Difference between revisions of "Health impact assessment"

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Health impact assessment is an assessment method that is used to estimate the health impacts of a particular event or policy. In Europe, it is most widely used in UK, Finland, and the Netherlands.

Question

How to calculate health impacts based on information about exposure, population, disease, and exposure-response function?

Answer

For simple calculations, you can use the concept of attributable fraction. This is presented here. For more complex and comprehensive methods, you may want to consider these:

An example model run by the model below [1].

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#	name:exposuresource|description:Which exposure data do you want to use?|type:selection|options:'Op_en5918';Exposures in Finland|

library(OpasnetUtils)
library(ggplot2)

objects.latest("Op_en5917", "initiate") # [[Disease risk]]
#objects.latest(exposuresource, "initiate") # [[Exposures in Finland]]
objects.latest("Op_en2261", "initiate") # [[Health impact assessment]] dose, RR, totcases, AF
objects.latest('Op_en5827', code_name = 'initiate') # [[ERFs of environmental pollutants]] ERF, threshold

openv.setN(N)

exposure <- 1
bgexposure <- 0 # background exposure
frexposed <- 1 # fraction exposed
BW <- 70 # body weight
population <- 100000 # population size
ls()
disincidence <- disincidence / 100000 # # /100000py -> # /py

cat("Exposure-response functions used:\n")

oprint(summary(EvalOutput(ERF)))

totcases <- EvalOutput(totcases)

cat("Variable totcases for 100000 population and nominal 1 unit exposure.\n")

oprint(summary(totcases), digits = 4)

ggplot(totcases@output, aes(x = Trait, weight = result(totcases)/get("N", envir=openv), fill = Exposure_agent)) + 
	geom_bar() + 
	theme_grey(base_size = 24) +
	theme(axis.text.x = element_text(angle = 90, hjust = 1))

Inputs

If you are able to describe your data in the format similar to the tables below, you can use ready-made tools in Opasnet and things are quite straightforward. The example tables show data about radon in indoor air.

Exposure

The table has an index Observation with four locations: Exposed fraction, Background, Exposure, and Description.

Pollutant	Exposure route	Exposure metric	Exposure parameter	Population	Exposure unit	Exposed fraction	Background	Exposure	Description
Radon	Inhalation	Annual average concentration	Population average	Finland	Bq/m3	1	5	100	Kurttio Päivi, 2006: STUK otantatutkimus 100 (95 – 105); background 5 (4 – 9)
Radon	Inhalation	Annual average concentration	Guidance value for new apartments	Finland	Bq/m3	1	0	200	STM decision 944/92 for new apartments [2]
Radon	Inhalation	Annual average concentration	Guidance value for old apartments	Finland	Bq/m3	1	0	400	STM decision 944/92 for old apartments [3]

Disease response

The table has index Observation with two locations: Response and Description.

Disease	Response metric	Population	Unit	Response	Description
Lung cancer	Incidence	Finland	1/100000 py	38.058	2020/5307690*100000 [4]
Lung cancer	Burden of disease	Finland	DALY	14000	Olli Leino 2010: Includes trachea, bronchus, and lung cancers. [5]

Exposure-response function

Pollutant	Disease	Response metric	Exposure route	Exposure metric	Exposure unit	Threshold	ERF parameter	ERF	Description
Radon	Lung cancer	Incidence	Inhalation	Annual average concentration	Bq/m3	0	RR	1.0016	Darby 2004: 1.0016 (1.0005 – 1.0031)

Population

Population	Year	Sex	Age	Amount	Description
Finland	2010	Total	All	5307690	[6]

Rationale

These are the equations you should use:

RR for exposure = EXP(LN(RR)*(Exposure Result - MAX(Exposure Background, Exposure-response function threshold)))

Attributable fraction in the whole population = Exposed fraction * (RR for exposure – 1) / (Exposed fraction *(RR for exposure – 1)+1)

Extra cases per year =Disease incidence * Population * attributable fraction

Burden of disease of exposure = Burden of disease of the disase * attributable fraction

Personal lifetime risk = Extra cases per year * life expectancy * population

Attributable fraction is (RR-1)/RR=1-1/RR if RR>1. If smaller, you must compare the other way round: control group is considered an exposure to lack of a protective agent and thus the exposure group is the reference. In this comparison, the attributable fraction of lack of protection (AF_lp) is calculated from a new rate ratio RR_lp = 1/RR and

Failed to parse (Missing <code>texvc</code> executable. Please see math/README to configure.): AF_{lp} = 1 - \frac{1}{RR_{lp}} = 1 - \frac{1}{1/RR} = 1 - RR

When multiplied by the number of cases, we get the number of excess cases (that would not have occurred if the population had not been exposed to lack of protection). This comparison is symmetric and we can use either counterfactual situation as the reference just by calculating the difference the other way round, i.e. changing the sign of the value. Therefore, the number of cases avoided with exposure to a protective agent is -AF_lp = RR - 1. So, AF is calculated as 1-1/RR or RR-1 depending on whether RR>1 or not, respectively.

Calculations

Depreciated code

The code was restructured and old code archived 13 June, 2015.
Code AF (attributable fraction) was moved to page Population attributable fraction.
See also Seturi: Excel file, [7]

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library(OpasnetUtils)

dummy <- 0

HIA <- Ovariable("HIA", 
	dependencies = data.frame(Name = "dummy"),
	formula = function(...) {
		cat("This code is outdated. Instead, use Op_en2261/totcases on page Health impact assessment.\n")
	}
)

totcases <- Ovariable("totcases", 
	dependencies = data.frame(Name = "dummy"),
	formula = function(...) {
		cat("This code is outdated. Instead, use Op_en2261/totcases on page Health impact assessment.\n")
	}
)

AF <- Ovariable("AF", 
	dependencies = data.frame(Name = "dummy"),
	formula = function(...) {
		cat("This code is outdated. Instead, use Op_en6211/AF on page Population attributable fraction.\n")
	}
)

objects.store(HIA, totcases, AF, dummy)
cat("Warnings created about old method.\n")

Ovariables for calculating RR

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# This is code Op_en2261/BW on page [[Health impact assessment]].
library(OpasnetUtils)

BW <- Ovariable("BW", data = data.frame(Result = 70)) # 70 kg

objects.store(BW)
cat("Ovariable BW (body weight) stored. page: Op_en2261, code_name: BW.\n")

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# This is code Op_en2261/frexposed on page [[Health impact assessment]].
library(OpasnetUtils)

frexposed <- Ovariable("frexposed", data = data.frame(Result = 1))

objects.store(frexposed)
cat("Ovariable frexposed stored. page: Op_en2261, code_name: frexposed.\n")

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# This is code Op_en2261/exposure on page [[Health impact assessment]].
library(OpasnetUtils)

exposure <- Ovariable("exposure", data = data.frame(Result = 1))

objects.store(exposure)
cat("Ovariable exposure stored. page: Op_en2261, code_name: exposure.\n")

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# This is code Op_en2261/bgexposure on page [[Health impact assessment]].
library(OpasnetUtils)

bgexposure <- Ovariable("bgexposure", data = data.frame(Result = 0))

objects.store(bgexposure)
cat("Ovariable bgexposure stored. page: Op_en2261, code_name: bgexposure.\n")

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# This is code Op_en2261/population on page [[Health impact assessment]].
library(OpasnetUtils)

population <- Ovariable("population", data = data.frame(Result = 1))

objects.store(population)
cat("Ovariable population stored. page: Op_en2261, code_name: population.\n")

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# This is code Op_en2261/incidence on page [[Health impact assessment]].
library(OpasnetUtils)

incidence <- Ovariable("incidence", data = data.frame(Result = 0.1))

objects.store(incidence)
cat("Ovariable incidence stored. page: Op_en2261, code_name: incidence.\n")

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# This is code Op_en2261/dose on page [[Health impact assessment]].
library(OpasnetUtils)

dose <- Ovariable("dose", # This calculates the body-weight-scaled exposure or "dose" to be used with ERFs.
  dependencies = data.frame(
    Name = c(
      "exposure", # Exposure to the pollutants
      "bgexposure", # Background exposure (a level you use for comparison)
      "BW" # body weight
    ),
    Ident = c(
      "Op_en2261/exposure",
      "Op_en2261/bgexposure",
      "Op_en2261/BW"
    )
  ),
  formula = function(...) {
    
    ########### Create a single ovariable with exposure and background exposure.
    
    temp <- Ovariable( # Create alternative scenario with background exposure bgexposure.
      output = data.frame(Exposcen = c("BAU", "No exposure"), Result = c(1, 0)), 
      marginal = c(TRUE, FALSE)
    )
    
    out <- temp * exposure + (1 - temp) * bgexposure # Adds exposure and background to respective scenarios
    
    ######### Body weight scaling: In some cases, exposure is given as per body weight and in some cases as absolute amounts.
    # Here we add one index to define for this difference.
    out2 <- out / BW
    out3 <- log10(out)
    
    out$Scaling <- "None"
    out2$Scaling <- "BW"
    out3$Scaling <- "Log10"
    
    out <- combine(out, out2, out3)
    
    return(out)
  }
)

objects.store(dose)
cat("Ovariable dose stored. page: Op_en2261, code_name: dose.\n")

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# This is code Op_en2261/RR on page [[Health impact assessment]].
library(OpasnetUtils)

# Do we need testforrow any more, as RR does not use it?
testforrow <- function(x, y) {
  if (nrow(x@output) == 0 | nrow(y@output) == 0) return(FALSE)
  commons <- intersect(colnames(x@output), colnames(y@output))
  commons <- commons[!grepl("Result$", commons)]
  for (i in commons) {
    if (!any(unique(x@output[[i]]) %in% unique(y@output[[i]]))) return(FALSE)
  }
  return(TRUE)
}

# This code produces non-unique index combinations. They multiply when 
# formula is run and probably cause bias in results. Check!
RR <- Ovariable(
  "RR", # This calculates the total number of cases in each population subgroup.
  # The cases are calculated for specific (combinations of) causes. However, these causes are NOT visible in the result.
  dependencies = data.frame(
    Name = c(
      "dose", # Exposure to the pollutants
      "ERF", # Exposure-response function of the pollutants or agents (RR for unit exposure)
      "threshold", # exposure level below which the agent has no impact.
      "frexposed", # fraction of population that is exposed
      "incidence", # This is only needed for OR and omitted otherwise.
      "mc2d"  # Function to run two-dimensional Monte Carlo
    ),
    Ident = c(
      "Op_en2261/dose",     # [[Health impact assessment]]
      "Op_en2031/initiate", # [[Exposure-response function]]
      "Op_en2031/initiate", # [[Exposure-response function]]
      "Op_en2261/frexposed",# [[Health impact assessment]]
      "Op_en2261/incidence", # [[Health impact assessment]]
      "Op_en7805/mc2d" # [[Two-dimensional Monte Carlo]]
    )
  ),
  formula = function(...) {
    # Make sure that these are not marginals
    ERF@marginal[colnames(ERF@output) %in% c("ERF_parameter", "Scaling")] <- FALSE 
    # Remove redundant columns
    ERF <- ERF[ , !colnames(ERF@output) %in% c(
      "Source",
      "Exposure_unit"
    )]
    threshold <- threshold[ , !colnames(threshold@output) %in% c(
      "Source",
      "Exposure_unit"
    )]
    out <- NULL
    dose <- dose * ERF # Do the merge now to avoid redundant rows
    result(dose) <- dose$doseResult
    dose <- unkeep(dose, sources=TRUE)
    
    ####################################################################
    ####### This part is about risks relative to background.
    # Calcualte the risk ratio to each subgroup based on the exposure in that subgroup.
    # Combine pollutant-specific RRs by multiplying. For description, see [[Exposure-response function]].
    
    #First take the relative risk estimates. Convert ORs to RRs by using incidence.
    # We need OR but not yet crucial, so let's postpone this. See [[:op_en:Converting between exposure-response parameters]]
    #		#Then take the odds ratio estimates
    #		OR <- ERF[ERF$ERF_parameter %in% c("OR", "OR bw") , ]
    #		if(testforrow(OR, dose)) { # See ERFrr for explanation
    #			out <- OR / (1 - incidence + OR*incidence) # Actual function with background incidence.
    #		}
    
    temp <- dose[dose$ER_function %in% c("RR", "OR") , ]
    if(nrow(temp@output)>0) {
      
      temp <- exp(log(ERF) * (temp - threshold)) # Actual function
      
      result(temp)[temp$doseResult < temp$thresholdResult] <- 1 # RR is 1 below threshold
      out <- temp
    }

    # Then take the relative Hill estimates
    
    temp <- dose[dose$ER_function %in% c("Relative Hill") , ]
    if(nrow(temp@output)>0) {

      temp <- 1 + (temp * ERF) / (temp + threshold)  # Actual function
      
      # ERF has parameter value for Imax. If Imax < 0, risk reduces.
      # threshold has parameter value for ED50.
      if(is.null(out)) out <- temp else out <- combine(out, temp)
    }
    temp <- NULL
    
    if(is.null(out)) {
      out <- oapply(dose, cols = c("Iter","Exposure_agent","Scaling","Exposure"), FUN=sum)
      result(out) <- 1
    } else {
      
      # Dilute the risk in the population if not all are exposed i.e. frexposed < 1.
      out <- frexposed * (out - 1) + 1
      out <- unkeep(out, prevresults = TRUE, sources = TRUE, cols = c("Scaling", "ER_function")) 
      if(length(unique(out$Exposure_agent)) > 1) { # Could we just oapply everything?
        out <- oapply(out, cols = c("Exposure_agent", "Exposure"), FUN = prod) 
      } else {
        out <- unkeep(out, cols = c("Exposure_agent", "Exposure"))
      }
    }
    if(mc2dparam$run2d) out <- mc2d(out) # Run two-dimensional Monte Carlo
    return(out)
  }
)

objects.store(RR, testforrow)
cat("Ovariables RR, testforrow saved. page: Op_en2261, code_name: RR.\n")

Ovariables for calculating cases

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# This is code Op_en2261/sumExposcen on page [[Health impact assessment]].
library(OpasnetUtils)

# sumExposcen calculates the difference between scenarios BAU and No exposure.
sumExposcen <- function (out) {
  if ("Exposcen" %in% colnames(out@output)) {
    out <- out * Ovariable(
      output = data.frame(Exposcen = c("BAU", "No exposure"), Result = c(1, -1)),
      marginal = c(TRUE, FALSE)
    )
    # Remove ERF-related indices as they are no longer needed.
    out <- oapply(out, NULL, sum, c("Exposcen","Exposure","ER_function","Exposure_unit","Scaling"))
  }
  return(out)
}

objects.store(sumExposcen)
cat("Function sumExposcen dose stored. page: Op_en2261, code_name: sumExposcen.\n")

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# This is code Op_en2261/casesabs on page [[Health impact assessment]].
library(OpasnetUtils)

casesabs <- Ovariable(
  "casesabs", # This calculates the burden of disease for background-independent endpoints.
  dependencies = data.frame(
    Name = c(
      "population", # Population divided into subgroups as necessary
      "dose", # Exposure to the pollutants
      "ERF", # Other ERFs than those that are relative to background.
      "threshold", # exposure level below which the agent has no impact.
      "frexposed", # fraction of population that is exposed
      "sumExposcen", # function that calculates difference between exposure scenarios
      "mc2d"  # Function to run two-dimensional Monte Carlo
    ), 
    Ident = c(
      "Op_en2261/population", # [[Health impact assessment]]
      "Op_en2261/dose",       # [[Health impact assessment]]
      "Op_en2031/initiate",   # [[Exposure-response function]]
      "Op_en2031/initiate",   # [[Exposure-response function]]
      "Op_en2261/frexposed",  # [[Health impact assessment]]
      "Op_en2261/sumExposcen",# [[Health impact assessment]]
      "Op_en7805/mc2d"        # [[Two-dimensional Monte Carlo]]
    )
  ),
  formula = function(...) {
    out <- NULL
    dose2 <- dose * ERF # Do the merge first
    result(dose2) <- dose2$doseResult

    temp <- dose2[dose2$ER_function %in% c("UR", "CSF", "ERS"), ]
    
    # Dose could be simplified with combine.
    if(nrow(temp@output)>0) {
      out <- (threshold + temp * ERF * frexposed) * population # Actual equation
      # threshold is here interpreted as the baseline response (intercept of the line). It should be 0 for
      # UR and CSF but it may have meaningful values with ERS
      # But this interpretation is problematic. Threshold should have same units as exposure, not response.
    }

    # Step estimates: value is 1 below threshold and above ERF, and 0 in between.
    
    temp <- dose2[dose2$ER_function %in% c("Step", "ADI", "TDI", "RDI", "NOAEL") , ]
    if(nrow(temp@output)>0) {
      
      temp <- (1 - (temp >= threshold) * (temp <= ERF)) * frexposed * population # Actual equation
      
      if(is.null(out)) out <- temp else out <- combine(out, temp)
    }
    out <- oapply(out, NULL, sum, c("Exposure_agent", "Exposure", "ER_function", "Scaling"))
    if(mc2dparam$run2d) out <- mc2d(out) # Run two-dimensional Monte Carlo
    
    return(sumExposcen(out))
  }
)

objects.store(casesabs)
cat("Ovariable casesabs stored. page: Op_en2261, code_name: casesabs.\n")

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# This is code Op_en2261/casesrr on page [[Health impact assessment]].
library(OpasnetUtils)

casesrr <- Ovariable(
  "casesrr", # This calculates the burden of disease for endpoints using RR.
  dependencies = data.frame(
    Name = c(
      "population", # Population divided into subgroups as necessary
      "RR", # Relative risks for the given exposure
      "incidence", # incidence of responses
      "sumExposcen" # function that calculates difference between exposure scenarios
    ), 
    Ident = c(
      "Op_en2261/population", # [[Health impact assessment]]
      "Op_en2261/RR",         # [[Health impact assessment]]
      "Op_en5917/initiate",   # [[Disease risk]]
      "Op_en2261/sumExposcen" # [[Health impact assessment]]
    )
  ),
  formula = function(...) {
    AF <- (RR > 1) * (1 - 1/RR) + (RR <= 1) * (RR - 1)
    out <- population * incidence * AF

    return(sumExposcen(out))
  }
)

objects.store(casesrr)
cat("Ovariable casesrr stored. page: Op_en2261, code_name: casesrr.\n")

Totcases (old version)

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# This is code Op_en2261/totcases on page [[Health impact assessment]].
library(OpasnetUtils)

totcases <- Ovariable("totcases", # This calculates the total number of cases in each population subgroup.
	# The cases are calculated for specific (combinations of) causes. However, these causes are NOT visible in the result.
	dependencies = data.frame(
		Name = c(
			"population", # Population divided into subgroups as necessary
			"dose", # Exposure to the pollutants
			"disincidence", # Incidence of the disease of interest
			"RR", # Relative risks for the given exposure
			"ERF", # Other ERFs than those that are relative to background.
			"threshold", # exposure level below which the agent has no impact.
			"frexposed" # fraction of population that is exposed
		), 
		Ident = c(
			"Op_en2261/population", # [[Health impact assessment]]
			"Op_en2261/dose",       # [[Health impact assessment]]
			"Op_en5917/initiate",   # [[Disease risk]]
			"Op_en2261/RR",         # [[Health impact assessment]]
			"Op_en2031/initiate",   # [[Exposure-response function]]
			"Op_en2031/initiate",   # [[Exposure-response function]]
			"Op_en2261/frexposed"   # [[Health impact assessment]]
		)
	),
	formula = function(...) {

		test <- list()
		ERF@marginal[colnames(ERF@output) %in% c("ERF_parameter", "Scaling")] <- FALSE # Make sure that these are not marginals
		
		############### First look at the relative risks based on RR
		
		if(testforrow(RR,  dose)) { # If an ovariable whose nrow(ova@output) == 0 
		# is used in Ops, it is re-EvalOutput'ed, and therefore ERFrr*dose may have rows even if ERFrr doesn't.
					
			# takeout is a vector of column names of indices that ARE in population but NOT in the disease incidence.
			# However, populationSource is kept because oapply does not run if there are no indices.

			if(class(population) == "ovariable") {
				takeout <- setdiff(colnames(population@output)[population@marginal],
					colnames(disincidence@output)[disincidence@marginal]
				)
				if(length(takeout) > 0) {# Aggregate to larger subgroups.
					pop <- oapply(population, NULL, sum, takeout)
				} else {
					pop <- population
				}
			} else {
				takeout <- character()
				pop <- population
			}

			# pci is the proportion of cases across different population subroups based on differential risks and
			# population sizes. pci sums up to 1 for each larger subgroup found in disincidence. 
			# See [[Population attributable fraction]].
			pci <- population * RR
			# Divide pci by the values of the actually exposed group (discard nonexposed)
			# The strange Ovariable thing is needed to change the name of temp to avoid problems later.
			temp <- pci * Ovariable(data = data.frame(Result = 1))
			if ("Exposcen" %in% colnames(temp@output)) {
				temp@output <- temp@output[temp@output$Exposcen == "BAU" , ]
				temp <- unkeep(temp, cols = "Exposcen", prevresults = TRUE, sources = TRUE)
			}
			temp <- unkeep(temp, prevresults = TRUE, sources = TRUE)
			if(length(takeout) > 0) temp <- oapply(temp, NULL, sum, takeout)
			#if(length(takeout) > 0) temp <- ooapply(temp, cols = takeout, FUN = "sum", use_plyr = TRUE)
#			if(length(takeout) > 0) temp <- osum(temp, cols = takeout)
			pci <- pci / temp
			temp <- NULL

			# The cases are divided into smaller subgroups based on weights in pci.
			# This is why the larger groups of population are used (pop instead of population).
			out1 <- disincidence * pop * unkeep(pci, prevresults = TRUE, sources = TRUE)
			out1 <- unkeep(out1, cols = "populationResult") # populationResult comes from pop and not from pci that actually contains
			# the population weighting for takeout indices. Therefore it would be confusing to leave it there.
			test <- c(test, out1)
		}
		out1 <- NULL

		##########################################################################
		############# This part is about absolute risks (i.e., risk is not affected by background rates).
		
		# Unit risk (UR), cancer slope factor (CSF), and Exposure-response slope (ERS) estimates.
		
		UR <- ERF
		UR@output <- UR@output[UR@output$ERF_parameter %in% c("UR", "CSF", "ERS") , ]
		if(testforrow(UR, dose)) { # See RR for explanation.
			UR <- threshold + UR * dose * frexposed # Actual equation
			# threshold is here interpreted as the baseline response (intercept of the line). It should be 0 for
			# UR and CSF but it may have meaningful values with ERS

			UR <- oapply(UR, NULL, sum, "Exposure_agent")

			UR <- population * UR
			test <- c(test, UR)
		}
		UR <- NULL

		# Step estimates: value is 1 below threshold and above ERF, and 0 in between.
		# frexposed cannot be used with Step because this may be used at individual and maybe at population level.
		Step <- ERF
		Step@output <- Step@output[Step@output$ERF_parameter %in% c("Step", "ADI", "TDI", "RDI", "NOAEL") , ]
		if(testforrow(Step, dose)) { # See RR for explanation.
			Step <- 1 - (dose >= threshold) * (dose <= Step) # Actual equation
			# Population size should be taken into account here. Otherwise different population indices may go unnoticed.(?)

			Step <- oapply(Step, NULL, sum, "Exposure_agent")

			test <- c(test, Step)
		}
		Step <- NULL
	
		#####################################################################
		# Combining effects
		if(length(test) == 0) return(data.frame())
		if(length(test) == 1) out <- test[[1]]@output
		if(length(test) == 2) out <- orbind(test[[1]], test[[2]])
		if(length(test) == 3) out <- orbind(orbind(test[[1]], test[[2]]), test[[3]])

		# Find out the right marginals for the output
		marginals <- character()
		nonmarginals <- character()
		for(i in 1:length(test)) {
			marginals <- c(marginals, colnames(test[[i]]@output)[test[[i]]@marginal])
			nonmarginals <- c(nonmarginals, colnames(test[[i]]@output)[!test[[i]]@marginal])
		}
		
		test <- NULL
		out <- out[!colnames(out) %in% c("populationSource", "populationResult")] # These are no longer needed.

		out <- Ovariable(output = out, marginal = colnames(out) %in% setdiff(marginals, nonmarginals))

		if("Exposcen" %in% colnames(out@output)) {
			out <- out * Ovariable(
				output = data.frame(Exposcen = c("BAU", "No exposure"), Result = c(1, -1)),
				marginal = c(TRUE, FALSE)
			)
			out <- oapply(out, NULL, sum, "Exposcen")
		}
		
		return(out)
	}
)

objects.store(totcases)
cat("Ovariable totcases saved. page: Op_en2261, code_name: totcases.\n")

NOTE! These ovariables used to utilise ooapply function, but it was archived after improved oapply.

The codes above are based on these input variables:

Exposure-response function
Disease risk (case-spacific data)
Exposures in Finland (case-specific data)
Burden of disease in Finland
Disability weights (not used yet)
Duration of morbidity (not used yet)
heande:File:Impact Calculation Tool.ana (not used, but functionalities should be merged to this page)

Integrated health measures

Common health measures include mortality, morbidity, healthy life expectancy, attributable burden of disease measures, and monetary valuation. Some of these measures will be further described below. All methods have several associated difficulties, such as imprecision of the population exposure assessment; uncertain shapes of the exposure-response curves for the low environmental exposure levels; insufficient (quality of) epidemiological data; extrapolation from animal to man or from occupational to the general population; generalisation of exposure-response relations from locally collected data for use on regional, national or global scale; combined effects in complex mixtures, etc.

Mortality figures The annual mortality risk or the number of deaths related to a certain (environment-related) disease can be compared with this risk or number in another region or country, or with data from another period in time. Subsequently, different policies can be compared and policies that do or do not work can be identified. Within a country, time trends can be analyzed. This method is easy to comprehend. No ethical questions are attached; everyone is treated equal. Since this method only includes mortality, it is not suitable for assessing factors with less severe consequences (morbidity). Also, it is difficult to attribute mortality to specific environmental causes.

Morbidity figures Similar to mortality figures, morbidity numbers (prevalences or incidences based on hospital admissions or doctor visits) can be used to evaluate a (population) health state. Advantages and drawbacks are comparable to those applying to using mortality figures. The use of morbidity numbers is therefore similarly limited, especially when (environmental) causes of the diseases vary.

Healthy life expectancy Using mortality tables, one can calculate the total average life expectancy for different age groups in a population, subdivided into years with good and years with less-than-good health. This measure is especially useful to review the generic health state in a country for the long term, but it doesn’t give insight into specific health effects, effects of specific policy interventions, or trends in certain subgroups.

Attributable burden of disease Health impact assessments can also be executed by calculating the attributable burden of disease. There are several ways to assess the burden of disease attributable to an (environmental) factor, such as the QALY and the DALY. Quality Adjusted Life Years, QALYs, capture both the quality and quantity elements of health in one indicator. Essentially, time spent in ill health (measured in years) is multiplied by a weight measuring the relative (un)desirability of the illness state. Thereby a number is obtained which represents the equivalent number of years with full health. QALYs are commonly used for cost-utility analysis and to appraise different forms of health care. To do that, QALYs combine life years gained as a result of these health interventions/health care programs with a judgment about the quality of these life years. Disability adjusted life years, DALYs, are comparable to QALYs in that they both combine information on quality and quantity of life. However, contrary to QALYs, DALYs give an indication of the (potential) number of healthy life years lost due to premature mortality or morbidity and are estimated for particular diseases, instead of a health state. Morbidity is weighted for the severity of the disorder.

With QALY, the focus is on assessing individual preference for different non-fatal health outcomes that might result from a specific intervention, whereas the DALY was developed primarily to compare relative burdens among different diseases and among different populations (Morrow and Bryant, 1995). DALYs are suitable for analyzing particular disorders or specific factors that influence health. Problems associated with the DALY approach include the difficulty of estimating the duration of the effects (which have hardly been studied) and the severity of a disease; and allowing for combined effects in the same individual (first you have symptoms, then you go to a hospital and then you may die). The DALY concept, which has been used in our study, will be further described in the next chapter. More information on the drawbacks of the method can be found in Chapter 6.4.

Monetary valuation Another approach to health impact assessment is monetary valuation. In this measure, money is used as a unit to express health loss or gain, thereby facilitating the comparison of policy costs and benefits. It can help policy makers in allocating limited (health care) resources and setting priorities. There are different approaches to monetary valuation such as ‘cost of illness’ and ‘willingness to pay/accept’.

The cost of illness (COI) approach estimates the material costs related to mortality and morbidity. It includes the costs for the whole society and considers loss of income, productivity and medical costs. This approach does not include immaterial costs, such as impact of disability (pain, fear) or decrease in quality of life. This could lead to an underestimation of the health costs. Furthermore, individual preferences are not considered.

The willingness to pay (WTP) approach measures how much money one would be willing to pay for improvement of a certain health state or for a reduction in health risk. The willingness to accept (WTA) approach measures how much money one wants to receive to accept an increased risk. WTP and WTA can be estimated by observing the individual’s behaviour and expenditures on related goods (revealed preference). For example, the extra amount of money people are willing to pay for safer or healthier products (e.g. cars with air bags), or the extra salary they accept for compensation of a risky occupation (De Hollander, 2004). Another similar method is contingent valuation (CV), in which people are asked directly how much money they would be willing to pay (under hypothetical circumstances) for obtaining a certain benefit (e.g. clean air or good health).

Source: Knol, A.B. en Staatsen, B.A.M. (2005). Trends in the environmental burden of disease in the Netherlands, 1980-2020. Rapport 500029001, RIVM, Bilthoven. Downloadable at http://www.rivm.nl/bibliotheek/rapporten/500029001.html

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Yhteenveto	Helsingin energiapäätös 2015 \| Helsingin energiapäätöksen vaihtoehdot 2015 \| Helsingin energiapäätökseen liittyviä arvoja \| Helsingin energiapäätös 2015.pptx

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Latest revision as of 10:18, 6 September 2017

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