Difference between revisions of "Dose-response function of persistent pollutants"

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==Scope==
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==Question==
  
 
'''Dose-response function of persistent pollutants''' describes the cancer dose-responses of several pollutants in humans (lifetime risk due to lifetime exposure).  
 
'''Dose-response function of persistent pollutants''' describes the cancer dose-responses of several pollutants in humans (lifetime risk due to lifetime exposure).  
  
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==Definition==
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==Answer==
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{{resultlink}}
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{| {{prettytable}}
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|
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|Dose-response slope
 +
|-----
 +
|Dieldrin
 +
|16
 +
|----
 +
|Toxaphene
 +
|1.1
 +
|----
 +
|Dioxin
 +
|1.56E+005
 +
|----
 +
|PCB
 +
|2
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|----
 +
|}
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==Rationale==
  
 
===Data===
 
===Data===
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CSFs are directly used.
 
CSFs are directly used.
  
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==Result==
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==See also==
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{{resultlink}}
 
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{| {{prettytable}}
 
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|
 
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|Dose-response slope
 
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|-----
 
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|Dieldrin
 
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|16
 
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|----
 
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|Toxaphene
 
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|1.1
 
−
|----
 
−
|Dioxin
 
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|1.56E+005
 
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|----
 
−
|PCB
 
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|2
 
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|----
 
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|}
 
  
  

Latest revision as of 08:13, 13 October 2012

Benefit-risk assessment on farmed salmon: To the assessment page | To the Analytica model
Decision variables:

Variable:Recommendation for consumption of farmed salmon | Variable:Pollutant concentration limits for fish feed

Indicators:

Variable:Pollutant health risk due to the consumption of salmon | Variable:Net health effects due to the consumption of salmon

Other variables:

Variable:Persistent pollutant concentrations in fish feed | Variable:Persistent pollutant concentrations in salmon | Variable:Salmon intake in the population of the Western Europe | Variable:Exposure to persistent pollutants due to salmon in the population of the Western Europe | Variable:Dose-response function of persistent pollutants | Variable:Omega-3 content in salmon | Variable:Omega-3 intake due to salmon in the population of the Western Europe | Variable:Dose-response function of cardiovascular effects of omega-3 fatty acids | Variable:Total mortality in the Western Europe | Variable:Cardiovascular mortality in the Western Europe | Variable:Cardiovascular effects of omega-3 in salmon in the Western Europe


Question

Dose-response function of persistent pollutants describes the cancer dose-responses of several pollutants in humans (lifetime risk due to lifetime exposure).

Answer

Show results


Dose-response slope
Dieldrin 16
Toxaphene 1.1
Dioxin 1.56E+005
PCB 2

Rationale

Data

Potency of pollutants. Cancer slope factors (CSF) are used for cancer and Reference Dose (RfD) values are used for non-cancer endpoints. The data comes from the U.S.EPA. [1]

The response assessment is restricted to cancer endpoints, because it is the more sensitive endpoint.

Table. Cancer slope factors (CSF) for several pollutants.

CSF
Dieldrin 16
Toxaphene 1.1
Dioxin 1.56E+005
PCB 2

Causality

Upstream variables

  • None

Unit

(mg/kg/d)-1

Formula

CSFs are directly used.

See also

References

  1. ↑ U.S.EPA. Guidance for Assessing Chemical Contaminant Data for Use in Fish Advisory. Volume 2: Risk Assessment and Fish Consumption Limits, 3rd Edition. 2000. Table 3-1. Open access Internet file Intranet file
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