Difference between revisions of "ERF of heavy metals on selected endpoints"
From Testiwiki
(first draft based on ESPREME homepage) |
(notes added) |
||
| Line 12: | Line 12: | ||
|+ESPREME project results for ERFs of heavy metals<ref>http://espreme.ier.uni-stuttgart.de/html/ERFs.html ESPREME home page</ref> | |+ESPREME project results for ERFs of heavy metals<ref>http://espreme.ier.uni-stuttgart.de/html/ERFs.html ESPREME home page</ref> | ||
|ID | |ID | ||
| − | |Use | + | |Use<ref>tn: |
| − | | | + | 1 - ERF recommended for usage |
| + | 2 - ERF only recommended for sensitivity analysis | ||
| + | 3- ERF not recommended for usage (e.g. to avoid double counting)</ref> | ||
| + | |Population group<ref>tn: | ||
| + | Minors: Younger than 18 years</ref> | ||
|Pollutant | |Pollutant | ||
|Expoure route | |Expoure route | ||
| − | |Exposure time [years] | + | |Exposure time [years]<ref>tn: |
| + | After which period of exposure will additional risk be observed? [years]</ref> | ||
|Effect | |Effect | ||
| − | |Absolute risk | + | |Absolute risk<ref>tn: |
| + | Additional fraction of "Population group", that will be effected, if concentration value increases by one "Exposure unit respectively intake rate".</ref> | ||
|Exposure unit respectively intake rate | |Exposure unit respectively intake rate | ||
|YLL | |YLL | ||
| Line 24: | Line 30: | ||
|IQ points lost | |IQ points lost | ||
|---- | |---- | ||
| − | |Functions recommended for usage | + | !colspan="12"|Functions recommended for usage |
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
|---- | |---- | ||
|1 | |1 | ||
| Line 108: | Line 103: | ||
|Ingestion | |Ingestion | ||
|1 | |1 | ||
| − | |Still birth | + | |Still birth<ref>tn: |
| + | still birth/adverse pregnancy outcome (2)</ref> | ||
|0.0001044 | |0.0001044 | ||
|ug/day | |ug/day | ||
| Line 133: | Line 129: | ||
|Pb | |Pb | ||
|Inhalation | |Inhalation | ||
| − | |5 | + | |5<ref>tn: |
| + | Minors: Divide by 5 | ||
| + | Exposure Time: Divide by 5, means about 3.6 years effective exposure time.</ref> | ||
|Children's IQ | |Children's IQ | ||
|0.1 | |0.1 | ||
| Line 200: | Line 198: | ||
|70 | |70 | ||
|Cancer 50% fatal | |Cancer 50% fatal | ||
| − | |0.0001 | + | |0.0001<ref>tn: |
| + | per 1ug/m3/70years</ref> | ||
|ug/m3 | |ug/m3 | ||
|9.38 | |9.38 | ||
| Line 208: | Line 207: | ||
|107 | |107 | ||
|1 | |1 | ||
| − | |Age<1 | + | |Age<1<ref>tn: |
| + | In ESPREME this is assumed to be 1% of the population.</ref> | ||
|Pb | |Pb | ||
|Ingestion | |Ingestion | ||
| Line 219: | Line 219: | ||
|1 | |1 | ||
|---- | |---- | ||
| − | |Functions used for sensitivity analysis | + | !colspan="12"|Functions used for sensitivity analysis |
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
|---- | |---- | ||
|6 | |6 | ||
| Line 362: | Line 351: | ||
|0 | |0 | ||
|---- | |---- | ||
| − | |Functions not used in ESPREME/DROPS | + | !colspan="12"|Functions not used in ESPREME/DROPS |
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
|---- | |---- | ||
|14 | |14 | ||
| Line 409: | Line 387: | ||
|Children's IQ | |Children's IQ | ||
|0.48 | |0.48 | ||
| − | |ug/l | + | |ug/l<ref>tn: |
| + | In ESPREME this is assumed to be 1% of the population.</ref> | ||
|0.00 | |0.00 | ||
|0.00 | |0.00 | ||
|1 | |1 | ||
|---- | |---- | ||
| − | |101 | + | |101<ref>tn: |
| − | |3 | + | ERF from Ari Rabl instead of Allison Searl.</ref> |
| + | |3<ref>tn: | ||
| + | See 103</ref> | ||
|All | |All | ||
|Cd | |Cd | ||
| Line 428: | Line 409: | ||
|---- | |---- | ||
|102 | |102 | ||
| − | |3 | + | |3<ref>tn: |
| + | See 2-5</ref> | ||
|All | |All | ||
|As | |As | ||
| Line 441: | Line 423: | ||
|---- | |---- | ||
|105 | |105 | ||
| − | |3 | + | |3<ref>tn: |
| + | See 25</ref> | ||
|All | |All | ||
|Ni | |Ni | ||
| Line 454: | Line 437: | ||
|---- | |---- | ||
|21 | |21 | ||
| − | |2/3 | + | |2/3<ref>tn: |
| + | Could have been used for sensitivity analyis, but Hg is not covered by ESPREME's water and soil distribution model.</ref> | ||
|Minors | |Minors | ||
|Hg | |Hg | ||
| Line 467: | Line 451: | ||
|---- | |---- | ||
|22 | |22 | ||
| − | |2/3 | + | |2/3<ref>tn: |
| + | Could have been used for sensitivity analyis, but Hg is not covered by ESPREME's water and soil distribution model.</ref> | ||
|All | |All | ||
|Hg | |Hg | ||
| Line 488: | Line 473: | ||
=== Unit === | === Unit === | ||
| − | + | Depends on metal and endpoint. | |
=== Formula === | === Formula === | ||
| − | |||
== Result == | == Result == | ||
| Line 498: | Line 482: | ||
==See also== | ==See also== | ||
| − | |||
| − | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Latest revision as of 11:33, 21 October 2009
This page is a variable.
The page identifier is Op_en3737 |
|---|
| Moderator:Jouni (see all) |
|
Give your opinion to the peer rating of the content of this page. |
| Upload data
|
Contents
Scope
What are the exposure-response functions of arsenic (As), nickel (Ni), mercury (Hg), lead (Pb), chromium (Cr), cadmium (Cd) for the relevant health endpoints of each metal?
Definition
Data
| ID | Use[2] | Population group[3] | Pollutant | Expoure route | Exposure time [years][4] | Effect | Absolute risk[5] | Exposure unit respectively intake rate | YLL | YLD | IQ points lost |
| Functions recommended for usage | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 1 | All | As | Ingestion | 70 | Skin cancer | 0.00002 | ug/day | 6.09 | 0.19 | 0 |
| 2 | 1 | All | As | Inhalation | 70 | Skin cancer | 0.0004 | ug/m3 | 6.09 | 0.19 | 0 |
| 3 | 1 | All | As | Inhalation | 70 | Lung cancer | 0.0015 | ug/m3 | 15.95 | 0.26 | 0 |
| 4 | 1 | All | As | Ingestion | 70 | Bladder cancer | 0.0001 | ug/day | 4.63 | 0.36 | 0 |
| 5 | 1 | All | As | Inhalation | 70 | Bladder cancer | 0.000004 | ug/m3 | 4.63 | 0.36 | 0 |
| 8 | 1 | All | As | Ingestion | 1 | Still birth[6] | 0.0001044 | ug/day | 0.00 | 1.28 | 0 |
| 9 | 1 | All | As | Inhalation | 1 | Still birth | 0.002088 | ug/m3 | 0.00 | 1.28 | 0 |
| 17 | 1 | Minors | Pb | Inhalation | 5[7] | Children's IQ | 0.1 | ug/m3 | 0.00 | 0.00 | 1 |
| 23 | 1 | All | Hg | Inhalation | 35 | CHS effects in adults - ataxia | 0.00014 | ug/m3 | 0.01 | 0.12 | 0 |
| 25 | 1 | All | Ni | Inhalation | 70 | Lung cancer | 0.00038 | ug/m3 | 15.95 | 0.26 | 0 |
| 103 | 1 | All | Cd | Inhalation | 70 | Cancer 85% fatal | 0.0018 | ug/m3 | 15.95 | 0.26 | 0 |
| 104 | 1 | All | CrVI | Inhalation | 70 | Cancer 85% fatal | 0.012 | ug/m3 | 15.95 | 0.26 | 0 |
| 106 | 1 | All | PCBs | Inhalation | 70 | Cancer 50% fatal | 0.0001[8] | ug/m3 | 9.38 | 0.15 | 0 |
| 107 | 1 | Age<1[9] | Pb | Ingestion | 1 | Children's IQ | 0.042 | ug/day | 0.00 | 0.00 | 1 |
| Functions used for sensitivity analysis | |||||||||||
| 6 | 2 | All | As | Ingestion | 35 | Cardiovascular mortality | 0.003 | ug/day | 12.80 | 0.00 | 0 |
| 7 | 2 | All | As | Inhalation | 35 | Cardiovascular mortality | 0.02 | ug/m3 | 12.80 | 0.00 | 0 |
| 10 | 2 | All | Cd | Ingestion | 35 | Osteoporosis | 0.008 | ug/day | 0.00 | 0.28 | 0 |
| 11 | 2 | All | Cd | Inhalation | 35 | Osteoporosis | 0.16 | ug/m3 | 0.00 | 0.28 | 0 |
| 12 | 2 | All | Cd | Ingestion | 35 | Renal dysfunction | 0.0004 | ug/day | 0.00 | 0.64 | 0 |
| 13 | 2 | All | Cd | Inhalation | 35 | Renal dysfunction | 0.008 | ug/m3 | 0.00 | 0.64 | 0 |
| 18 | 2 | All | Pb | Food | 1 | Anaemia | 0.000048 | ug/day | 0.00 | 0.64 | 0 |
| 19 | 2 | All | Pb | Water | 1 | Anaemia | 0.0002 | ug/l | 0.00 | 0.64 | 0 |
| 20 | 2 | All | Pb | Inhalation | 1 | Anaemia | 0.0013 | ug/m3 | 0.00 | 0.64 | 0 |
| 24 | 2 | All | Hg | Inhalation | 35 | Renal dysfunction - preclinical effects | 0.002 | ug/m3 | 0.06 | 0.58 | 0 |
| Functions not used in ESPREME/DROPS | |||||||||||
| 14 | 3 | All | CrVI | Inhalation | 70 | Lung cancer | 0.004 | ug/m3 | 15.95 | 0.26 | 0 |
| 15 | 3 | Minors | Pb | Food | 5 | Children's IQ | 0.32 | ug/day | 0.00 | 0.00 | 1 |
| 16 | 3 | Minors | Pb | Water | 5 | Children's IQ | 0.48 | ug/l[10] | 0.00 | 0.00 | 1 |
| 101[11] | 3[12] | All | Cd | Inhalation | 70 | Lung cancer | 0.0018 | ug/m3 | 15.95 | 0.26 | 0 |
| 102 | 3[13] | All | As | Inhalation | 70 | Cancer 85% fatal | 0.0043 | ug/m3 | 15.95 | 0.26 | 0 |
| 105 | 3[14] | All | Ni | Inhalation | 70 | Cancer 85% fatal | 0.00024 | ug/m3 | 15.95 | 0.26 | 0 |
| 21 | 2/3[15] | Minors | Hg | Ingestion | 1 | Children's IQ | 0.149 | ug/day | 0.00 | 0.00 | 1 |
| 22 | 2/3[16] | All | Hg | Ingestion | 35 | CHS effects in adults - ataxia | 0.0013 | ug/day | 0.01 | 0.12 | 0 |
Dependencies
None defined.
Unit
Depends on metal and endpoint.
Formula
Result
See also
References
- ↑ http://espreme.ier.uni-stuttgart.de/html/ERFs.html ESPREME home page
- ↑ tn: 1 - ERF recommended for usage 2 - ERF only recommended for sensitivity analysis 3- ERF not recommended for usage (e.g. to avoid double counting)
- ↑ tn: Minors: Younger than 18 years
- ↑ tn: After which period of exposure will additional risk be observed? [years]
- ↑ tn: Additional fraction of "Population group", that will be effected, if concentration value increases by one "Exposure unit respectively intake rate".
- ↑ tn: still birth/adverse pregnancy outcome (2)
- ↑ tn: Minors: Divide by 5 Exposure Time: Divide by 5, means about 3.6 years effective exposure time.
- ↑ tn: per 1ug/m3/70years
- ↑ tn: In ESPREME this is assumed to be 1% of the population.
- ↑ tn: In ESPREME this is assumed to be 1% of the population.
- ↑ tn: ERF from Ari Rabl instead of Allison Searl.
- ↑ tn: See 103
- ↑ tn: See 2-5
- ↑ tn: See 25
- ↑ tn: Could have been used for sensitivity analyis, but Hg is not covered by ESPREME's water and soil distribution model.
- ↑ tn: Could have been used for sensitivity analyis, but Hg is not covered by ESPREME's water and soil distribution model.
