Difference between revisions of "ERF of dioxin"
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<t2b index="Disease,Response metric,Exposure route,Exposure metric,Exposure unit,Threshold,ERF parameter,Observation" locations="ERF,Description" unit=""> | <t2b index="Disease,Response metric,Exposure route,Exposure metric,Exposure unit,Threshold,ERF parameter,Observation" locations="ERF,Description" unit=""> | ||
| − | Cancer|Lifetime probability of developing cancer| | + | Cancer|Lifetime probability of developing cancer|Ingestion|Intake|(mg/kg bw/d)^-1||Oral CSF|156000|US EPA |
</t2b> | </t2b> | ||
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Question
ERF of dioxin on cancer describes the quantitative relationship between exposure to polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) and remaining lifetime cancer risk in adult Beneris population.
Answer
You have error(s) in your data:You must define units. Please use syntax: unit="unit"
| Obs | Disease | Response metric | Exposure route | Exposure metric | Exposure unit | Threshold | ERF parameter | ERF | Description |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Cancer | Lifetime probability of developing cancer | Ingestion | Intake | (mg/kg bw/d)^-1 | Oral CSF | 156000 | US EPA |
Definition
ERF of dioxin on cancer is indexed by variable age. It applies to the last two age categories, i.e. 18-55yr and 55yr+ (gender combined).
Rationale
Data
The U.S. Environmental Protection Agency (US EPA) calculated an oral cancer slope factor (CSF) for 2,3,7,8 - TCDD (the most toxic dioxin compound). This CFS equals to 156000 (mg/kg bw-d)-1 and represents the upper 95th percentile estimate of the probability of developing cancer per unit intake of chemical over a lifetime. [1]
Formula
Unit
(mg/kg bw/d)-1
References
- ↑ US EPA 2000. Guidance for assessing chemical contaminant data for use in fish advisories. Volume 1: Fish sampling and analysis, 3rd edition. http://www.epa.gov/waterscience/fish/advice/volume1/
