Difference between revisions of "Dose-response function of cardiovascular effects of omega-3 fatty acids"
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'''Dose-response function of cardiovascular effects of omega-3 fatty acids''' describes the exposure-response function where also the uncertainty about the population that benefits from omega-3 is taken into account. | '''Dose-response function of cardiovascular effects of omega-3 fatty acids''' describes the exposure-response function where also the uncertainty about the population that benefits from omega-3 is taken into account. | ||
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| + | ==Rationale== | ||
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| + | ===Data=== | ||
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| + | Dose-response function comes from secondary prevention trials reviewed by Din 2004 Table 1. The relative risk reductions are divided by the omega3 exposure in each study. A continuous distribution is used, and each study result is used as a quintile point for the distribution. Another review is Marckmann and Gronbaek 1999 that concluded that 0.6-0.9 g/d of omega-3 results in 40-60 % decrease in coronary heart disease mortality. The low estimate from this result was used (40% per 0.9 g/d). | ||
| + | <ref>Din JN, Newby DE, Flapan AD. Science, medicine, and the future - Omega 3 fatty acids and cardiovascular disease - fishing for a natural treatment. British Medical Journal 2004; 328(7430):30-35. [http://ytoswww/yhteiset/Huippuyksikko/Kirjallisuus/Fish_and_health/Din_Omega3andCVD_BMJ2004.pdf Intranet file]</ref> | ||
| + | <ref>Marckmann P, Gronbaek M. Fish consumption and coronary heart disease mortality. A systematic review of prospective cohort studies. European Journal of Clinical Nutrition 1999; 53(8):585-590.</ref> | ||
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| + | A large part of omega-3 benefit literature is based on studies on cardiac patients. This node reflects the uncertainty whether there is cardiac health benefit for everyone or only coronary heart disease (CHD) patients. The estimate is not based on data but the aim is to maximise uncertainty. | ||
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| + | ===Causality=== | ||
| + | |||
| + | Upstream variables | ||
| + | * None | ||
| + | |||
| + | ===Unit=== | ||
| + | |||
| + | probability change/(g/d) | ||
| + | |||
| + | ===Formula=== | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Latest revision as of 08:12, 13 October 2012
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Question
Dose-response function of cardiovascular effects of omega-3 fatty acids describes the exposure-response function where also the uncertainty about the population that benefits from omega-3 is taken into account.
Answer
| Statistics or fractile | |
| Mean | -0.186 |
| SD | 0.116 |
| 0.01 | -0.437 |
| 0.025 | -0.425 |
| 0.05 | -0.406 |
| 0.25 | -0.269 |
| 0.5 (Median) | -0.154 |
| 0.75 | -0.099 |
| 0.95 | -0.025 |
| 0.975 | -0.013 |
| 0.99 | -0.005 |
Rationale
Data
Dose-response function comes from secondary prevention trials reviewed by Din 2004 Table 1. The relative risk reductions are divided by the omega3 exposure in each study. A continuous distribution is used, and each study result is used as a quintile point for the distribution. Another review is Marckmann and Gronbaek 1999 that concluded that 0.6-0.9 g/d of omega-3 results in 40-60 % decrease in coronary heart disease mortality. The low estimate from this result was used (40% per 0.9 g/d). [1] [2]
A large part of omega-3 benefit literature is based on studies on cardiac patients. This node reflects the uncertainty whether there is cardiac health benefit for everyone or only coronary heart disease (CHD) patients. The estimate is not based on data but the aim is to maximise uncertainty.
Causality
Upstream variables
- None
Unit
probability change/(g/d)
Formula
References
- ↑ Din JN, Newby DE, Flapan AD. Science, medicine, and the future - Omega 3 fatty acids and cardiovascular disease - fishing for a natural treatment. British Medical Journal 2004; 328(7430):30-35. Intranet file
- ↑ Marckmann P, Gronbaek M. Fish consumption and coronary heart disease mortality. A systematic review of prospective cohort studies. European Journal of Clinical Nutrition 1999; 53(8):585-590.
