Lateral chlorines
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lateral chlorines, the four chlorine atoms in a PCDD/F molecule in positions 2, 3, 7, and 8 (see chemical structures). These four chlorines are required for binding to the AH receptor and toxic effects. They also stabilise the molecule against metabolism, which increases their half-life and tendency for accumulation. PCDD/Fs without lateral chlorines are rapidly metabolised, which prevents their accumulation in the food chain.
