Difference between revisions of "Exposure response function for nitrate and iMetHb"
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== Scope<br> == | == Scope<br> == | ||
| + | To define the exposure response factor for nitrate exposure from drinking water causing iMetHb | ||
*European countries | *European countries | ||
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== Definition<br> == | == Definition<br> == | ||
| − | |||
| − | |||
=== Causality<br> === | === Causality<br> === | ||
| − | + | NA | |
| − | |||
=== Data<br> === | === Data<br> === | ||
| − | Accoding to US EPA IRIS (Integrated Risk Information System) NOAEL for nitrate is 10 mg nitrate-nitrogen/L (1.6 mg/kg/day) and LOAEL is 11-20 mg nitrate-nitrogen/L (1.8-3.2 mg/kg/day). Conversion Factor for nitrate-nitrogen is expressed as the amount of nitrogen within the nitrite molecule commonly shown as mg nitrate-nitrogen/L (1 mg nitrate-nitrogen = 4.4 mg nitrate. The oral Reference Dose (RfD), which is based on the assumption that thresholds exist for certain toxic effects such as cellular necrosis, is 1.6E+0 mg/kg/day. This results in early clinical signs of methemoglobinemia in excess of 10% (0-3 months old infants formula). | + | Accoding to US EPA IRIS (Integrated Risk Information System) NOAEL for nitrate is 10 mg nitrate-nitrogen/L (1.6 mg/kg/day) and LOAEL is 11-20 mg nitrate-nitrogen/L (1.8-3.2 mg/kg/day). Conversion Factor for nitrate-nitrogen is expressed as the amount of nitrogen within the nitrite molecule commonly shown as mg nitrate-nitrogen/L (1 mg nitrate-nitrogen = 4.4 mg nitrate. The oral Reference Dose (RfD), which is based on the assumption that thresholds exist for certain toxic effects such as cellular necrosis, is 1.6E+0 mg/kg/day. This results in early clinical signs of methemoglobinemia in excess of 10% (0-3 months old infants formula). U.S. EPA has evaluated the noncancer oral data for nitrate and derived a reference dose (RfD) of 1.6 mg/kg-day with 10 % of risk to MetHb. |
http://www.epa.gov/NCEA/iris/subst/0076.htm | http://www.epa.gov/NCEA/iris/subst/0076.htm | ||
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=== Formula<br> === | === Formula<br> === | ||
| − | |||
=== Unit<br> === | === Unit<br> === | ||
| − | + | mg/kg/d / mg/l | |
== Result<br> == | == Result<br> == | ||
| − | + | *Slope of exposure response function for nitrate and iMet Hb= 0.06585 | |
| + | *Environmental risk level for NO3- =133.7 mg/l | ||
| + | *No observed adverded effect level (NOEL) for nitrate in drinking water= 1.6 mg/kg/d | ||
| + | *LOAEL for NO3- = 15,5 mg/l | ||
| + | *US EPA reference oral dose for nitrate = 7 mg/kg/d | ||
| + | *Acceptable daily intake of NO3- = 3.7 mg/kg/d | ||
Revision as of 15:34, 27 August 2008
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Scope
To define the exposure response factor for nitrate exposure from drinking water causing iMetHb
- European countries
- Infants < 6 months of age
- Oral exposure from drinking water via baby food formula or drinking water.
Definition
Causality
NA
Data
Accoding to US EPA IRIS (Integrated Risk Information System) NOAEL for nitrate is 10 mg nitrate-nitrogen/L (1.6 mg/kg/day) and LOAEL is 11-20 mg nitrate-nitrogen/L (1.8-3.2 mg/kg/day). Conversion Factor for nitrate-nitrogen is expressed as the amount of nitrogen within the nitrite molecule commonly shown as mg nitrate-nitrogen/L (1 mg nitrate-nitrogen = 4.4 mg nitrate. The oral Reference Dose (RfD), which is based on the assumption that thresholds exist for certain toxic effects such as cellular necrosis, is 1.6E+0 mg/kg/day. This results in early clinical signs of methemoglobinemia in excess of 10% (0-3 months old infants formula). U.S. EPA has evaluated the noncancer oral data for nitrate and derived a reference dose (RfD) of 1.6 mg/kg-day with 10 % of risk to MetHb.
http://www.epa.gov/NCEA/iris/subst/0076.htm
Formula
Unit
mg/kg/d / mg/l
Result
- Slope of exposure response function for nitrate and iMet Hb= 0.06585
- Environmental risk level for NO3- =133.7 mg/l
- No observed adverded effect level (NOEL) for nitrate in drinking water= 1.6 mg/kg/d
- LOAEL for NO3- = 15,5 mg/l
- US EPA reference oral dose for nitrate = 7 mg/kg/d
- Acceptable daily intake of NO3- = 3.7 mg/kg/d
