Difference between revisions of "Estimating exposures to persistent pollutants in infants"
m (Estimating exposures of infants to persistent pollutants via brest feeding moved to Estimating exposures to persistent pollutants in infants: a few typos and an unnecessary restriction to breast feeding) |
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| − | + | [[Category:Exposures]] | |
| − | [[Category: | + | {{method|moderator=Olli}} |
==Scope== | ==Scope== | ||
| − | How to estimate the persistent pollutant intake of infants | + | How to estimate the persistent pollutant intake of infants? |
| + | ==Definition== | ||
| + | |||
| + | Infants are not consuming solid food with persistent pollutants (e.g. fish is the main source of dioxins), however they receive the pollutants via mother's milk. What is the relationship between pollutant concentration of a mother, breast feeding time, and the exposure of an infant? | ||
| + | |||
| + | ==Result== | ||
| − | == | + | ===Exposure via breast-feeding=== |
| − | AUC = C * (1-e<sup>k*t</sup>)/k<sub>e</sub> <ref>[http://heande.opasnet.org/heande/images/f/fb/Alaluusua_et_al_1996.pdf Alaluusua et al 1996]</ref> | + | AUC = C * (1-e<sup>-k*t</sup>)/k<sub>e</sub> <ref>[http://heande.opasnet.org/heande/images/f/fb/Alaluusua_et_al_1996.pdf Alaluusua et al 1996]</ref>, |
| − | + | where AUC is area under the curve C and the duration of breast feeding, C is the measured concentration of polychlorinated dibenzo-p-dioxins/furans as international toxic equivalents, k<sub>e</sub> is elimination constant of polychlorinated dibenzodioxins/furans to milk (k<sub>e</sub> = -0.2877/year) and t is time of nursing (in years). | |
| − | == | + | ==References== |
<references/> | <references/> | ||
Latest revision as of 06:40, 11 July 2009
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Scope
How to estimate the persistent pollutant intake of infants?
Definition
Infants are not consuming solid food with persistent pollutants (e.g. fish is the main source of dioxins), however they receive the pollutants via mother's milk. What is the relationship between pollutant concentration of a mother, breast feeding time, and the exposure of an infant?
Result
Exposure via breast-feeding
AUC = C * (1-e-k*t)/ke [1],
where AUC is area under the curve C and the duration of breast feeding, C is the measured concentration of polychlorinated dibenzo-p-dioxins/furans as international toxic equivalents, ke is elimination constant of polychlorinated dibenzodioxins/furans to milk (ke = -0.2877/year) and t is time of nursing (in years).
