Difference between revisions of "AH receptor"
(New page: {{encyclopedia|moderator=Henrik}} AH receptor (AHR, dioxin receptor, aryl hydrocarbon receptor), a cell protein that initiates many of the effects of dioxin-like chemicals. Its primary f...) |
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AH receptor (AHR, dioxin receptor, aryl hydrocarbon receptor), a cell protein that initiates many of the effects of dioxin-like chemicals. Its primary function in the body is uncertain, and it is structurally related to many other important cell proteins involved for instance in rhythmic functions (clock proteins) and organ development. Mechanism. When TCDD or other dioxins enter the cell, they bind to AHR, this moves from cellular cytoplasm to nucleus, forms a pair with another protein ARNT (see this), and this heterodimer (complex of two separate proteins) binds to DNA (see this). This binding initiates the activation of a number of genes depending on the binding site of the dimer. Because it initiates the reading of a gene (transcription), it is called a transcription factor (see this). One of the best studied of such genes is the gene of CYP1A1 enzyme, which is a xenobiotic metabolising enzyme. CYP1A1 oxidises many foreign chemicals and makes them more water-soluble. Activation of its gene increases the enzymatic activity even by a factor of several hundreds. It is not known which gene is (genes are) responsible for the toxic effects of dioxins (for more information on AHR, see Okey et al., Toxicol. Lett. 1994:70:1-22). | AH receptor (AHR, dioxin receptor, aryl hydrocarbon receptor), a cell protein that initiates many of the effects of dioxin-like chemicals. Its primary function in the body is uncertain, and it is structurally related to many other important cell proteins involved for instance in rhythmic functions (clock proteins) and organ development. Mechanism. When TCDD or other dioxins enter the cell, they bind to AHR, this moves from cellular cytoplasm to nucleus, forms a pair with another protein ARNT (see this), and this heterodimer (complex of two separate proteins) binds to DNA (see this). This binding initiates the activation of a number of genes depending on the binding site of the dimer. Because it initiates the reading of a gene (transcription), it is called a transcription factor (see this). One of the best studied of such genes is the gene of CYP1A1 enzyme, which is a xenobiotic metabolising enzyme. CYP1A1 oxidises many foreign chemicals and makes them more water-soluble. Activation of its gene increases the enzymatic activity even by a factor of several hundreds. It is not known which gene is (genes are) responsible for the toxic effects of dioxins (for more information on AHR, see Okey et al., Toxicol. Lett. 1994:70:1-22). | ||
| + | [[category:Dioxin synopsis]] | ||
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AH receptor (AHR, dioxin receptor, aryl hydrocarbon receptor), a cell protein that initiates many of the effects of dioxin-like chemicals. Its primary function in the body is uncertain, and it is structurally related to many other important cell proteins involved for instance in rhythmic functions (clock proteins) and organ development. Mechanism. When TCDD or other dioxins enter the cell, they bind to AHR, this moves from cellular cytoplasm to nucleus, forms a pair with another protein ARNT (see this), and this heterodimer (complex of two separate proteins) binds to DNA (see this). This binding initiates the activation of a number of genes depending on the binding site of the dimer. Because it initiates the reading of a gene (transcription), it is called a transcription factor (see this). One of the best studied of such genes is the gene of CYP1A1 enzyme, which is a xenobiotic metabolising enzyme. CYP1A1 oxidises many foreign chemicals and makes them more water-soluble. Activation of its gene increases the enzymatic activity even by a factor of several hundreds. It is not known which gene is (genes are) responsible for the toxic effects of dioxins (for more information on AHR, see Okey et al., Toxicol. Lett. 1994:70:1-22).
