-Anisidine	90-04-0	Information reviewed but value not estimated. Refer to IRIS Summary.						0610
35	Anthracene	120-12-7	Not Assessed under the IRIS program.
36	Antimony	7440-36-0	Not Assessed under the IRIS program.
37	Antimony trioxide	1309-64-4	Pulmonary toxicity, chronic interstitial inflammation	mg /m3	2x10-4	BMC10 (HEC)	0.074	Medium	0676
38	Apollo	74115-24-5	Not Assessed under the IRIS program.
39	Aramite	140-57-8	Not Assessed under the IRIS program.
40	Aroclor 1016	12674-11-2	Not Assessed under the IRIS program.
41	Aroclor 1248	12672-29-6	Not Assessed under the IRIS program.
42	Aroclor 1254	11097-69-1	Not Assessed under the IRIS program.
43	Arsenic, inorganic	7440-38-2	Not Assessed under the IRIS program.
44	Arsine	7784-42-1	Increased hemolysis, abnormal RBC morphology, and increased spleen weight (other effect: Increased hemolysis, increased spleen weight, and impaired compensatory erythropoiesis)	mg /m3	5x10-5	NOAEL (HEC)	0.014	Medium	0672
45	Asbestos	1332-21-4	Not Assessed under the IRIS program.
46	Assure	76578-14-8	Not Assessed under the IRIS program.
47	Asulam		Not Assessed under the IRIS program.
48	Atrazine		Not Assessed under the IRIS program.
49	Avermectin B1		Not Assessed under the IRIS program.
50	Azobenzene		Not Assessed under the IRIS program.
51	Barium and Compounds		Not Assessed under the IRIS program.
52	Barium cyanide		Not Assessed under the IRIS program.
53	Baygon		Not Assessed under the IRIS program.
54	Bayleton		Not Assessed under the IRIS program.
55	Baythroid		Not Assessed under the IRIS program.
56	Benefin		Not Assessed under the IRIS program.
57	Benomyl		Not Assessed under the IRIS program.
58	Bentazon (Basagran)		Not Assessed under the IRIS program.
59	Benz[a]anthracene		Not Assessed under the IRIS program.
60	Benzaldehyde		Not Assessed under the IRIS program.
61	Benzene	71-43-2	Decreased lymphocyte count	mg /m3	3x10-2	BMCL	8.2	Medium	0276
62	Benzidine	92-87-5	Information reviewed but value not estimated. Refer to IRIS Summary.						0135
63	Benzo[a]pyrene (BaP)		Not Assessed under the IRIS program.
64	Benzo[b]fluoranthene		Not Assessed under the IRIS program.
65	Benzo[g,h,i]perylene		Not Assessed under the IRIS program.
66	Benzo[k]fluoranthene		Not Assessed under the IRIS program.
67	Benzoic acid		Not Assessed under the IRIS program.
68	Benzotrichloride		Not Assessed under the IRIS program.
69	Benzyl chloride	100-44-7	Information reviewed but value not estimated. Refer to IRIS Summary.						0393
70	Beryllium and compounds	7440-41-7	Beryllium sensitization and progression to CBD	mg /m3	2x10-5	LOAEL (HEC)	0.0002	Medium	0012
71	Bidrin		Not Assessed under the IRIS program.
72	Biphenthrin		Not Assessed under the IRIS program.
73	1,1-Biphenyl	92-52-4	Information reviewed but value not estimated. Refer to IRIS Summary.						0013
74	Bis(2-chloro-1-methylethyl) ether		Not Assessed under the IRIS program.
75	Bis(2-chloroethoxy)methane		Not Assessed under the IRIS program.
76	Bis(chloroethyl)ether (BCEE)	111-44-4	Information reviewed but value not estimated. Refer to IRIS Summary.						0137
77	Bis(chloromethyl)ether (BCME)	542-88-1	Information reviewed but value not estimated. Refer to IRIS Summary.						0375
78	Bisphenol A.	80-05-7	Not Assessed under the IRIS program.
79	Boron and Compounds		Information reviewed but value not estimated. Refer to IRIS Summary.						0410
80	Bromate	15541-45-4	Information reviewed but value not estimated. Refer to IRIS Summary.						1002
81	Brominated dibenzofurans	NA	Not Assessed under the IRIS program.
82	Bromobenzene	108-86-1	Hepatocellular cytomegaly in female B6C3F1 mice	mg /m3	6x10-2	BMCL10 (HEC)	63	Low/Medium	1020
83	Bromochloromethane		Not Assessed under the IRIS program.
84	Bromodichloromethane		Not Assessed under the IRIS program.
85	p-Bromodiphenyl ether		Not Assessed under the IRIS program.
86	Bromoform	75-25-2	Information reviewed but value not estimated. Refer to IRIS Summary.						0214
87	Bromomethane	74-83-9	Degenerative and proliferative lesions of the olfactory epithelium of the nasal cavity	mg /m3	5x10-3	LOAEL (HEC)	0.48	High	0015
88	Bromotrichloromethane		Not Assessed under the IRIS program.
89	Bromoxynil		Not Assessed under the IRIS program.
90	Bromoxynil octanoate		Not Assessed under the IRIS program.
91	1,3-Butadiene	106-99-0	Ovarian atrophy	mg /m3	2x10-3	BMCL10 (HEC)	1.98	Medium	0139
92	n-Butanol		Not Assessed under the IRIS program.
93	Butyl benzyl phthalate		Not Assessed under the IRIS program.
94	Butylate		Not Assessed under the IRIS program.
95	t-Butylchloride		Not Assessed under the IRIS program.
96	Butylphthalyl butylglycolate (BPBG)		Not Assessed under the IRIS program.
97	Cacodylic acid		Not Assessed under the IRIS program.
98	Cadmium		Not Assessed under the IRIS program.
99	Calcium cyanide		Not Assessed under the IRIS program.
100	Caprolactam	105-60-2	Information reviewed but value not estimated. Refer to IRIS Summary.						0357
101	Captafol		Not Assessed under the IRIS program.
102	Captan		Not Assessed under the IRIS program.
103	Carbaryl	63-25-2	Information reviewed but value not estimated. Refer to IRIS Summary.						0019
104	Carbofuran		Not Assessed under the IRIS program.
105	Carbon disulfide	75-15-0	Peripheral nervous system dysfunction	mg /m3	7x10-1	BMC10 (HEC)	19.7	Medium	0217
106	Carbon tetrachloride	56-23-5	Not Assessed under the IRIS program.	Fatty changes in the liver	mg /m3	0.1	BMCL10 (HEC)	14.3	0020
107	Carbonyl sulfide	463-58-1	Information reviewed but value not estimated. Refer to IRIS Summary.						0617
108	Carbosulfan		Not Assessed under the IRIS program.
109	Carboxin		Not Assessed under the IRIS program.
110	Cerium Oxide and Cerium Compounds	1306-38-3	Increased incidence of alveolar epithelial hyperplasia in the lungs of male and female rats	mg /m3	9x10-4	BMCL (HEC)	0.86	Low	1018
111	Chloral hydrate		Not Assessed under the IRIS program.
112	Chloramben		Not Assessed under the IRIS program.
113	Chlordane (Technical)	12789-03-6	Hepatic effects	mg /m3	7x10-4	NOAEL (HEC)	0.65	Low	0142
114	Chlordecone (Kepone)	143-50-0	Information reviewed but value not estimated. Refer to IRIS Summary.						1017
115	Chlorimuron-ethyl		Not Assessed under the IRIS program.
116	Chlorine		Not Assessed under the IRIS program.
117	Chlorine cyanide		Not Assessed under the IRIS program.
118	Chlorine dioxide	10049-04-4	Vascular congestion and peribronchial edema (other effect: Hemorrhagic alveoli and congested capillaries in the lungs)	mg /m3	2x10-4	LOAEL (HEC)	0.64	Low	0496
119	Chlorite (sodium salt)	7758-19-2	Information reviewed but value not estimated. Refer to IRIS Summary.						0648
120	1-Chloro-1,1-difluoroethane	75-68-3	No adverse effects	mg /m3	5x101	NOAEL (HEC)	14710	Medium	0661
121	2-Chloroacetophenone	532-27-4	Squamous hyperplasia of the nasal respiratory epithelium	mg /m3	3x10-5	LOAEL (HEC)	0.03	Low	0537
122	p-Chloroaniline		Not Assessed under the IRIS program.
123	Chlorobenzene		Not Assessed under the IRIS program.
124	Chlorobenzilate		Not Assessed under the IRIS program.
125	1-Chlorobutane		Not Assessed under the IRIS program.
126	2-Chlorobutane		Not Assessed under the IRIS program.
127	Chlorocyclopentadiene		Not Assessed under the IRIS program.
128	Chlorodifluoromethane	75-45-6	Increased kidney, adrenal and pituitary weights (other effect: Reduced maternal weight gain)	mg /m3	5x101	NOAEL (HEC)	5260	Medium	0657
129	Chloroform		Not Assessed under the IRIS program.
130	Chloromethyl methyl ether (CMME)		Not Assessed under the IRIS program.
131	beta-Chloronaphthalene		Not Assessed under the IRIS program.
132	2-Chlorophenol		Not Assessed under the IRIS program.
133	p-Chlorophenyl methyl sulfide		Not Assessed under the IRIS program.
134	p-Chlorophenyl methyl sulfone		Not Assessed under the IRIS program.
135	p-Chlorophenyl methyl sulfoxide		Not Assessed under the IRIS program.
136	Chloroprene	126-99-8	Increase in incidence of olfactory atrophy, alveolar hyperplasia, and splenic hematopoietic proliferation in male F344/N rats, female F344/N rats, and female B6C3F1 mice, respectively	mg /m3	2x10-2	BMDL (HEC)	2	Medium/High	1021
137	Chlorothalonil		Not Assessed under the IRIS program.
138	o-Chlorotoluene		Not Assessed under the IRIS program.
139	Chlorpropham		Not Assessed under the IRIS program.
140	Chlorpyrifos		Not Assessed under the IRIS program.
141	Chlorsulfuron		Not Assessed under the IRIS program.
142	Chromium(III), insoluble salts	16065-83-1	Information reviewed but value not estimated. Refer to IRIS Summary.						0028
143	Chromium(VI) (Chromic acid mists and dissolved Cr(VI) aerosols)	18540-29-9	Nasal septum atrophy	mg /m3	8x10-6	LOAEL (ADJ)	0.000714	Low	0144
144	Chromium(VI) (Cr(VI) particulates)	18540-29-9	Lactate dehydrogenase in bronchioalveolar lavage fluid		1x10-4	BMC10 (ADJ)	0.034	Medium	0144
145	Chrysene		Not Assessed under the IRIS program.
146	Coke oven emissions		Not Assessed under the IRIS program.
147	Copper		Not Assessed under the IRIS program.
148	Copper cyanide		Not Assessed under the IRIS program.
149	Creosote		Not Assessed under the IRIS program.
150	Crotonaldehyde		Not Assessed under the IRIS program.
151	Cumene	98-82-8	Increased kidney weights in female rats and adrenal weights in male and female rats	mg /m3	4x10-1	NOAEL (HEC)	435	Medium	0306
152	Cyanazine		Not Assessed under the IRIS program.
153	Cyanide, free		Not Assessed under the IRIS program.
154	Cyanogen		Not Assessed under the IRIS program.
155	Cyanogen bromide		Not Assessed under the IRIS program.
156	Cyclohexane	110-82-7	Reduced pup weights in the F1 and F2 generations	mg /m3	6	BMCL1sd (HEC)	1822	Low/Medium	1005
157	Cyclohexanone		Not Assessed under the IRIS program.
158	Cyclohexylamine		Not Assessed under the IRIS program.
159	Cyhalothrin/Karate		Not Assessed under the IRIS program.
160	Cypermethrin		Not Assessed under the IRIS program.
161	Cyromazine		Not Assessed under the IRIS program.
162	Dacthal		Not Assessed under the IRIS program.
163	Dalapon, sodium salt		Not Assessed under the IRIS program.
164	Danitol		Not Assessed under the IRIS program.
165	2,2',3,3',4,4',5,5',6,6'-Decabromodiphenyl ether (BDE-209)	1163-19-5	Information reviewed but value not estimated. Refer to IRIS Summary.						0035
166	Demeton		Not Assessed under the IRIS program.
167	Di (2-ethylhexyl)phthalate (DEHP)		Not Assessed under the IRIS program.
168	Di(2-ethylhexyl)adipate		Not Assessed under the IRIS program.
169	2,4-Diaminotoluene	95-80-7	Information reviewed but value not estimated. Refer to IRIS Summary.						0536
170	Diazomethane	334-88-3	Information reviewed but value not estimated. Refer to IRIS Summary.						0616
171	Dibenz[a,h]anthracene		Not Assessed under the IRIS program.
172	Dibenzofuran		Not Assessed under the IRIS program.
173	1,2-Dibromo-3-chloropropane (DBCP)	96-12-8	Testicular effects	mg /m3	2x10-4	NOAEL (HEC)	0.17	Medium	0414
174	1,4-Dibromobenzene		Not Assessed under the IRIS program.
175	Dibromochloromethane		Not Assessed under the IRIS program.
176	Dibromodichloromethane		Not Assessed under the IRIS program.
177	p,p'-Dibromodiphenyl ether		Not Assessed under the IRIS program.
178	1,2-Dibromoethane	106-93-4	Nasal inflammation	mg /m3	9x10-3	BMCL10 (HEC)	2.8	Medium	0361
179	Dibutyl phthalate	84-74-2	Information reviewed but value not estimated. Refer to IRIS Summary.						0038
180	Dicamba		Not Assessed under the IRIS program.
181	Dichloroacetic acid	79-43-6	Information reviewed but value not estimated. Refer to IRIS Summary.						0654
182	1,3-Dichlorobenzene		Not Assessed under the IRIS program.
183	1,4-Dichlorobenzene	106-46-7	Increased liver weights in P1 males	mg /m3	8x10-1	NOAEL (HEC)	75	Medium	0552
184	1,2-Dichlorobenzene		Not Assessed under the IRIS program.
185	3,3'-Dichlorobenzidine	91-94-1	Information reviewed but value not estimated. Refer to IRIS Summary.						0504
186	Dichlorodifluoromethane		Not Assessed under the IRIS program.
187	p,p'-Dichlorodiphenyl dichloroethane (DDD)		Not Assessed under the IRIS program.
188	p,p'-Dichlorodiphenyldichloroethylene (DDE)		Not Assessed under the IRIS program.
189	p,p'-Dichlorodiphenyltrichloroethane (DDT)		Not Assessed under the IRIS program.
190	1,2-Dichloroethane		Not Assessed under the IRIS program.
191	1,1-Dichloroethane		Not Assessed under the IRIS program.
192	trans-1,2-Dichloroethylene	156-60-5	Information reviewed but value not estimated. Refer to IRIS Summary.						0314
193	cis-1,2-Dichloroethylene	156-59-2	Information reviewed but value not estimated. Refer to IRIS Summary.						0418
194	1,1-Dichloroethylene (1,1-DCE)	75-35-4	Liver toxicity (fatty change)	mg /m3	2x10-1	BMCL10 (HEC)	6.9	Medium	0039
195	Dichloromethane	75-09-2	Hepatic effects (hepatic vacuolation)	mg /m3	6x10-1	BMDL10 (HEC)	17.2	Medium/High	0070
196	2,4-Dichlorophenol		Not Assessed under the IRIS program.
197	4-(2,4-Dichlorophenoxy)butyric acid (2,4-DB)		Not Assessed under the IRIS program.
198	2,4-Dichlorophenoxyacetic acid (2,4-D)		Not Assessed under the IRIS program.
199	1,2-Dichloropropane	78-87-5	Hyperplasia of the nasal mucosa	mg /m3	4x10-3	LOAEL (HEC)	1.3	Medium	0601
200	2,3-Dichloropropanol		Not Assessed under the IRIS program.
201	1,3-Dichloropropene	542-75-6	Hypertrophy/ hyperplasia of the nasal respiratory epithelium	mg /m3	2x10-2	BMCL10 (HEC)	0.72	High	0224
202	Dichlorvos	62-73-7	Decreased brain cholinesterase activity	mg /m3	5x10-4	NOAEL (HEC)	0.05	Medium	0151
203	Dicofol		Not Assessed under the IRIS program.
204	Dieldrin		Not Assessed under the IRIS program.
205	Diesel engine exhaust	NA	Pulmonary inflammation and histopathology	mg /m3	5x10-3	NOAEL (HEC)	0.144	Medium	0642
206	Diethyl phthalate		Not Assessed under the IRIS program.
207	Diethyl sulfate	64-67-5	Information reviewed but value not estimated. Refer to IRIS Summary.						0615
208	Diethyl-p-nitrophenylphosphate		Not Assessed under the IRIS program.
209	Diethylene glycol dinitrate (DEGDN)		Not Assessed under the IRIS program.
210	Difenzoquat		Not Assessed under the IRIS program.
211	Diflubenzuron		Not Assessed under the IRIS program.
212	1,1-Difluoroethane	75-37-6	No adverse effects observed	mg /m3	4x101	NOAEL (HEC)	12051	Medium	0665
213	Diisopropyl methylphosphonate (DIMP)		Not Assessed under the IRIS program.
214	Dimethipin		Not Assessed under the IRIS program.
215	Dimethoate		Not Assessed under the IRIS program.
216	Dimethyl phthalate	131-11-3	Information reviewed but value not estimated. Refer to IRIS Summary.						0353
217	Dimethyl sulfate	77-78-1	Information reviewed but value not estimated. Refer to IRIS Summary.						0365
218	Dimethyl terephthalate (DMT)		Not Assessed under the IRIS program.
219	Dimethylamine	124-40-3	Information reviewed but value not estimated. Refer to IRIS Summary.						0228
220	N-N-Dimethylaniline		Not Assessed under the IRIS program.
221	3,3-Dimethylbenzidine	119-93-7	Information reviewed but value not estimated. Refer to IRIS Summary.						0538
222	N,N-Dimethylformamide	68-12-2	Digestive disturbances and minimal hepatic changes suggestive of liver abnormalities	mg /m3	3x10-2	LOAEL (HEC)	7.9	Medium	0511
223	3,4-Dimethylphenol		Not Assessed under the IRIS program.
224	2,6-Dimethylphenol		Not Assessed under the IRIS program.
225	2,4-Dimethylphenol		Not Assessed under the IRIS program.
226	4,6-Dinitro-o-cyclohexyl phenol		Not Assessed under the IRIS program.
227	m-Dinitrobenzene		Not Assessed under the IRIS program.
228	o-Dinitrobenzene		Not Assessed under the IRIS program.
229	2,4-Dinitrophenol	51-28-5	Information reviewed but value not estimated. Refer to IRIS Summary.						0152
230	2,4-Dinitrotoluene	121-14-2	Information reviewed but value not estimated. Refer to IRIS Summary.						0542
231	2,4-/2,6-Dinitrotoluene mixture		Not Assessed under the IRIS program.
232	Dinoseb		Not Assessed under the IRIS program.
233	1,4-Dioxane	123-91-1	Information reviewed but value not estimated. Refer to IRIS Summary.						0326
234	Diphenamid		Not Assessed under the IRIS program.
235	Diphenylamine		Not Assessed under the IRIS program.
236	1,2-Diphenylhydrazine	122-66-7	Information reviewed but value not estimated. Refer to IRIS Summary.						0049
237	Diquat		Not Assessed under the IRIS program.
238	Disulfoton		Not Assessed under the IRIS program.
239	1,4-Dithiane		Not Assessed under the IRIS program.
240	Diuron		Not Assessed under the IRIS program.
241	Dodine		Not Assessed under the IRIS program.
242	Endosulfan		Not Assessed under the IRIS program.
243	Endothall		Not Assessed under the IRIS program.
244	Endrin		Not Assessed under the IRIS program.
245	Epichlorohydrin	106-89-8	Changes in the nasal turbinates	mg /m3	1x10-3	NOAEL (HEC)	0.36	Medium	0050
246	1,2-Epoxybutane (EBU)	106-88-7	Degenerative lesions of the nasal cavity	mg /m3	2x10-2	LOAEL (HEC)	4.8	Medium	0630
247	Ethephon		Not Assessed under the IRIS program.
248	Ethion		Not Assessed under the IRIS program.
249	2-Ethoxyethanol	110-80-5	Decreased testis weight, seminiferous tubule degeneration and decreased hemoglobin	mg /m3	2x10-1	NOAEL (HEC)	68	Medium	0513
250	Ethyl acetate		Not Assessed under the IRIS program.
251	Ethyl carbamate	51-79-6	Information reviewed but value not estimated. Refer to IRIS Summary.						0629
252	Ethyl chloride	75-00-3	Delayed fetal ossification	mg /m3	1x101<7sup>	NOAEL (HEC)	4000	Medium	0523
253	S-Ethyl dipropylthiocarbamate (EPTC)		Not Assessed under the IRIS program.
254	Ethyl ether		Not Assessed under the IRIS program.
255	Ethyl p-nitrophenyl phenylphosphorothioate (EPN)		Not Assessed under the IRIS program.
256	Ethylbenzene	100-41-4	Developmental toxicity	mg /m3	1	NOAEL (HEC)	434	Low	0051
257	Ethylene diamine	107-15-3	Information reviewed but value not estimated. Refer to IRIS Summary.						0528
258	Ethylene glycol		Not Assessed under the IRIS program.
259	Ethylene glycol monobutyl ether (EGBE) (2-Butoxyethanol)	111-76-2	Hemosiderin deposition in the liver	mg /m3	1.6	BMCL (HEC)	16	Medium/High	0500
260	Ethylene thiourea (ETU)		Not Assessed under the IRIS program.
261	Ethyleneimine	151-56-4	Information reviewed but value not estimated. Refer to IRIS Summary.						0631
262	Ethylphthalyl ethylglycolate (EPEG)		Not Assessed under the IRIS program.
263	Express		Not Assessed under the IRIS program.
264	Fenamiphos		Not Assessed under the IRIS program.
265	Fluometuron		Not Assessed under the IRIS program.
266	Fluoranthene		Not Assessed under the IRIS program.
267	Fluorene		Not Assessed under the IRIS program.
268	Fluorine (soluble fluoride)		Not Assessed under the IRIS program.
269	Fluridone		Not Assessed under the IRIS program.
270	Flurprimidol		Not Assessed under the IRIS program.
271	Flutolanil		Not Assessed under the IRIS program.
272	Fluvalinate		Not Assessed under the IRIS program.
273	Folpet		Not Assessed under the IRIS program.
274	Fomesafen		Not Assessed under the IRIS program.
275	Fonofos		Not Assessed under the IRIS program.
276	Formaldehyde		Not Assessed under the IRIS program.
277	Formic acid		Not Assessed under the IRIS program.
278	Fosetyl-al		Not Assessed under the IRIS program.
279	Furan		Not Assessed under the IRIS program.
280	Furfural		Not Assessed under the IRIS program.
281	Furmecyclox		Not Assessed under the IRIS program.
282	Glufosinate-ammonium		Not Assessed under the IRIS program.
283	Glycidaldehyde		Not Assessed under the IRIS program.
284	Glyphosate		Not Assessed under the IRIS program.
285	Haloxyfop-methyl		Not Assessed under the IRIS program.
286	Harmony		Not Assessed under the IRIS program.
287	Heptachlor		Not Assessed under the IRIS program.
288	Heptachlor epoxide		Not Assessed under the IRIS program.
289	n-Heptane		Not Assessed under the IRIS program.
290	Hexabromobenzene		Not Assessed under the IRIS program.
291	Hexabromodiphenyl ether		Not Assessed under the IRIS program.
292	2,2',4,4',5,5'-Hexabromodiphenyl ether (BDE-153)	68631-49-2	Information reviewed but value not estimated. Refer to IRIS Summary.						1009
293	Hexachlorobenzene	118-74-1	Information reviewed but value not estimated. Refer to IRIS Summary.						0374
294	Hexachlorobutadiene		Not Assessed under the IRIS program.
295	alpha-Hexachlorocyclohexane (alpha-HCH)		Not Assessed under the IRIS program.
296	beta-Hexachlorocyclohexane (beta-HCH)		Not Assessed under the IRIS program.
297	delta-Hexachlorocyclohexane (delta-HCH)		Not Assessed under the IRIS program.
298	epsilon-Hexachlorocyclohexane (epsilon-HC)		Not Assessed under the IRIS program.
299	gamma-Hexachlorocyclohexane (gamma-HCH)		Not Assessed under the IRIS program.
300	technical Hexachlorocyclohexane (t-HCH)		Not Assessed under the IRIS program.
301	Hexachlorocyclopentadiene (HCCPD)	77-47-4	Suppurative inflammation of the nose	mg /m3	2x10-4	NOAEL (HEC)	0.024	Medium	0059
302	Hexachlorodibenzo-p-dioxin (HxCDD), mixture of 1,2,3,6,7,8-HxCDD and 1,2,3,7,8,9-HxCDD		Not Assessed under the IRIS program.
303	Hexachloroethane	67-72-1	Neurotoxicity (tremors and ruffled pelt)	mg /m3	3x10-2	NOAEL (HEC)	83	Low	0167
304	Hexachlorophene		Not Assessed under the IRIS program.
305	Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)		Not Assessed under the IRIS program.
306	1,6-Hexamethylene diisocyanate		Not Assessed under the IRIS program.
307	n-Hexane		Not Assessed under the IRIS program.
308	2-Hexanone		Not Assessed under the IRIS program.
309	Hexazinone		Not Assessed under the IRIS program.
310	Hydrazine/Hydrazine sulfate		Not Assessed under the IRIS program.
311	Hydrogen Cyanide and Cyanide Salts		Not Assessed under the IRIS program.
312	Hydrogen chloride		Not Assessed under the IRIS program.
313	Hydrogen sulfide		Not Assessed under the IRIS program.
314	Hydroquinone		Not Assessed under the IRIS program.
315	Imazalil		Not Assessed under the IRIS program.
316	Imazaquin		Not Assessed under the IRIS program.
317	Indeno[1,2,3-cd]pyrene		Not Assessed under the IRIS program.
318	Iprodione		Not Assessed under the IRIS program.
319	Isobutyl alcohol		Not Assessed under the IRIS program.
320	Isophorone		Not Assessed under the IRIS program.
321	Isopropalin		Not Assessed under the IRIS program.
322	Isopropyl methyl phosphonic acid (IMPA)		Not Assessed under the IRIS program.
323	Isoxaben		Not Assessed under the IRIS program.
324	Lactofen		Not Assessed under the IRIS program.
325	Lead and compounds (inorganic)		Not Assessed under the IRIS program.
326	d-Limonene		Not Assessed under the IRIS program.
327	Linuron		Not Assessed under the IRIS program.
328	Londax		Not Assessed under the IRIS program.
329	Malathion		Not Assessed under the IRIS program.
330	Maleic anhydride		Not Assessed under the IRIS program.
331	Maleic hydrazide		Not Assessed under the IRIS program.
332	Maneb		Not Assessed under the IRIS program.
333	Manganese		Not Assessed under the IRIS program.
334	Mepiquat chloride		Not Assessed under the IRIS program.
335	Mercuric chloride (HgCl2)		Not Assessed under the IRIS program.
336	Mercury, elemental		Not Assessed under the IRIS program.
337	Merphos		Not Assessed under the IRIS program.
338	Merphos oxide		Not Assessed under the IRIS program.
339	Metalaxyl		Not Assessed under the IRIS program.
340	Methacrylonitrile		Not Assessed under the IRIS program.
341	Methamidophos		Not Assessed under the IRIS program.
342	Methanol		Not Assessed under the IRIS program.
343	Methidathion		Not Assessed under the IRIS program.
344	Methomyl		Not Assessed under the IRIS program.
345	Methoxychlor		Not Assessed under the IRIS program.
346	2-Methoxyethanol		Not Assessed under the IRIS program.
347	Methyl acrylate		Not Assessed under the IRIS program.
348	Methyl chloride		Not Assessed under the IRIS program.
349	Methyl chlorocarbonate		Not Assessed under the IRIS program.
350	Methyl ethyl ketone (MEK)		Not Assessed under the IRIS program.
351	Methyl iodide		Not Assessed under the IRIS program.
352	Methyl isobutyl ketone (MIBK)		Not Assessed under the IRIS program.
353	Methyl isocyanate		Not Assessed under the IRIS program.
354	Methyl methacrylate		Not Assessed under the IRIS program.
355	Methyl parathion		Not Assessed under the IRIS program.
356	Methyl tert-butyl ether (MTBE)		Not Assessed under the IRIS program.
357	4-(2-Methyl-4-chlorophenoxy) butyric acid (MCPB)		Not Assessed under the IRIS program.
358	2-(2-Methyl-4-chlorophenoxy)propionic acid (MCPP)		Not Assessed under the IRIS program.
359	2-Methyl-4-chlorophenoxyacetic acid (MCPA)		Not Assessed under the IRIS program.
360	Methylene Diphenyl Diisocyanate (monomeric MDI) and polymeric MDI (PMDI)		Not Assessed under the IRIS program.
361	4,4'-Methylene bis(N,N'-dimethyl)aniline		Not Assessed under the IRIS program.
362	Methylmercury (MeHg)		Not Assessed under the IRIS program.
363	2-Methylnaphthalene		Not Assessed under the IRIS program.
364	4-Methylphenol		Not Assessed under the IRIS program.
365	3-Methylphenol		Not Assessed under the IRIS program.
366	2-Methylphenol		Not Assessed under the IRIS program.
367	Metolachlor		Not Assessed under the IRIS program.
368	Metribuzin		Not Assessed under the IRIS program.
369	Mirex		Not Assessed under the IRIS program.
370	Molinate		Not Assessed under the IRIS program.
371	Molybdenum		Not Assessed under the IRIS program.
372	Monochloramine		Not Assessed under the IRIS program.
373	Naled		Not Assessed under the IRIS program.
374	Naphthalene		Not Assessed under the IRIS program.
375	Napropamide		Not Assessed under the IRIS program.
376	Nickel carbonyl		Not Assessed under the IRIS program.
377	Nickel refinery dust		Not Assessed under the IRIS program.
378	Nickel subsulfide		Not Assessed under the IRIS program.
379	Nickel, soluble salts		Not Assessed under the IRIS program.
380	Nitrapyrin		Not Assessed under the IRIS program.
381	Nitrate		Not Assessed under the IRIS program.
382	Nitric oxide		Not Assessed under the IRIS program.
383	Nitrite		Not Assessed under the IRIS program.
384	Nitrobenzene		Not Assessed under the IRIS program.
385	Nitrogen dioxide		Not Assessed under the IRIS program.
386	Nitroguanidine		Not Assessed under the IRIS program.
387	p-Nitrophenol		Not Assessed under the IRIS program.
388	2-Nitropropane		Not Assessed under the IRIS program.
389	N-Nitroso-N-methylethylamine		Not Assessed under the IRIS program.
390	N-Nitroso-di-n-butylamine		Not Assessed under the IRIS program.
391	N-Nitrosodi-N-propylamine		Not Assessed under the IRIS program.
392	N-Nitrosodiethanolamine		Not Assessed under the IRIS program.
393	N-Nitrosodiethylamine		Not Assessed under the IRIS program.
394	N-Nitrosodimethylamine		Not Assessed under the IRIS program.
395	N-Nitrosodiphenylamine		Not Assessed under the IRIS program.
396	N-Nitrosopyrrolidine		Not Assessed under the IRIS program.
397	Nonabromodiphenyl ether		Not Assessed under the IRIS program.
398	Norflurazon		Not Assessed under the IRIS program.
399	NuStar		Not Assessed under the IRIS program.
400	Octabromodiphenyl ether		Not Assessed under the IRIS program.
401	Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX)		Not Assessed under the IRIS program.
402	Oryzalin		Not Assessed under the IRIS program.
403	Oxadiazon		Not Assessed under the IRIS program.
404	Oxamyl		Not Assessed under the IRIS program.
405	Oxyfluorfen		Not Assessed under the IRIS program.
406	Paclobutrazol		Not Assessed under the IRIS program.
407	Paraquat		Not Assessed under the IRIS program.
408	Parathion		Not Assessed under the IRIS program.
409	Pendimethalin		Not Assessed under the IRIS program.
410	Pentabromodiphenyl ether		Not Assessed under the IRIS program.
411	2,2',4,4',5-Pentabromodiphenyl ether (BDE-99)		Not Assessed under the IRIS program.
412	Pentachlorobenzene		Not Assessed under the IRIS program.
413	Pentachlorocyclopentadiene		Not Assessed under the IRIS program.
414	Pentachloronitrobenzene (PCNB)		Not Assessed under the IRIS program.
415	Pentachlorophenol		Not Assessed under the IRIS program.
416	Pentafluoroethane		Not Assessed under the IRIS program.
417	Perchlorate (ClO4) and Perchlorate Salts		Not Assessed under the IRIS program.
418	Permethrin		Not Assessed under the IRIS program.
419	Phenanthrene		Not Assessed under the IRIS program.
420	Phenmedipham		Not Assessed under the IRIS program.
421	Phenol		Not Assessed under the IRIS program.
422	m-Phenylenediamine		Not Assessed under the IRIS program.
423	Phenylmercuric acetate		Not Assessed under the IRIS program.
424	Phosalone		Not Assessed under the IRIS program.
425	Phosgene		Not Assessed under the IRIS program.
426	Phosmet		Not Assessed under the IRIS program.
427	Phosphine		Not Assessed under the IRIS program.
428	Phosphoric acid		Not Assessed under the IRIS program.
429	Phthalic anhydride		Not Assessed under the IRIS program.
430	Picloram		Not Assessed under the IRIS program.
431	Pirimiphos-methyl		Not Assessed under the IRIS program.
432	Polychlorinated biphenyls (PCBs)		Not Assessed under the IRIS program.
433	Potassium cyanide		Not Assessed under the IRIS program.
434	Potassium silver cyanide		Not Assessed under the IRIS program.
435	Prochloraz		Not Assessed under the IRIS program.
436	Prometon		Not Assessed under the IRIS program.
437	Prometryn		Not Assessed under the IRIS program.
438	Pronamide		Not Assessed under the IRIS program.
439	Propachlor		Not Assessed under the IRIS program.
440	Propanil		Not Assessed under the IRIS program.
441	Propargite		Not Assessed under the IRIS program.
442	Propargyl alcohol		Not Assessed under the IRIS program.
443	Propazine		Not Assessed under the IRIS program.
444	Propham		Not Assessed under the IRIS program.
445	Propiconazole		Not Assessed under the IRIS program.
446	beta-Propiolactone		Not Assessed under the IRIS program.
447	Propionaldehyde		Not Assessed under the IRIS program.
448	Propylene glycol		Not Assessed under the IRIS program.
449	Propylene glycol monoethyl ether		Not Assessed under the IRIS program.
450	Propylene glycol monomethyl ether (PGME)		Not Assessed under the IRIS program.
451	Propylene oxide		Not Assessed under the IRIS program.
452	Propyleneimine		Not Assessed under the IRIS program.
453	Pursuit		Not Assessed under the IRIS program.
454	Pydrin		Not Assessed under the IRIS program.
455	Pyrene		Not Assessed under the IRIS program.
456	Pyridine		Not Assessed under the IRIS program.
457	Quinalphos		Not Assessed under the IRIS program.
458	Quinoline		Not Assessed under the IRIS program.
459	Quinone		Not Assessed under the IRIS program.
460	Radium 226,228		Not Assessed under the IRIS program.
461	Radon 222		Not Assessed under the IRIS program.
462	Refractory ceramic fibers		Not Assessed under the IRIS program.
463	Resmethrin		Not Assessed under the IRIS program.
464	Rotenone		Not Assessed under the IRIS program.
465	Savey		Not Assessed under the IRIS program.
466	Selenious acid		Not Assessed under the IRIS program.
467	Selenium and Compounds		Not Assessed under the IRIS program.
468	Selenium sulfide		Not Assessed under the IRIS program.
469	Selenourea		Not Assessed under the IRIS program.
470	Sethoxydim		Not Assessed under the IRIS program.
471	Silver		Not Assessed under the IRIS program.
472	Silver cyanide		Not Assessed under the IRIS program.
473	Simazine		Not Assessed under the IRIS program.
474	Sodium azide		Not Assessed under the IRIS program.
475	Sodium cyanide		Not Assessed under the IRIS program.
476	Sodium diethyldithiocarbamate		Not Assessed under the IRIS program.
477	Sodium fluoroacetate		Not Assessed under the IRIS program.
478	Strontium		Not Assessed under the IRIS program.
479	Strychnine		Not Assessed under the IRIS program.
480	Styrene		Not Assessed under the IRIS program.
481	Systhane		Not Assessed under the IRIS program.
482	Tebuthiuron		Not Assessed under the IRIS program.
483	Terbacil		Not Assessed under the IRIS program.
484	Terbutryn		Not Assessed under the IRIS program.
485	Tetrabromodiphenyl ether		Not Assessed under the IRIS program.
486	2,2',4,4'-Tetrabromodiphenyl ether (BDE-47)		Not Assessed under the IRIS program.
487	1,2,4,5-Tetrachlorobenzene		Not Assessed under the IRIS program.
488	Tetrachlorocyclopentadiene		Not Assessed under the IRIS program.
489	2,3,7,8-Tetrachlorodibenzo-p-dioxin		Not Assessed under the IRIS program.
490	1,1,1,2-Tetrachloroethane		Not Assessed under the IRIS program.
491	1,1,2,2-Tetrachloroethane		Not Assessed under the IRIS program.
492	Tetrachloroethylene		Not Assessed under the IRIS program.
493	2,3,4,6-Tetrachlorophenol		Not Assessed under the IRIS program.
494	Tetrachlorovinphos		Not Assessed under the IRIS program.
495	Tetraethyl lead		Not Assessed under the IRIS program.
496	Tetraethyldithiopyrophosphate		Not Assessed under the IRIS program.
497	1,1,1,2-Tetrafluoroethane		Not Assessed under the IRIS program.
498	Tetrahydrofuran		Not Assessed under the IRIS program.
499	Thallium (I), soluble salts		Not Assessed under the IRIS program.
500	Thallium acetate		Not Assessed under the IRIS program.
501	Thallium carbonate		Not Assessed under the IRIS program.
502	Thallium chloride		Not Assessed under the IRIS program.
503	Thallium nitrate		Not Assessed under the IRIS program.
504	Thallium oxide		Not Assessed under the IRIS program.
505	Thallium selenite		Not Assessed under the IRIS program.
506	Thallium(I) sulfate		Not Assessed under the IRIS program.
507	Thiobencarb		Not Assessed under the IRIS program.
508	Thiophanate-methyl		Not Assessed under the IRIS program.
509	Thiram		Not Assessed under the IRIS program.
510	Toluene		Not Assessed under the IRIS program.
511	2,4-/2,6-Toluene diisocyanate mixture (TDI)		Not Assessed under the IRIS program.
512	Toxaphene		Not Assessed under the IRIS program.
513	Tralomethrin		Not Assessed under the IRIS program.
514	Triallate		Not Assessed under the IRIS program.
515	Triasulfuron		Not Assessed under the IRIS program.
516	1,2,4-Tribromobenzene		Not Assessed under the IRIS program.
517	Tribromochloromethane		Not Assessed under the IRIS program.
518	Tribromodiphenyl ether		Not Assessed under the IRIS program.
519	Tributyltin oxide (TBTO)		Not Assessed under the IRIS program.
520	1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113)		Not Assessed under the IRIS program.
521	Trichloroacetic acid		Not Assessed under the IRIS program.
522	1,2,4-Trichlorobenzene		Not Assessed under the IRIS program.
523	Trichlorocyclopentadiene		Not Assessed under the IRIS program.
524	1,1,2-Trichloroethane		Not Assessed under the IRIS program.
525	1,1,1-Trichloroethane		Not Assessed under the IRIS program.
526	Trichloroethylene		Not Assessed under the IRIS program.
527	Trichlorofluoromethane		Not Assessed under the IRIS program.
528	2,4,5-Trichlorophenol		Not Assessed under the IRIS program.
529	2,4,6-Trichlorophenol		Not Assessed under the IRIS program.
530	2(2,4,5-Trichlorophenoxy) propionic acid (2,4,5-TP)		Not Assessed under the IRIS program.
531	2,4,5-Trichlorophenoxyacetic acid (2,4,5-T)		Not Assessed under the IRIS program.
532	1,1,2-Trichloropropane		Not Assessed under the IRIS program.
533	1,2,3-Trichloropropane		Not Assessed under the IRIS program.
534	Tricresol		Not Assessed under the IRIS program.
535	Tridiphane		Not Assessed under the IRIS program.
536	Triethylamine		Not Assessed under the IRIS program.
537	Triethylene glycol monobutyl ether		Not Assessed under the IRIS program.
538	Triethylene glycol monoethyl ether		Not Assessed under the IRIS program.
539	Trifluralin		Not Assessed under the IRIS program.
540	2,2,4-Trimethylpentane		Not Assessed under the IRIS program.
541	1,3,5-Trinitrobenzene		Not Assessed under the IRIS program.
542	2,4,6-Trinitrotoluene (TNT)		Not Assessed under the IRIS program.
543	Uranium, natural		Not Assessed under the IRIS program.
544	Uranium, soluble salts		Not Assessed under the IRIS program.
545	Urea		Not Assessed under the IRIS program.
546	Vanadium pentoxide		Not Assessed under the IRIS program.
547	Vernam		Not Assessed under the IRIS program.
548	Vinclozolin		Not Assessed under the IRIS program.
549	Vinyl acetate		Not Assessed under the IRIS program.
550	Vinyl bromide		Not Assessed under the IRIS program.
551	Vinyl chloride		Not Assessed under the IRIS program.
552	Warfarin		Not Assessed under the IRIS program.
553	White phosphorus		Not Assessed under the IRIS program.
554	Xylenes		Not Assessed under the IRIS program.
555	Zinc and Compounds		Not Assessed under the IRIS program.
556	Zinc cyanide		Not Assessed under the IRIS program.
557	Zinc phosphide		Not Assessed under the IRIS program.
558	Zineb		Not Assessed under the IRIS program.

Inhalation unit risks

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IRIS(per µg /m

Obs	Substance	CASRN	Precursor Effect/ Tumor Type	Extrapolation Method	Unit	Inhalation unit risks	Study Route	IRIS identifier
1	Acenaphthene	83-32-9	Not Assessed under the IRIS program.
2	Acenaphthylene	208-96-8	Not Assessed under the IRIS program.
3	Acephate	30560-19-1	Not Assessed under the IRIS program.
4	Acetaldehyde	75-07-0	Nasal squamous cell carcinoma or adenocarcinoma	Linearized multistage-variable exposure input form (extra risk)	per µg/m3	2.2x10-6	Inhalation
5	Acetochlor	34256-82-1	Not Assessed under the IRIS program.
6	Acetone	67-64-1	Not Assessed under the IRIS program.
7	Acetonitrile	75-05-8	Not Assessed under the IRIS program.
8	Acetophenone	98-86-2	Not Assessed under the IRIS program.
9	Acetyl chloride	75-36-5	Not Assessed under the IRIS program.
10	Acifluorfen, sodium	62476-59-9	Not Assessed under the IRIS program.
11	Acrolein	107-02-8	Not Assessed under the IRIS program.
12	Acrylamide	79-06-1	thyroid tumors and tunica vaginalis mesotheliomas	Multistage model with linear extrapolation from the point of departure (BMDL), summed risk.	per µg /m3	1x10-4	Oral, drinking water
13	Acrylic acid	79-10-7	Not Assessed under the IRIS program.
14	Acrylonitrile	107-13-1	Respiratory cancer	Average relative risk		6.8x10-5	Inhalation
15	Adiponitrile	111-69-3	Not Assessed under the IRIS program.
16	Alachlor	15972-60-8	Not Assessed under the IRIS program.
17	Alar	1596-84-5	Not Assessed under the IRIS program.
18	Aldicarb	116-06-3	Not Assessed under the IRIS program.
19	Aldicarb sulfone	1646-88-4	Not Assessed under the IRIS program.
20	Aldrin	309-00-2	Liver carcinoma	Linearized multistage procedure, extra risk	4.9x10-3	Oral, Diet
21	Ally	74223-64-6	Not Assessed under the IRIS program.
22	Allyl alcohol	107-18-6	Not Assessed under the IRIS program.
23	Allyl chloride	107-05-1	Not Assessed under the IRIS program.
24	Aluminum phosphide	20859-73-8	Not Assessed under the IRIS program.
25	Amdro	67485-29-4	Not Assessed under the IRIS program.
26	Ametryn	834-12-8	Not Assessed under the IRIS program.
27	4-Aminopyridine	504-24-5	Not Assessed under the IRIS program.
28	Amitraz	33089-61-1	Not Assessed under the IRIS program.
29	Ammonia	7664-41-7	Not Assessed under the IRIS program.
30	Ammonium acetate	631-61-8	Not Assessed under the IRIS program.
31	Ammonium methacrylate	16325-47-6	Not Assessed under the IRIS program.
32	Ammonium sulfamate	7773-06-0	Not Assessed under the IRIS program.
33	Aniline	62-53-3	Not Assessed under the IRIS program.
34	ortho-Anisidine	90-04-0	Not Assessed under the IRIS program.
35	Anthracene	120-12-7	Not Assessed under the IRIS program.
36	Antimony	7440-36-0	Not Assessed under the IRIS program.
37	Antimony trioxide	1309-64-4	Not Assessed under the IRIS program.
38	Apollo	74115-24-5	Not Assessed under the IRIS program.
39	Aramite	140-57-8	Neoplastic liver nodules and carcinomas	Linearized multistage procedure, extra risk	per µg/m3	7.1x10-6	Oral, Diet
40	Aroclor 1016	12674-11-2	Not Assessed under the IRIS program.
41	Aroclor 1248	12672-29-6	Not Assessed under the IRIS program.
42	Aroclor 1254	11097-69-1	Not Assessed under the IRIS program.
43	Arsenic, inorganic	7440-38-2	Lung cancer	Absolute-risk linear model	per µg/m3	4.3x10-3	Inhalation, Occupational exposure
44	Arsine	7784-42-1	Not Assessed under the IRIS program.
45	Asbestos	1332-21-4	Lung cancer and mesothelioma Additive risk of lung cancer and mesothelioma, using relative risk model for lung cancer and absolute risk model for mesothelioma	per f/mL	2.3x10-1	Inhalation, Occupational exposure
46	Assure	76578-14-8	Not Assessed under the IRIS program.
47	Asulam	3337-71-1	Not Assessed under the IRIS program.
48	Atrazine	1912-24-9	Not Assessed under the IRIS program.
49	Avermectin B1	65195-55-3	Not Assessed under the IRIS program.
50	Azobenzene	103-33-3	Abdominal cavity sarcomas	Linearized multistage procedure, extra risk	per µg /m3	3.1x10-5	Oral, Diet
51	Barium and Compounds	7440-39-3	Not Assessed under the IRIS program.
52	Barium cyanide	542-62-1	Not Assessed under the IRIS program.
53	Baygon	114-26-1	Not Assessed under the IRIS program.
54	Bayleton	43121-43-3	Not Assessed under the IRIS program.
55	Baythroid	68359-37-5	Not Assessed under the IRIS program.
56	Benefin	1861-40-1	Not Assessed under the IRIS program.
57	Benomyl	17804-35-2	Not Assessed under the IRIS program.
58	Bentazon (Basagran)	25057-89-0	Not Assessed under the IRIS program.
59	Benz[a]anthracene	56-55-3	Not Assessed under the IRIS program.
60	Benzaldehyde	100-52-7	Not Assessed under the IRIS program.
61	Benzene	71-43-2	Leukemia	Low-dose linearity utilizing maximum likelihood estimates	per µg /m3	2.2x10-6	Inhalation
62	Benzene	71-43-2	Leukemia	Low-dose linearity utilizing maximum likelihood estimates	per µg /m3	7.8x10-6	Inhalation
63	Benzidine	92-87-5	Bladder tumors	One-hit with time factor, extra risk	per µg /m3	6.7x10-2	Inhalation, Occupational exposure
64	Benzo[a]pyrene (BaP)	50-32-8	Not Assessed under the IRIS program.
65	Benzo[b]fluoranthene	205-99-2	Not Assessed under the IRIS program.
66	Benzo[g,h,i]perylene	191-24-2	Not Assessed under the IRIS program.
67	Benzo[k]fluoranthene	207-08-9	Not Assessed under the IRIS program.
68	Benzoic acid	65-85-0	Not Assessed under the IRIS program.
69	Benzotrichloride	98-07-7	Not Assessed under the IRIS program.
70	Benzyl chloride	100-44-7	Not Assessed under the IRIS program.
71	Beryllium and compounds	7440-41-7	Lung cancer	Relative risk	per µg /m3	2.4x10-3	Inhalation, Occupational exposure
72	Bidrin	141-66-2	Not Assessed under the IRIS program.
73	Biphenthrin	82657-04-3	Not Assessed under the IRIS program.
74	1,1-Biphenyl	92-52-4	Not Assessed under the IRIS program.
75	Bis(2-chloro-1-methylethyl) ether	108-60-1	Not Assessed under the IRIS program.
76	Bis(2-chloroethoxy)methane	111-91-1	Not Assessed under the IRIS program.
77	Bis(chloroethyl)ether (BCEE)	111-44-4	Hepatomas	Linearized multistage procedure, extra risk	per µg /m3	3.3x10-4	Oral, Gavage followed by diet
78	Bis(chloromethyl)ether (BCME)	542-88-1	Respiratory tract tumors Linearized multistage procedure, extra risk	per µg /m3	6.2x10-2	Inhalation
79	Bisphenol A.	80-05-7	Not Assessed under the IRIS program.
80	Boron and Compounds	7440-42-8	Not Assessed under the IRIS program.
81	Bromate	15541-45-4	Information reviewed but value not estimated. Refer to IRIS Summary.
82	Brominated dibenzofurans	NA	Not Assessed under the IRIS program.
83	Bromobenzene	108-86-1	Not Assessed under the IRIS program.
84	Bromochloromethane	74-97-5	Not Assessed under the IRIS program.
85	Bromodichloromethane	75-27-4	Not Assessed under the IRIS program.
86	p-Bromodiphenyl ether	101-55-3	Not Assessed under the IRIS program.
87	Bromoform	75-25-2	Neoplastic lesions in the large intestine	Linearized multistage procedure, extra risk	per µg /m3	1.1x10-6	Oral, Gavage in corn oil
88	Bromomethane	74-83-9	Not Assessed under the IRIS program.
89	Bromotrichloromethane	75-62-7	Not Assessed under the IRIS program.
90	Bromoxynil	1689-84-5	Not Assessed under the IRIS program.
91	Bromoxynil octanoate	1689-99-2	Not Assessed under the IRIS program.
92	1,3-Butadiene	106-99-0	Leukemia	Linear extrapolation from LEC01 (0.254 ppm); LEC01 derived from linear relative rate model (RR = 1 + (B)(x)) using lifetable analysis with leukemia incidence data; an adjustment factor of 2 was applied.	per µg /m3	3x10-5 per	Inhalation
93	n-Butanol	71-36-3	Not Assessed under the IRIS program.
94	Butyl benzyl phthalate	85-68-7	Not Assessed under the IRIS program.
95	Butylate	2008-41-5	Not Assessed under the IRIS program.
96	t-Butylchloride	507-20-0	Not Assessed under the IRIS program.
97	Butylphthalyl butylglycolate (BPBG)	85-70-1	Not Assessed under the IRIS program.
98	Cacodylic acid	75-60-5	Not Assessed under the IRIS program.
99	Cadmium	7440-43-9	Lung, trachea, bronchus cancer deaths	Two stage; only first affected by exposure; extra risk	per µg /m3	1.8x10-3	Inhalation, Exposure in the workplace
100	Calcium cyanide	592-01-8	Not Assessed under the IRIS program.
101	Caprolactam	105-60-2	Not Assessed under the IRIS program.
102	Captafol	2425-06-1	Not Assessed under the IRIS program.
103	Captan	133-06-2	Not Assessed under the IRIS program.
104	Carbary	l63-25-2	Not Assessed under the IRIS program.
105	Carbofuran1	563-66-2	Not Assessed under the IRIS program.
106	Carbon disulfide	75-15-0	Not Assessed under the IRIS program.
107	Carbon tetrachloride	56-23-5	Pheochromocytoma	Log-probit model with linear extrapolation from the POD (LEC10).	per µg /m3	6x10-6	Inhalation
108	Carbonyl sulfide	463-58-1	Not Assessed under the IRIS program.
109	Carbosulfan	55285-14-8	Not Assessed under the IRIS program.
110	Carboxin	5234-68-4	Not Assessed under the IRIS program.
111	Cerium Oxide and Cerium Compounds	1306-38-3	Not Assessed under the IRIS program.
112	Chloral hydrate	302-17-0	Not Assessed under the IRIS program.
113	Chloramben	133-90-4	Not Assessed under the IRIS program.
114	Chlordane (Technical)	12789-03-6	Hepatocellular carcinoma	Linearized multistage procedure, extra risk	per µg /m3	1x10-4	Oral, Diet
115	Chlordecone (Kepone)	143-50-0	Information reviewed but value not estimated. Refer to IRIS Summary.
116	Chlorimuron-ethyl	90982-32-4	Not Assessed under the IRIS program.
117	Chlorine	7782-50-5	Not Assessed under the IRIS program.
118	Chlorine cyanide	506-77-4	Not Assessed under the IRIS program.
119	Chlorine dioxide	10049-04-4	Not Assessed under the IRIS program.
120	Chlorite (sodium salt)	7758-19-2	Not Assessed under the IRIS program.
121	1-Chloro-1,1-difluoroethane	75-68-3	Not Assessed under the IRIS program.
122	2-Chloroacetophenone	532-27-4	Not Assessed under the IRIS program.
123	p-Chloroaniline	106-47-8	Not Assessed under the IRIS program.
124	Chlorobenzene	108-90-7	Not Assessed under the IRIS program.
125	Chlorobenzilate	510-15-6	Not Assessed under the IRIS program.
126	1-Chlorobutane	109-69-3	Not Assessed under the IRIS program.
127	2-Chlorobutane	78-86-4	Not Assessed under the IRIS program.
128	Chlorocyclopentadiene	41851-50-7	Not Assessed under the IRIS program.
129	Chlorodifluoromethane	75-45-6	Not Assessed under the IRIS program.
130	Chloroform	67-66-3	Hepatocellular carcinoma	Linearized multistage procedure, extra risk	per µg /m3	2.3x10-5	Oral, Gavage
131	Chloromethyl methyl ether (CMME)	107-30-2	Not Assessed under the IRIS program.
132	beta-Chloronaphthalene	91-58-7	Not Assessed under the IRIS program.
133	2-Chlorophenol	95-57-8	Not Assessed under the IRIS program.
134	p-Chlorophenyl methyl sulfide	123-09-1	Not Assessed under the IRIS program.
135	p-Chlorophenyl methyl sulfone	98-57-7	Not Assessed under the IRIS program.
136	p-Chlorophenyl methyl sulfoxide	934-73-6	Not Assessed under the IRIS program.
137	Chloroprene	126-99-8	alveolar/ bronchiolar adenoma or carcinoma; hemangioma/ hemangiosarcoma (all organs); mammary gland adenocarcinoma, carcinoma, or adenoacanthoma; forestomach squamous cell papilloma or carcinoma; hepatocellular adenoma or carcinoma; Harderian gland adenoma or carcinoma; skin sarcoma; and Zymbal's gland carcinoma	Multistage model with linear extrapolation from the point of departure (BMDL), summed risk.	per µg /m3	3x10-4	Inhalation
138	Chlorothalonil	1897-45-6	Not Assessed under the IRIS program.
139	o-Chlorotoluene	95-49-8	Not Assessed under the IRIS program.
140	Chlorpropham	101-21-3	Not Assessed under the IRIS program.
141	Chlorpyrifos	2921-88-2	Not Assessed under the IRIS program.
142	Chlorsulfuron	64902-72-3	Not Assessed under the IRIS program.
143	Chromium(III), insoluble salts	16065-83-1	Not Assessed under the IRIS program.
144	Chromium(VI)	18540-29-9	Lung cancer	Multistage, extra risk	per µg /m3	1.2x10-2	Inhalation, Occupational exposure
145	Chrysene	218-01-9	Not Assessed under the IRIS program.
146	Coke oven emissions	8007-45-2	Respiratory cancer	Linearized multistage procedure	per µg /m3	6.2x10-4	Inhalation, Occupational
147	Copper	7440-50-8	Not Assessed under the IRIS program.
148	Copper cyanide	544-92-3	Not Assessed under the IRIS program.
149	Creosote	8001-58-9	Not Assessed under the IRIS program.
150	Crotonaldehyde	123-73-9	Not Assessed under the IRIS program.
151	Cumene	98-82-8	Not Assessed under the IRIS program.
152	Cyanazine	21725-46-2	Not Assessed under the IRIS program.
153	Cyanide, free	57-12-5	Not Assessed under the IRIS program.
154	Cyanogen	460-19-5	Not Assessed under the IRIS program.
155	Cyanogen bromide	506-68-3	Not Assessed under the IRIS program.
156	Cyclohexane	110-82-7	Not Assessed under the IRIS program.
157	Cyclohexanone	108-94-1	Not Assessed under the IRIS program.
158	Cyclohexylamine	108-91-8	Not Assessed under the IRIS program.
159	Cyhalothrin/Karate	68085-85-8	Not Assessed under the IRIS program.
160	Cypermethrin	52315-07-8	Not Assessed under the IRIS program.
161	Cyromazine	66215-27-8	Not Assessed under the IRIS program.
162	Dacthal	1861-32-1	Not Assessed under the IRIS program.
163	Dalapon, sodium salt	75-99-0	Not Assessed under the IRIS program.
164	Danitol	39515-41-8	Not Assessed under the IRIS program.
165	2,2',3,3',4,4',5,5',6,6'-Decabromodiphenyl ether (BDE-209) 1163-19-5 Not Assessed under the IRIS program.
166	Demeton 8065-48-3 Not Assessed under the IRIS program.
167	Di (2-ethylhexyl)phthalate (DEHP) 117-81-7 Not Assessed under the IRIS program.
168	Di(2-ethylhexyl)adipate 103-23-1 Not Assessed under the IRIS program.
169	2,4-Diaminotoluene 95-80-7 Not Assessed under the IRIS program.
170	Diazomethane 334-88-3 Not Assessed under the IRIS program.
171	Dibenz[a,h]anthracene 53-70-3 Not Assessed under the IRIS program.
172	Dibenzofuran 132-64-9 Not Assessed under the IRIS program.
173	1,2-Dibromo-3-chloropropane (DBCP) 96-12-8 Not Assessed under the IRIS program.
174	1,4-Dibromobenzene 106-37-6 Not Assessed under the IRIS program.
175	Dibromochloromethane 124-48-1 Not Assessed under the IRIS program.
176	Dibromodichloromethane 594-18-3 Not Assessed under the IRIS program.
177	p,p'-Dibromodiphenyl ether 2050-47-7 Not Assessed under the IRIS program.
178	1,2-Dibromoethane 106-93-4 Nasal cavity (includes adenoma, adenocarcinoma, papillary adenoma, squamous cell carcinoma, and or/papilloma), hemangiosarcomas, mesotheliomas Multistage-Weibull model; linear extrapolation from lower 95% confidence limit on dose associated with extra risk (adjusted for background) at point of departure at lower end of data range. 6x10-4 per µg/m3 2
179	3x10-4 per µg/m3 1
180	Inhalation
181
182	Dibutyl phthalate 84-74-2 Not Assessed under the IRIS program.
183	Dicamba 1918-00-9 Not Assessed under the IRIS program.
184	Dichloroacetic acid 79-43-6 Information reviewed but value not estimated. Refer to IRIS Summary.
185
186	1,3-Dichlorobenzene 541-73-1 Not Assessed under the IRIS program.
187	1,4-Dichlorobenzene 106-46-7 Not Assessed under the IRIS program.
188	1,2-Dichlorobenzene 95-50-1 Not Assessed under the IRIS program.
189	3,3'-Dichlorobenzidine 91-94-1 Not Assessed under the IRIS program.
190	Dichlorodifluoromethane 75-71-8 Not Assessed under the IRIS program.
191	p,p'-Dichlorodiphenyl dichloroethane (DDD) 72-54-8 Not Assessed under the IRIS program.
192	p,p'-Dichlorodiphenyldichloroethylene (DDE) 72-55-9 Not Assessed under the IRIS program.
193	p,p'-Dichlorodiphenyltrichloroethane (DDT) 50-29-3 Liver tumors, benign and malignant Linear multistage procedure, extra risk 9.7x10-5 per µg/m3
194	Oral,
195	Diet
196	1,2-Dichloroethane 107-06-2 Hemangiosarcomas Linearized multistage procedure, extra risk 2.6x10-5 per µg/m3
197	Oral,
198	Gavage
199	1,1-Dichloroethane 75-34-3 Not Assessed under the IRIS program.
200	trans-1,2-Dichloroethylene 156-60-5 Not Assessed under the IRIS program.
201	cis-1,2-Dichloroethylene 156-59-2 Not Assessed under the IRIS program.
202	1,1-Dichloroethylene (1,1-DCE) 75-35-4 Information reviewed but value not estimated. Refer to IRIS Summary.
203
204	Dichloromethane 75-09-2 Hepatocellular carcinomas or adenomas, bronchoalveolar carcinomas or adenomas Multistage model with linear extrapolation from the point of departure (BMDL10). 1x10-8 per µg/m3
205	Inhalation
206
207	2,4-Dichlorophenol 120-83-2 Not Assessed under the IRIS program.
208	4-(2,4-Dichlorophenoxy)butyric acid (2,4-DB) 94-82-6 Not Assessed under the IRIS program.
209	2,4-Dichlorophenoxyacetic acid (2,4-D) 94-75-7 Not Assessed under the IRIS program.
210	1,2-Dichloropropane 78-87-5 Not Assessed under the IRIS program.
211	2,3-Dichloropropanol 616-23-9 Not Assessed under the IRIS program.
212	1,3-Dichloropropene 542-75-6 Bronchioalveolar adenoma Linearized multistage model, extra risk 4x10-6 per µg/m3
213	Inhalation
214
215	Dichlorvos 62-73-7 Not Assessed under the IRIS program.
216	Dicofol 115-32-2 Not Assessed under the IRIS program.
217	Dieldrin 60-57-1 Liver carcinoma Linearized multistage procedure, extra risk 4.6x10-3 per µg/m3
218	Oral,
219	Diet
220	Diesel engine exhaust NA Information reviewed but value not estimated. Refer to IRIS Summary.
221
222	Diethyl phthalate 84-66-2 Not Assessed under the IRIS program.
223	Diethyl sulfate 64-67-5 Not Assessed under the IRIS program.
224	Diethyl-p-nitrophenylphosphate 311-45-5 Not Assessed under the IRIS program.
225	Diethylene glycol dinitrate (DEGDN) 693-21-0 Not Assessed under the IRIS program.
226	Difenzoquat 43222-48-6 Not Assessed under the IRIS program.
227	Diflubenzuron 35367-38-5 Not Assessed under the IRIS program.
228	1,1-Difluoroethane 75-37-6 Not Assessed under the IRIS program.
229	Diisopropyl methylphosphonate (DIMP) 1445-75-6 Not Assessed under the IRIS program.
230	Dimethipin 55290-64-7 Not Assessed under the IRIS program.
231	Dimethoate 60-51-5 Not Assessed under the IRIS program.
232	Dimethyl phthalate 131-11-3 Not Assessed under the IRIS program.
233	Dimethyl sulfate 77-78-1 Not Assessed under the IRIS program.
234	Dimethyl terephthalate (DMT) 120-61-6 Not Assessed under the IRIS program.
235	Dimethylamine 124-40-3 Not Assessed under the IRIS program.
236	N-N-Dimethylaniline 121-69-7 Not Assessed under the IRIS program.
237	3,3-Dimethylbenzidine 119-93-7 Not Assessed under the IRIS program.
238	N,N-Dimethylformamide 68-12-2 Not Assessed under the IRIS program.
239	3,4-Dimethylphenol 95-65-8 Not Assessed under the IRIS program.
240	2,6-Dimethylphenol 576-26-1 Not Assessed under the IRIS program.
241	2,4-Dimethylphenol 105-67-9 Not Assessed under the IRIS program.
242	4,6-Dinitro-o-cyclohexyl phenol 131-89-5 Not Assessed under the IRIS program.
243	m-Dinitrobenzene 99-65-0 Not Assessed under the IRIS program.
244	o-Dinitrobenzene 528-29-0 Not Assessed under the IRIS program.
245	2,4-Dinitrophenol 51-28-5 Not Assessed under the IRIS program.
246	2,4-Dinitrotoluene 121-14-2 Not Assessed under the IRIS program.
247	2,4-/2,6-Dinitrotoluene mixture NA Not Assessed under the IRIS program.
248	Dinoseb 88-85-7 Not Assessed under the IRIS program.
249	1,4-Dioxane 123-91-1 Information reviewed but value not estimated. Refer to IRIS Summary.
250
251	Diphenamid 957-51-7 Not Assessed under the IRIS program.
252	Diphenylamine 122-39-4 Not Assessed under the IRIS program.
253	1,2-Diphenylhydrazine 122-66-7 Hepatocellular carcinomas and neoplastic liver nodules Linearized multistage procedure, extra risk 2.2x10-4 per µg/m3
254	Oral,
255	Diet
256	Diquat 85-00-7 Not Assessed under the IRIS program.
257	Disulfoton 298-04-4 Not Assessed under the IRIS program.
258	1,4-Dithiane 505-29-3 Not Assessed under the IRIS program.
259	Diuron 330-54-1 Not Assessed under the IRIS program.
260	Dodine 2439-10-3 Not Assessed under the IRIS program.
261	Endosulfan 115-29-7 Not Assessed under the IRIS program.
262	Endothall 145-73-3 Not Assessed under the IRIS program.
263	Endrin 72-20-8 Not Assessed under the IRIS program.
264	Epichlorohydrin 106-89-8 Nasal cavity tumors Linearized multistage procedure, extra risk 1.2x10-6 per µg/m3
265	Inhalation
266
267	1,2-Epoxybutane (EBU) 106-88-7 Not Assessed under the IRIS program.
268	Ethephon 16672-87-0 Not Assessed under the IRIS program.
269	Ethion 563-12-2 Not Assessed under the IRIS program.
270	2-Ethoxyethanol 110-80-5 Not Assessed under the IRIS program.
271	Ethyl acetate 141-78-6 Not Assessed under the IRIS program.
272	Ethyl carbamate 51-79-6 Not Assessed under the IRIS program.
273	Ethyl chloride 75-00-3 Not Assessed under the IRIS program.
274	S-Ethyl dipropylthiocarbamate (EPTC) 759-94-4 Not Assessed under the IRIS program.
275	Ethyl ether 60-29-7 Not Assessed under the IRIS program.
276	Ethyl p-nitrophenyl phenylphosphorothioate (EPN) 2104-64-5 Not Assessed under the IRIS program.
277	Ethylbenzene 100-41-4 Not Assessed under the IRIS program.
278	Ethylene diamine 107-15-3 Not Assessed under the IRIS program.
279	Ethylene glycol 107-21-1 Not Assessed under the IRIS program.
280	Ethylene glycol monobutyl ether (EGBE) (2-Butoxyethanol) 111-76-2 Information reviewed but value not estimated. Refer to IRIS Summary.
281
282	Ethylene thiourea (ETU) 96-45-7 Not Assessed under the IRIS program.
283	Ethyleneimine 151-56-4 Not Assessed under the IRIS program.
284	Ethylphthalyl ethylglycolate (EPEG) 84-72-0 Not Assessed under the IRIS program.
285	Express 101200-48-0 Not Assessed under the IRIS program.
286	Fenamiphos 22224-92-6 Not Assessed under the IRIS program.
287	Fluometuron 2164-17-2 Not Assessed under the IRIS program.
288	Fluoranthene 206-44-0 Not Assessed under the IRIS program.
289	Fluorene 86-73-7 Not Assessed under the IRIS program.
290	Fluorine (soluble fluoride) 7782-41-4 Not Assessed under the IRIS program.
291	Fluridone 59756-60-4 Not Assessed under the IRIS program.
292	Flurprimidol 56425-91-3 Not Assessed under the IRIS program.
293	Flutolanil 66332-96-5 Not Assessed under the IRIS program.
294	Fluvalinate 69409-94-5 Not Assessed under the IRIS program.
295	Folpet 133-07-3 Not Assessed under the IRIS program.
296	Fomesafen 72178-02-0 Not Assessed under the IRIS program.
297	Fonofos 944-22-9 Not Assessed under the IRIS program.
298	Formaldehyde 50-00-0 Squamous cell carcinoma Linearized multistage procedure, additional risk 1.3x10-5 per µg/m3
299	Inhalation
300
301	Formic acid 64-18-6 Not Assessed under the IRIS program.
302	Fosetyl-al 39148-24-8 Not Assessed under the IRIS program.
303	Furan 110-00-9 Not Assessed under the IRIS program.
304	Furfural 98-01-1 Not Assessed under the IRIS program.
305	Furmecyclox 60568-05-0 Not Assessed under the IRIS program.
306	Glufosinate-ammonium 77182-82-2 Not Assessed under the IRIS program.
307	Glycidaldehyde 765-34-4 Not Assessed under the IRIS program.
308	Glyphosate 1071-83-6 Not Assessed under the IRIS program.
309	Haloxyfop-methyl 69806-40-2 Not Assessed under the IRIS program.
310	Harmony 79277-27-3 Not Assessed under the IRIS program.
311	Heptachlor 76-44-8 Hepatocellular carcinomas Linearized multistage procedure, extra risk 1.3x10-3 per µg/m3
312	Oral,
313	Diet
314	Heptachlor epoxide 1024-57-3 Hepatocellular carcinomas Linearized multistage procedure, extra risk 2.6x10-3 per µg/m3
315	Oral,
316	Diet
317	n-Heptane 142-82-5 Not Assessed under the IRIS program.
318	Hexabromobenzene 87-82-1 Not Assessed under the IRIS program.
319	Hexabromodiphenyl ether 36483-60-0 Not Assessed under the IRIS program.
320	2,2',4,4',5,5'-Hexabromodiphenyl ether (BDE-153) 68631-49-2 Not Assessed under the IRIS program.
321	Hexachlorobenzene 118-74-1 Hepatocellular carcinoma Linearized multistage, extra risk 4.6x10-4 per µg/m3
322	Oral,
323	Diet
324	Hexachlorobutadiene 87-68-3 Renal tubular adenomas and adenocarcinomas Linearized multistage procedure, extra risk 2.2x10-5 per µg/m3
325	Oral,
326	Diet
327	alpha-Hexachlorocyclohexane (alpha-HCH) 319-84-6 Hepatic nodules and hepatocellular carcinomas Linearized multistage procedure, extra risk 1.8x10-3 per µg/m3
328	Oral,
329	Diet
330	beta-Hexachlorocyclohexane (beta-HCH) 319-85-7 Hepatic nodules and hepatocellular carcinomas Linearized multistage procedure, extra risk 5.3x10-4 per µg/m3
331	Oral,
332	Diet
333	delta-Hexachlorocyclohexane (delta-HCH) 319-86-8 Not Assessed under the IRIS program.
334	epsilon-Hexachlorocyclohexane (epsilon-HC) 6108-10-7 Not Assessed under the IRIS program.
335	gamma-Hexachlorocyclohexane (gamma-HCH) 58-89-9 Not Assessed under the IRIS program.
336	technical Hexachlorocyclohexane (t-HCH) 608-73-1 Liver nodules and hepatocellular carcinomas Linearized multistage procedure 5.1x10-4 per µg/m3
337	Oral,
338	Diet
339	Hexachlorocyclopentadiene (HCCPD) 77-47-4 Not Assessed under the IRIS program.
340	Hexachlorodibenzo-p-dioxin (HxCDD), mixture of 1,2,3,6,7,8-HxCDD and 1,2,3,7,8,9-HxCDD 57653-85-7 Liver tumors (adenomas and carcinomas; neoplastic nodules and hepatocellular carcinomas) Linearized multistage procedure, extra risk 1.3 per µg/m3
341	Oral,
342	Gavage
343	Hexachloroethane 67-72-1 Information reviewed but value not estimated. Refer to IRIS Summary.
344
345	Hexachlorophene 70-30-4 Not Assessed under the IRIS program.
346	Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) 121-82-4 Not Assessed under the IRIS program.
347	1,6-Hexamethylene diisocyanate 822-06-0 Not Assessed under the IRIS program.
348	n-Hexane 110-54-3 Not Assessed under the IRIS program.
349	2-Hexanone 591-78-6 Not Assessed under the IRIS program.
350	Hexazinone 51235-04-2 Not Assessed under the IRIS program.
351	Hydrazine/Hydrazine sulfate	302-01-2	Nasal cavity adenoma or adenocarcinoma	Linearized multistage procedure, extra risk	per µg /m3	4.9x10-3	Inhalation
352	Hydrogen Cyanide and Cyanide Salts Various Not Assessed under the IRIS program.
353	Hydrogen chloride 7647-01-0 Not Assessed under the IRIS program.
354	Hydrogen sulfide 7783-06-4 Not Assessed under the IRIS program.
355	Hydroquinone 123-31-9 Not Assessed under the IRIS program.
356	Imazalil 35554-44-0 Not Assessed under the IRIS program.
357	Imazaquin 81335-37-7 Not Assessed under the IRIS program.
358	Indeno[1,2,3-cd]pyrene 193-39-5 Not Assessed under the IRIS program.
359	Iprodione 36734-19-7 Not Assessed under the IRIS program.
360	Isobutyl alcohol 78-83-1 Not Assessed under the IRIS program.
361	Isophorone 78-59-1 Not Assessed under the IRIS program.
362	Isopropalin 33820-53-0 Not Assessed under the IRIS program.
363	Isopropyl methyl phosphonic acid (IMPA) 1832-54-8 Not Assessed under the IRIS program.
364	Isoxaben 82558-50-7 Not Assessed under the IRIS program.
365	Lactofen 77501-63-4 Not Assessed under the IRIS program.
366	Lead and compounds (inorganic) 7439-92-1 Not Assessed under the IRIS program.
367	d-Limonene 5989-27-5 Not Assessed under the IRIS program.
368	Linuron 330-55-2 Not Assessed under the IRIS program.
369	Londax 83055-99-6 Not Assessed under the IRIS program.
370	Malathion 121-75-5 Not Assessed under the IRIS program.
371	Maleic anhydride 108-31-6 Not Assessed under the IRIS program.
372	Maleic hydrazide 123-33-1 Not Assessed under the IRIS program.
373	Maneb 12427-38-2 Not Assessed under the IRIS program.
374	Manganese 7439-96-5 Not Assessed under the IRIS program.
375	Mepiquat chloride 24307-26-4 Not Assessed under the IRIS program.
376	Mercuric chloride (HgCl2) 7487-94-7 Not Assessed under the IRIS program.
377	Mercury, elemental 7439-97-6 Not Assessed under the IRIS program.
378	Merphos 150-50-5 Not Assessed under the IRIS program.
379	Merphos oxide 78-48-8 Not Assessed under the IRIS program.
380	Metalaxyl 57837-19-1 Not Assessed under the IRIS program.
381	Methacrylonitrile 126-98-7 Not Assessed under the IRIS program.
382	Methamidophos 10265-92-6 Not Assessed under the IRIS program.
383	Methanol 67-56-1 Not Assessed under the IRIS program.
384	Methidathion 950-37-8 Not Assessed under the IRIS program.
385	Methomyl 16752-77-5 Not Assessed under the IRIS program.
386	Methoxychlor 72-43-5 Not Assessed under the IRIS program.
387	2-Methoxyethanol 109-86-4 Not Assessed under the IRIS program.
388	Methyl acrylate 96-33-3 Not Assessed under the IRIS program.
389	Methyl chloride 74-87-3 Not Assessed under the IRIS program.
390	Methyl chlorocarbonate 79-22-1 Not Assessed under the IRIS program.
391	Methyl ethyl ketone (MEK) 78-93-3 Not Assessed under the IRIS program.
392	Methyl iodide 74-88-4 Not Assessed under the IRIS program.
393	Methyl isobutyl ketone (MIBK) 108-10-1 Not Assessed under the IRIS program.
394	Methyl isocyanate 624-83-9 Not Assessed under the IRIS program.
395	Methyl methacrylate 80-62-6 Not Assessed under the IRIS program.
396	Methyl parathion 298-00-0 Not Assessed under the IRIS program.
397	Methyl tert-butyl ether (MTBE) 1634-04-4 Not Assessed under the IRIS program.
398	4-(2-Methyl-4-chlorophenoxy) butyric acid (MCPB) 94-81-5 Not Assessed under the IRIS program.
399	2-(2-Methyl-4-chlorophenoxy)propionic acid (MCPP) 93-65-2 Not Assessed under the IRIS program.
400	2-Methyl-4-chlorophenoxyacetic acid (MCPA) 94-74-6 Not Assessed under the IRIS program.
401	Methylene Diphenyl Diisocyanate (monomeric MDI) and polymeric MDI (PMDI)	101-68-8	Not Assessed under the IRIS program.
402	4,4'-Methylene bis(N,N'-dimethyl)aniline 101-61-1 Not Assessed under the IRIS program.
403	Methylmercury (MeHg) 22967-92-6 Not Assessed under the IRIS program.
404	2-Methylnaphthalene 91-57-6 Not Assessed under the IRIS program.
405	2-Methylphenol 95-48-7 Not Assessed under the IRIS program.
406	4-Methylphenol 106-44-5 Not Assessed under the IRIS program.
407	3-Methylphenol 108-39-4 Not Assessed under the IRIS program.
408	Metolachlor 51218-45-2 Not Assessed under the IRIS program.
409	Metribuzin 21087-64-9 Not Assessed under the IRIS program.
410	Mirex 2385-85-5 Not Assessed under the IRIS program.
411	Molinate 2212-67-1 Not Assessed under the IRIS program.
412	Molybdenum 7439-98-7 Not Assessed under the IRIS program.
413	Monochloramine 10599-90-3 Not Assessed under the IRIS program.
414	Naled 300-76-5 Not Assessed under the IRIS program.
415	Naphthalene 91-20-3 Information reviewed but value not estimated. Refer to IRIS Summary.
416	Napropamide 15299-99-7 Not Assessed under the IRIS program.
417	Nickel carbonyl 13463-39-3 Not Assessed under the IRIS program.
418	Nickel refinery dust	NA	Lung cancer	Additive and multiplicative	per µg /m3	2.4x10-4	Inhalation
419	Nickel subsulfide	12035-72-2	Lung cancer	Additive and multiplicative	per µg /m3	4.8x10-4	Inhalation
420	Nickel, soluble salts NA Not Assessed under the IRIS program.
421	Nitrapyrin 1929-82-4 Not Assessed under the IRIS program.
422	Nitrate 14797-55-8 Not Assessed under the IRIS program.
423	Nitric oxide 10102-43-9 Not Assessed under the IRIS program.
424	Nitrite 14797-65-0 Not Assessed under the IRIS program.
425	Nitrobenzene	98-95-3	Liver hepatocellular adenomas or carcinomas, kidney tubular adenomas or carcinomas, thyroid follicular cell adenomas or carcinomas	Multistage model with linear extrapolation from the POD (LEC10).	per µg /m3	4x10-5	Inhalation
426	Nitrogen dioxide 10102-44-0 Not Assessed under the IRIS program.
427	Nitroguanidine 556-88-7 Not Assessed under the IRIS program.
428	p-Nitrophenol 100-02-7 Not Assessed under the IRIS program.
429	2-Nitropropane 79-46-9 Not Assessed under the IRIS program.
430	N-Nitroso-N-methylethylamine 10595-95-6 Not Assessed under the IRIS program.
431	N-Nitroso-di-n-butylamine	924-16-3	Bladder and esophagus tumors	Linearized multistage procedure, extra risk	per µg /m3	1.6x10-3	Oral, Drinking water
432	N-Nitrosodi-N-propylamine 621-64-7 Not Assessed under the IRIS program.
433	N-Nitrosodiethanolamine 1116-54-7 Not Assessed under the IRIS program.
434	N-Nitrosodiethylamine	55-18-5	Liver tumors	Weibull, extra risk	4.3x10-2	Oral, Drinking water
435	N-Nitrosodimethylamine	62-75-9	Liver tumors	Weibull, extra risk	per µg /m3	1.4x10-2	Oral, Drinking water
436	N-Nitrosodiphenylamine 86-30-6 Not Assessed under the IRIS program.
437	N-Nitrosopyrrolidine	930-55-2	Hepatocellular carcinoma and adenoma	Linearized multistage procedure, extra risk	per µg /m3	6.1x10-4	Oral, Diet
438	Nonabromodiphenyl ether 63936-56-1 Not Assessed under the IRIS program.
439	Norflurazon 27314-13-2 Not Assessed under the IRIS program.
440	NuStar 85509-19-9 Not Assessed under the IRIS program.
441	Octabromodiphenyl ether 32536-52-0 Not Assessed under the IRIS program.
442	Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) 2691-41-0 Not Assessed under the IRIS program.
443	Oryzalin 19044-88-3 Not Assessed under the IRIS program.
444	Oxadiazon 19666-30-9 Not Assessed under the IRIS program.
445	Oxamyl 23135-22-0 Not Assessed under the IRIS program.
446	Oxyfluorfen 42874-03-3 Not Assessed under the IRIS program.
447	Paclobutrazol 76738-62-0 Not Assessed under the IRIS program.
448	Paraquat 1910-42-5 Not Assessed under the IRIS program.
449	Parathion 56-38-2 Not Assessed under the IRIS program.
450	Pendimethalin 40487-42-1 Not Assessed under the IRIS program.
451	Pentabromodiphenyl ether 32534-81-9 Not Assessed under the IRIS program.
452	2,2',4,4',5-Pentabromodiphenyl ether (BDE-99) 60348-60-9 Not Assessed under the IRIS program.
453	Pentachlorobenzene 608-93-5 Not Assessed under the IRIS program.
454	Pentachlorocyclopentadiene 25329-35-5 Not Assessed under the IRIS program.
455	Pentachloronitrobenzene (PCNB) 82-68-8 Not Assessed under the IRIS program.
456	Pentachlorophenol 87-86-5 Not Assessed under the IRIS program.
457	Pentafluoroethane 354-33-6 Not Assessed under the IRIS program.
458	Perchlorate (ClO4) and Perchlorate Salts 7790-98-9 Not Assessed under the IRIS program.
459	Permethrin 52645-53-1 Not Assessed under the IRIS program.
460	Phenanthrene 85-01-8 Not Assessed under the IRIS program.
461	Phenmedipham 13684-63-4 Not Assessed under the IRIS program.
462	Phenol 108-95-2 Not Assessed under the IRIS program.
463	m-Phenylenediamine 108-45-2 Not Assessed under the IRIS program.
464	Phenylmercuric acetate 62-38-4 Not Assessed under the IRIS program.
465	Phosalone 2310-17-0 Not Assessed under the IRIS program.
466	Phosgene 75-44-5 Not Assessed under the IRIS program.
467	Phosmet 732-11-6 Not Assessed under the IRIS program.
468	Phosphine 7803-51-2 Not Assessed under the IRIS program.
469	Phosphoric acid 7664-38-2 Not Assessed under the IRIS program.
470	Phthalic anhydride 85-44-9 Not Assessed under the IRIS program.
471	Picloram 1918-02-1 Not Assessed under the IRIS program.
472	Pirimiphos-methyl 29232-93-7 Not Assessed under the IRIS program.
473	Polychlorinated biphenyls (PCBs)	1336-36-3	Liver hepatocellular adenomas, carcinomas, cholangiomas, or cholangiocarcinomas	Linear extrapolation below LED10s	per µg /m3	1x10-4	Oral, Diet
474	Potassium cyanide 151-50-8 Not Assessed under the IRIS program.
475	Potassium silver cyanide 506-61-6 Not Assessed under the IRIS program.
476	Prochloraz 67747-09-5 Not Assessed under the IRIS program.
477	Prometon 1610-18-0 Not Assessed under the IRIS program.
478	Prometryn 7287-19-6 Not Assessed under the IRIS program.
479	Pronamide 23950-58-5 Not Assessed under the IRIS program.
480	Propachlor 1918-16-7 Not Assessed under the IRIS program.
481	Propanil 709-98-8 Not Assessed under the IRIS program.
482	Propargite 2312-35-8 Not Assessed under the IRIS program.
483	Propargyl alcohol 107-19-7 Not Assessed under the IRIS program.
484	Propazine 139-40-2 Not Assessed under the IRIS program.
485	Propham 122-42-9 Not Assessed under the IRIS program.
486	Propiconazole 60207-90-1 Not Assessed under the IRIS program.
487	beta-Propiolactone 57-57-8 Not Assessed under the IRIS program.
488	Propionaldehyde 123-38-6 Not Assessed under the IRIS program.
489	Propylene glycol 57-55-6 Not Assessed under the IRIS program.
490	Propylene glycol monoethyl ether 52125-53-8 Not Assessed under the IRIS program.
491	Propylene glycol monomethyl ether (PGME) 107-98-2 Not Assessed under the IRIS program.
492	Propylene oxide	75-56-9	Nasal cavity hemangioma or hemangiosarcoma	Linearized multistage procedure, extra risk	per µg /m3	3.7x10-6	Inhalation
493	Propyleneimine 75-55-8 Not Assessed under the IRIS program.
494	Pursuit 81335-77-5 Not Assessed under the IRIS program.
495	Pydrin 51630-58-1 Not Assessed under the IRIS program.
496	Pyrene 129-00-0 Not Assessed under the IRIS program.
497	Pyridine 110-86-1 Not Assessed under the IRIS program.
498	Quinalphos 13593-03-8 Not Assessed under the IRIS program.
499	Quinoline 91-22-5 Information reviewed but value not estimated. Refer to IRIS Summary.
500
501	Quinone 106-51-4 Not Assessed under the IRIS program.
502	Radium 226,228 7440-14-4 Not Assessed under the IRIS program.
503	Radon 222 14859-67-7 Not Assessed under the IRIS program.
504	Refractory ceramic fibers NA Information reviewed but value not estimated. Refer to IRIS Summary.
505
506	Resmethrin 10453-86-8 Not Assessed under the IRIS program.
507	Rotenone 83-79-4 Not Assessed under the IRIS program.
508	Savey 78587-05-0 Not Assessed under the IRIS program.
509	Selenious acid 7783-00-8 Not Assessed under the IRIS program.
510	Selenium and Compounds 7782-49-2 Not Assessed under the IRIS program.
511	Selenium sulfide 7446-34-6 Not Assessed under the IRIS program.
512	Selenourea 630-10-4 Not Assessed under the IRIS program.
513	Sethoxydim 74051-80-2 Not Assessed under the IRIS program.
514	Silver 7440-22-4 Not Assessed under the IRIS program.
515	Silver cyanide 506-64-9 Not Assessed under the IRIS program.
516	Simazine 122-34-9 Not Assessed under the IRIS program.
517	Sodium azide 26628-22-8 Not Assessed under the IRIS program.
518	Sodium cyanide 143-33-9 Not Assessed under the IRIS program.
519	Sodium diethyldithiocarbamate 148-18-5 Not Assessed under the IRIS program.
520	Sodium fluoroacetate 62-74-8 Not Assessed under the IRIS program.
521	Strontium 7440-24-6 Not Assessed under the IRIS program.
522	Strychnine 57-24-9 Not Assessed under the IRIS program.
523	Styrene 100-42-5 Not Assessed under the IRIS program.
524	Systhane 88671-89-0 Not Assessed under the IRIS program.
525	Tebuthiuron 34014-18-1 Not Assessed under the IRIS program.
526	Terbacil 5902-51-2 Not Assessed under the IRIS program.
527	Terbutryn 886-50-0 Not Assessed under the IRIS program.
528	Tetrabromodiphenyl ether 40088-47-9 Not Assessed under the IRIS program.
529	2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) 5436-43-1 Not Assessed under the IRIS program.
530	1,2,4,5-Tetrachlorobenzene 95-94-3 Not Assessed under the IRIS program.
531	Tetrachlorocyclopentadiene 695-77-2 Not Assessed under the IRIS program.
532	1,1,1,2-Tetrachloroethane	630-20-6	Hepatocellular adenoma or carcinoma	Linearized multistage procedure, extra risk	per µg /m3	7.4x10-6	Oral, Gavage
533	1,1,2,2-Tetrachloroethane 79-34-5 Information reviewed but value not estimated. Refer to IRIS Summary.
534	Tetrachloroethylene 127-18-4 Not Assessed under the IRIS program.
535	2,3,4,6-Tetrachlorophenol 58-90-2 Not Assessed under the IRIS program.
536	Tetrachlorovinphos 961-11-5 Not Assessed under the IRIS program.
537	Tetraethyl lead 78-00-2 Not Assessed under the IRIS program.
538	Tetraethyldithiopyrophosphate 3689-24-5 Not Assessed under the IRIS program.
539	1,1,1,2-Tetrafluoroethane 811-97-2 Not Assessed under the IRIS program.
540	Thallium (I), soluble salts Various Not Assessed under the IRIS program.
541	Thallium acetate 563-68-8 Not Assessed under the IRIS program.
542	Thallium carbonate 6533-73-9 Not Assessed under the IRIS program.
543	Thallium chloride 7791-12-0 Not Assessed under the IRIS program.
544	Thallium nitrate 10102-45-1 Not Assessed under the IRIS program.
545	Thallium oxide 1314-32-5 Not Assessed under the IRIS program.
546	Thallium selenite 12039-52-0 Not Assessed under the IRIS program.
547	Thallium(I) sulfate 7446-18-6 Not Assessed under the IRIS program.
548	Thiobencarb 28249-77-6 Not Assessed under the IRIS program.
549	Thiophanate-methyl 23564-05-8 Not Assessed under the IRIS program.
550	Thiram 137-26-8 Not Assessed under the IRIS program.
551	Toluene 108-88-3 Not Assessed under the IRIS program.
552	2,4-/2,6-Toluene diisocyanate mixture (TDI)	26471-62-5	Not Assessed under the IRIS program.
553	Toxaphene	8001-35-2	Hepatocellular carcinomas and neoplastic nodules	Linearized multistage procedure, extra risk	per µg /m3	3.2x10-4	Oral, Diet
554	Tralomethrin	66841-25-6	Not Assessed under the IRIS program.
555	Triallate	2303-17-5	Not Assessed under the IRIS program.
556	Triasulfuron	82097-50-5	Not Assessed under the IRIS program.
557	1,2,4-Tribromobenzene	615-54-3	Not Assessed under the IRIS program.
558	Tribromochloromethane	594-15-0	Not Assessed under the IRIS program.
559	Tribromodiphenyl ether	49690-94-0	Not Assessed under the IRIS program.
560	Tributyltin oxide (TBTO)	56-35-9	Not Assessed under the IRIS program.
561	1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113)	76-13-1	Not Assessed under the IRIS program.
562	Trichloroacetic acid	76-03-9	Information reviewed but value not estimated. Refer to IRIS Summary.
563	1,2,4-Trichlorobenzene	120-82-1	Not Assessed under the IRIS program.
564	Trichlorocyclopentadiene	77323-84-3	Not Assessed under the IRIS program.
565	1,1,2-Trichloroethane	79-00-5	Hepatocellular carcinoma	Linearized multistage procedure, extra risk	per µg /m3	1.6x10-5	Oral, Gavage
566	1,1,1-Trichloroethane	71-55-6	Information reviewed but value not estimated. Refer to IRIS Summary.
567	Trichloroethylene	79-01-6	Renal cell carcinoma, non-Hodgkin's lymphoma, and liver tumors	Low-dose linear extrapolation from the point of departure (LEC01) with a factor of 4 applied to include non-Hodgkin's lymphoma (NHL) and liver cancer risks, combined risk	per µg /m3	4.1x10-6	Inhalation
568	Trichlorofluoromethane	75-69-4	Not Assessed under the IRIS program.
569	2,4,5-Trichlorophenol	95-95-4	Not Assessed under the IRIS program.
570	2,4,6-Trichlorophenol	88-06-2	Leukemia	Linearized multistage procedure, extra risk	per µg /m3	3.1x10-6	Oral,Diet
571	2(2,4,5-Trichlorophenoxy) propionic acid (2,4,5-TP)	93-72-1	Not Assessed under the IRIS program.
572	2,4,5-Trichlorophenoxyacetic acid (2,4,5-T)	93-76-5	Not Assessed under the IRIS program.
573	1,1,2-Trichloropropane	598-77-6	Not Assessed under the IRIS program.
574	1,2,3-Trichloropropane	96-18-4	Not Assessed under the IRIS program.
575	Tricresol	1319-77-3	Not Assessed under the IRIS program.
576	Tridiphane	58138-08-2	Not Assessed under the IRIS program.
577	Triethylamine	121-44-8	Not Assessed under the IRIS program.
578	Triethylene glycol monobutyl ether	143-22-6	Not Assessed under the IRIS program.
579	Triethylene glycol monoethyl ether	112-50-5	Not Assessed under the IRIS program.
580	Trifluralin	1582-09-8	Not Assessed under the IRIS program.
581	2,2,4-Trimethylpentane	540-84-1	Not Assessed under the IRIS program.
582	1,3,5-Trinitrobenzene	99-35-4	Not Assessed under the IRIS program.
583	2,4,6-Trinitrotoluene (TNT)	118-96-7	Not Assessed under the IRIS program.
584	Uranium, natural	7440-61-1	Not Assessed under the IRIS program.
585	Uranium, soluble salts	NA	Not Assessed under the IRIS program.
586	Urea	57-13-6	Not Assessed under the IRIS program.
587	Vanadium pentoxide	1314-62-1	Not Assessed under the IRIS program.
588	Vernam	1929-77-7	Not Assessed under the IRIS program.
589	Vinclozolin	50471-44-8	Not Assessed under the IRIS program.
590	Vinyl acetate	108-05-4	Not Assessed under the IRIS program.
591	Vinyl bromide	593-60-2Not Assessed under the IRIS program.
592	Vinyl chloride	75-01-4	Liver angiosarcomas, angiomas, hepatomas, and neoplastic nodules	LMS method	per µg /m3	4.4x10-6	Inhalation
593	Vinyl chloride	75-01-4	Liver angiosarcomas, angiomas, hepatomas, and neoplastic nodules	LED 10/ linear method	per µg /m3	4.4x10-6	Inhalation
594	Vinyl chloride	75-01-4	Liver angiosarcomas, angiomas, hepatomas, and neoplastic nodules	LMS method	per µg /m3	8.8x10-6	Inhalation
595	Vinyl chloride	75-01-4	Liver angiosarcomas, angiomas, hepatomas, and neoplastic nodules	LED 10/ linear method	per µg /m3	8.8x10-6	Inhalation
596	Warfarin	81-81-2	Not Assessed under the IRIS program.
597	White phosphorus	7723-14-0	Not Assessed under the IRIS program.
598	Xylenes	1330-20-7	Not Assessed under the IRIS program.
599	Zinc and Compounds	7440-66-6	Not Assessed under the IRIS program.
600	Zinc cyanide	557-21-1	Not Assessed under the IRIS program.
601	Zinc phosphide	1314-84-7	Not Assessed under the IRIS program.
602	Zineb	12122-67-7	Not Assessed under the IRIS program.

Related files

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