Difference between revisions of "Dioxin concentrations during a lifetime of an average Finn"

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(new intake estimates and new results)
Line 5: Line 5:
  
 
=== Data ===  
 
=== Data ===  
−
List of data files or sources:
 
  
−
The data is based on author judgement
+
The adult intake is based on a food basket study<ref>Kiviranta et al (reports from Elintarvikevirasto, ca. 2004)</ref>. The peak exposure during the first year is an author judgement. It could be estimated more precisely by calculating the intake based on the fact that an active breast feeding can transfer ca. 25 % of the mother's body burden to the child<ref>Vartiainen et al, ca. 1996)</ref>:
−
* Start of pic (days) 100
+
* Intake at age 0 - 5 a (ng/min) 0.000173611
−
* End of pic (days) 20000
+
* Intake at age 5 - 10 a (ng/min) 0.000173611
−
* Dose of pic (ng/min) 0.0000069
+
* Intake at age 10 -15 a (ng/min) 0.000173611
−
* Dose of base 1 (ng/min) 0.0000069
+
* Intake at age 15 -40 a (ng/min) 0.000173611
−
* Dose of base 2 (ng/min) 0.0000069
+
* Intake at age 40 - a (ng/min) 0.000173611
−
* Dose of base 3 (ng/min) 0.0000069
+
* Start of peak exposure (days) 10
−
* Dose of base 4 (ng/min) 0.0000069
+
* End of peak exposure (days) 365
−
* Dose of base 5 (ng/min) 0.0000069
+
* Dose of pic (ng/min) 0.0005
  
 
=== Causality ===  
 
=== Causality ===  
Line 24: Line 23:
  
 
{{Dioxin PBPK model
 
{{Dioxin PBPK model
−
|peakstart=100
+
|peakstart=10
−
|peakend=20000
+
|peakend=365
−
|peakdose=0.0000069
+
|peakdose=0.0005
−
|dose1=0.0000069
+
|dose1=0.000173611
−
|dose2=0.0000069
+
|dose2=0.000173611
−
|dose3=0.0000069
+
|dose3=0.000173611
−
|dose4=0.0000069
+
|dose4=0.000173611
−
|dose5=0.0000069
+
|dose5=0.000173611
 
}}
 
}}
  
 
=== Unit ===  
 
=== Unit ===  
  
−
ng/kg fat (blood) or ng (other organs)
+
ng/l (concentration, in blood) or ng (total amount, in other organs)
  
 
== Result ==
 
== Result ==
  
 
For the full result, run the model again.
 
For the full result, run the model again.
 +
 +
{{comment|#1: |The concentrations are higher (ca. double) than what is measured from the Finnish population, although the intake is close to the current intake estimates. Maybe the model assumes too long half-life for dioxin.|--[[User:Jouni|Jouni]] 22:32, 4 January 2008 (EET)}}
  
 
{| {{prettytable}}
 
{| {{prettytable}}
−
!time (min)
+
!age (years)
−
!Concentration in blood
+
!Concentration in blood (ng/l)
−
!Quantity in fat
+
!Quantity in fat (ng)
−
!Quantity in visceral organs
+
!Quantity in visceral organs (ng)
−
!Quantity in muscle and skin
+
!Quantity in muscle and skin (ng)
−
!Quantity in liver
+
!Quantity in liver (ng)
 
|-----
 
|-----
−
|10,000
+
|0
−
|0,000
+
|3.01E-005
−
|0,000
+
|6.74E-005
−
|0,000  
+
|0
−
|0,000  
+
|0
−
|0,000
+
|0
 
|----
 
|----
−
|1 000 010,000
+
|1.9
−
|0,027
+
|0.89
−
|10,863
+
|363.88
−
|0,781
+
|26.13
−
|0,750
+
|25.11
−
|0,395
+
|13.21
 
|----
 
|----
−
|2 000 010,000
+
|3.81
−
|0,035
+
|0.8
−
|23,469
+
|531.22
−
|1,206
+
|27.29
−
|1,272
+
|28.78
−
|0,598
+
|13.54
 
|----
 
|----
−
|3 000 010,000
+
|5.71
−
|0,039
+
|0.75
−
|36,141
+
|693.68
−
|1,550
+
|29.74
−
|1,837
+
|35.26
−
|0,760
+
|14.57
 
|----
 
|----
−
|4 000 010,000
+
|7.61
−
|0,041
+
|0.72
−
|48,702
+
|852.55
−
|1,863
+
|32.61
−
|2,538
+
|44.42
−
|0,913
+
|15.98
 
|----
 
|----
−
|5 000 010,000
+
|9.51
−
|0,043
+
|0.7
−
|61,103
+
|1008.36
−
|2,141
+
|35.33
−
|3,419
+
|56.42
−
|1,070
+
|17.65
 
|----
 
|----
−
|6 000 010,000
+
|11.42
−
|0,035
+
|0.55
−
|75,254
+
|1191.91
−
|1,882
+
|29.8
−
|3,328
+
|52.71
−
|0,980
+
|15.52
 
|----
 
|----
−
|7 000 010,000
+
|13.32
−
|0,029
+
|0.44
−
|89,400
+
|1373.74
−
|1,660
+
|25.51
−
|3,186
+
|48.95
−
|0,919
+
|14.11
 
|----
 
|----
−
|8 000 010,000
+
|15.22
−
|0,026
+
|0.4
−
|103,273
+
|1550.47
−
|1,559
+
|23.4
−
|3,133
+
|47.03
−
|0,923
+
|13.86
 
|----
 
|----
−
|9 000 010,000
+
|17.12
−
|0,028
+
|0.42
−
|116,203
+
|1712.79
−
|1,705
+
|25.12
−
|3,620
+
|53.36
−
|1,075
+
|15.84
 
|----
 
|----
−
|10 000 000,000
+
|19.03
−
|0,030
+
|0.44
−
|129,311
+
|1877.73
−
|1,833
+
|26.61
−
|3,948
+
|57.33
−
|1,215
+
|17.64
 
|----
 
|----
−
|11 000 000,000
+
|20.93
−
|0,032
+
|0.46
−
|142,528
+
|2044.22
−
|1,947
+
|27.93
−
|4,188
+
|60.05
−
|1,336
+
|19.16
 
|----
 
|----
−
|12 000 000,000
+
|22.83
−
|0,034
+
|0.48
−
|155,811
+
|2211.6
−
|2,051
+
|29.11
−
|4,381
+
|62.18
−
|1,438
+
|20.41
 
|----
 
|----
−
|13 000 000,000
+
|24.73
−
|0,035
+
|0.5
−
|169,138
+
|2379.53
−
|2,147
+
|30.2
−
|4,548
+
|63.98
−
|1,524
+
|21.44
 
|----
 
|----
−
|14 000 000,000
+
|26.64
−
|0,037
+
|0.51
−
|182,495
+
|2547.83
−
|2,235
+
|31.2
−
|4,696
+
|65.56
−
|1,598
+
|22.31
 
|----
 
|----
−
|15 000 000,000
+
|28.54
−
|0,038
+
|0.53
−
|195,877
+
|2716.43
−
|2,317
+
|32.13
−
|4,829
+
|66.96
−
|1,664
+
|23.07
 
|----
 
|----
−
|16 000 000,000
+
|30.44
−
|0,039
+
|0.54
−
|209,279
+
|2885.26
−
|2,394
+
|33
−
|4,948
+
|68.22
−
|1,722
+
|23.74
 
|----
 
|----
−
|17 000 000,000
+
|32.34
−
|0,040
+
|0.55
−
|222,698
+
|3054.29
−
|2,466
+
|33.82
−
|5,056
+
|69.33
−
|1,776
+
|24.36
 
|----
 
|----
−
|18 000 000,000
+
|34.25
−
|0,042
+
|0.57
−
|236,132
+
|3223.5
−
|2,534
+
|34.58
−
|5,152
+
|70.33
−
|1,826
+
|24.93
 
|----
 
|----
−
|19 000 000,000
+
|36.15
−
|0,043
+
|0.58
−
|249,579
+
|3392.85
−
|2,597
+
|35.31
−
|5,238
+
|71.21
−
|1,873
+
|25.45
 
|----
 
|----
−
|20 000 000,000
+
|38.05
−
|0,044
+
|0.59
−
|263,038
+
|3562.34
−
|2,657
+
|35.99
−
|5,315
+
|71.98
−
|1,916
+
|25.95
 
|----
 
|----
−
|21 000 000,000
+
|39.95
−
|0,045
+
|0.6
−
|276,508
+
|3731.95
−
|2,714
+
|36.63
−
|5,384
+
|72.66
−
|1,957
+
|26.42
 
|----
 
|----
−
|22 000 000,000
+
|41.86
−
|0,045
+
|0.61
−
|289,988
+
|3901.67
−
|2,768
+
|37.24
−
|5,444
+
|73.25
−
|1,996
+
|26.86
 
|----
 
|----
−
|23 000 000,000
+
|43.76
−
|0,046
+
|0.62
−
|303,477
+
|4071.5
−
|2,819
+
|37.81
−
|5,498
+
|73.75
−
|2,033
+
|27.27
 
|----
 
|----
−
|24 000 000,000
+
|45.66
−
|0,047
+
|0.63
−
|316,974
+
|4241.41
−
|2,867
+
|38.36
−
|5,544
+
|74.18
−
|2,068
+
|27.67
 
|----
 
|----
−
|25 000 000,000
+
|47.56
−
|0,048
+
|0.64
−
|330,478
+
|4411.42
−
|2,913
+
|38.88
−
|5,585
+
|74.55
−
|2,101
+
|28.04
 
|----
 
|----
−
|26 000 000,000
+
|49.47
−
|0,049
+
|0.65
−
|343,989
+
|4581.49
−
|2,956
+
|39.38
−
|5,619
+
|74.84
−
|2,132
+
|28.4
 
|----
 
|----
−
|27 000 000,000
+
|51.37
−
|0,049
+
|0.65
−
|357,507
+
|4751.64
−
|2,998
+
|39.85
−
|5,649
+
|75.08
−
|2,162
+
|28.74
 
|----
 
|----
−
|28 000 000,000
+
|53.27
−
|0,050
+
|0.66
−
|371,030
+
|4921.86
−
|3,038
+
|40.3
−
|5,673
+
|75.26
−
|2,191
+
|29.06
 
|----
 
|----
−
|29 000 000,000
+
|55.18
−
|0,050
+
|0.67
−
|383,221
+
|5092.14
−
|3,064
+
|40.73
−
|5,672
+
|75.38
−
|2,210
+
|29.37
 
|----
 
|----
−
|30 000 000,000
+
|57.08
−
|0,050
+
|0.67
−
|390,042
+
|5262.47
−
|3,048
+
|41.14
−
|5,591
+
|75.46
−
|2,198
+
|29.67
 
|----
 
|----
−
|31 000 000,000
+
|58.98
−
|0,050
+
|0.68
−
|396,861
+
|5432.85
−
|3,033
+
|41.53
−
|5,513
+
|75.49
−
|2,187
+
|29.95
 
|----
 
|----
−
|32 000 000,000
+
|60.88
−
|0,050
+
|0.69
−
|403,679
+
|5603.29
−
|3,018
+
|41.9
−
|5,436
+
|75.48
−
|2,177
+
|30.22
 
|----
 
|----
−
|33 000 000,000
+
|62.79
−
|0,049
+
|0.69
−
|410,495
+
|5773.76
−
|3,004
+
|42.26
−
|5,361
+
|75.43
−
|2,166
+
|30.48
 
|----
 
|----
−
|34 000 000,000
+
|64.69
−
|0,049
+
|0.7
−
|417,309
+
|5944.28
−
|2,991
+
|42.61
−
|5,288
+
|75.34
−
|2,157
+
|30.73
 
|----
 
|----
−
|35 000 000,000
+
|66.59
−
|0,049
+
|0.7
−
|424,121
+
|6114.84
−
|2,978
+
|42.94
−
|5,216
+
|75.21
−
|2,147
+
|30.97
 
|----
 
|----
−
|36 000 000,000
+
|68.49
−
|0,049
+
|0.71
−
|430,933
+
|6285.44
−
|2,965
+
|43.26
−
|5,145
+
|75.06
−
|2,139
+
|31.2
 
|----
 
|----
 
|}
 
|}
 +
 +
==References==
 +
 +
<references/>

Revision as of 20:32, 4 January 2008

Scope

Dioxin concentrations during a lifetime of an average Finn describes the development of dioxin concentrations in several tissues in an average Finnish woman exposed to current (2008) levels.

Definition

Data

The adult intake is based on a food basket study[1]. The peak exposure during the first year is an author judgement. It could be estimated more precisely by calculating the intake based on the fact that an active breast feeding can transfer ca. 25 % of the mother's body burden to the child[2]:

  • Intake at age 0 - 5 a (ng/min) 0.000173611
  • Intake at age 5 - 10 a (ng/min) 0.000173611
  • Intake at age 10 -15 a (ng/min) 0.000173611
  • Intake at age 15 -40 a (ng/min) 0.000173611
  • Intake at age 40 - a (ng/min) 0.000173611
  • Start of peak exposure (days) 10
  • End of peak exposure (days) 365
  • Dose of pic (ng/min) 0.0005

Causality

List of parents:

  • None

Formula

Dioxin PBPK model
The results are total amounts (ng) of dioxin, except blood concentration (ng/l).

See the model documentation

The input data used for this variable:
  • Intake at age 0 - 5 a (ng/min) 0.000173611
  • Intake at age 5 - 10 a (ng/min) 0.000173611
  • Intake at age 10-15 a (ng/min) 0.000173611
  • Intake at age 15 - 40 a (ng/min) 0.000173611
  • Intake at age 40 - a (ng/min) 0.000173611
  • Start of peak intake (days) 10
  • End of peak intake (days) 365
  • Additional peak intake (ng/min) 0.0005

Click here to run the model

Unit

ng/l (concentration, in blood) or ng (total amount, in other organs)

Result

For the full result, run the model again.

--#1: : The concentrations are higher (ca. double) than what is measured from the Finnish population, although the intake is close to the current intake estimates. Maybe the model assumes too long half-life for dioxin. --Jouni 22:32, 4 January 2008 (EET)

age (years) Concentration in blood (ng/l) Quantity in fat (ng) Quantity in visceral organs (ng) Quantity in muscle and skin (ng) Quantity in liver (ng)
0 3.01E-005 6.74E-005 0 0 0
1.9 0.89 363.88 26.13 25.11 13.21
3.81 0.8 531.22 27.29 28.78 13.54
5.71 0.75 693.68 29.74 35.26 14.57
7.61 0.72 852.55 32.61 44.42 15.98
9.51 0.7 1008.36 35.33 56.42 17.65
11.42 0.55 1191.91 29.8 52.71 15.52
13.32 0.44 1373.74 25.51 48.95 14.11
15.22 0.4 1550.47 23.4 47.03 13.86
17.12 0.42 1712.79 25.12 53.36 15.84
19.03 0.44 1877.73 26.61 57.33 17.64
20.93 0.46 2044.22 27.93 60.05 19.16
22.83 0.48 2211.6 29.11 62.18 20.41
24.73 0.5 2379.53 30.2 63.98 21.44
26.64 0.51 2547.83 31.2 65.56 22.31
28.54 0.53 2716.43 32.13 66.96 23.07
30.44 0.54 2885.26 33 68.22 23.74
32.34 0.55 3054.29 33.82 69.33 24.36
34.25 0.57 3223.5 34.58 70.33 24.93
36.15 0.58 3392.85 35.31 71.21 25.45
38.05 0.59 3562.34 35.99 71.98 25.95
39.95 0.6 3731.95 36.63 72.66 26.42
41.86 0.61 3901.67 37.24 73.25 26.86
43.76 0.62 4071.5 37.81 73.75 27.27
45.66 0.63 4241.41 38.36 74.18 27.67
47.56 0.64 4411.42 38.88 74.55 28.04
49.47 0.65 4581.49 39.38 74.84 28.4
51.37 0.65 4751.64 39.85 75.08 28.74
53.27 0.66 4921.86 40.3 75.26 29.06
55.18 0.67 5092.14 40.73 75.38 29.37
57.08 0.67 5262.47 41.14 75.46 29.67
58.98 0.68 5432.85 41.53 75.49 29.95
60.88 0.69 5603.29 41.9 75.48 30.22
62.79 0.69 5773.76 42.26 75.43 30.48
64.69 0.7 5944.28 42.61 75.34 30.73
66.59 0.7 6114.84 42.94 75.21 30.97
68.49 0.71 6285.44 43.26 75.06 31.2

References

  1. ↑ Kiviranta et al (reports from Elintarvikevirasto, ca. 2004)
  2. ↑ Vartiainen et al, ca. 1996)
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