Difference between revisions of "Infant's dioxin exposure"
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# Technical conversion | # Technical conversion | ||
out <- out[out$Exposure_agent == "TEQ" , ] | out <- out[out$Exposure_agent == "TEQ" , ] | ||
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return(out) | return(out) | ||
} | } |
Revision as of 16:37, 30 May 2017
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Question
How to measure infant's dioxin exposure due to fetal period and breast feeding?
Answer
Mother's exposure at level 100 pg /d (fairly typical amount) will lead to child's TEQ concentration of 44 pg /g fat (logTEQ 3.8).
Rationale
Inputs
Obs | Parametre | Value | Description |
---|---|---|---|
1 | TEQ half-life | 2737.5 | t0.5: 7.5 * 365, Dioxin half-life in adults (d) |
2 | TEQ fraction absorbed | 0.8 | f_ing: 0.80, Fraction of dioxin ingested that is actually absorbed (-) |
3 | TEQ fraction to child | 0.1 - 0.25 | f_mtoc: 0.25, Fraction of mother's dioxin burden that enters the child during breast-feeding in 6 mo. Alaluusua et Vartiainen (-) |
4 | Body fat in infant | 1580 | BF: 0.2 * (7.692+8.141) / 2, body fat amount in the infant at six months of age (g) [[:op_en:Body weight of 0-24 months old Finnish children]]. |