Beneris deliverables
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Project objectives
The general objective of this proposal is to create a framework for handling complicated benefit-risk situations, and apply it for analysis of the benefits and risks of certain foods. The first food commodity to be used in the development of the methodology is fish.
Objectives in developing benefit-risk analysis methods
- To develop Bayesian belief networks (BBN) to handle complicated benefit-risk situations, and to develop a decision support system (DSS) based on BBN.
- To develop improved methods for dose-response assessment, combining epidemiological and toxicological data, and apply them in combining epidemiological and toxicological information on fish contaminants (esp. dioxins and PCBs).
- To develop an integrated repository of surveillance, nutrient and food consumption data that is capable of receiving, analyzing, and disseminating the accumulated data for benefit-risk analysis and to key stakeholders.
Scientific objectives in food risks and benefits
- To review the existing databases and their availability for chemical contaminant data in Europe, and integrate available data.
- To estimate average nutrient intakes and food consumption in various subgroups based on national registries in three countries and to explore the use of the data in benefit-risk analysis.
- To estimate the health benefits of fish, and understand the effect of fish on different population subgroups (age, health, pregnancy etc.)
- To establish the association between external dose (intake) and internal dose (concentrations in the body) by analysing contaminants (PCDD/Fs, PCBs, PBDEs, organotin compounds, PCNs and Hg/methyl-Hg) from 100-200 placentas.
- To combine existing and new data from food consumption databases with data on levels of contaminants in fish. The special emphasis is on children and the developing foetus.
- To estimate distributions of nutrient intake and food consumption relevant to benefit-risk analysis in a number of populations, and also the variability in exposure among various subgroups in the population.
- To identify food consumption patterns and food choices that determine the intake of those nutrients and contaminants that are related to benefit/risk-balance of a food item.
- To explore the usability of these patterns in another country than in which they were developed.
- To find out the effects of certain policy options on dietary habits and on intake of important nutrients and contaminants (e.g. vitamin D, n-3 fatty acids, dioxins, PCBs). As an example, does a restrictive recommendation on fish eating increase meat consumption?
Objectives in dissemination
- To integrate results into updated benefit-risk assessments, and evaluate the remaining uncertainties and their importance for decision-making.
- To evaluate the integration methodology by all partners and develop it further.
- To develop an internet interface for publishing risk assessment results.
- To develop a method to publish entire benefit-risk models over the Internet using XML.
- To develop methods to collect feedback from end-users about benefit-risk analyses.
- To enhance the availability of existing databases through this interface.
- To disseminate the results and to evaluate the relevance and usefulness of the work done in the project from the perspective of an end-user / authority.
