Difference between revisions of "Point of departure"
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(New page: {{encyclopedia|moderator=Reetta}} <section begin=glossary /> :'''Point of departure (POD)''' is a the point on a dose-response curve established from experimental data, e.g., the [[benchm...) |
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| − | :'''Point of departure (POD)''' is a the point on a dose-response curve established from experimental data, e.g., the [[benchmark dose]], generally corresponding to an estimated low effect level (e.g., 1% to 10% incidence of an effect). Depending on the mode of action and available data, some form of extrapolation below the [[POD]] may be employed for low-dose risk assessment or the [[POD]] may be divided by a series of uncertainty factors to arrive at a reference dose.<ref name="WHO report">[http://www.who.int/ipcs/methods/harmonization/draft_document_for_comment.pdf WHO Report]</ref> | + | :'''Point of departure (POD)''' is a the point on a [[:en:Dose-response relationship|dose-response curve]] established from experimental data, e.g., the [[benchmark dose]], generally corresponding to an estimated low effect level (e.g., 1% to 10% incidence of an effect). Depending on the mode of action and available data, some form of extrapolation below the [[POD]] may be employed for low-dose risk assessment or the [[POD]] may be divided by a series of uncertainty factors to arrive at a reference dose.<ref name="WHO report">[http://www.who.int/ipcs/methods/harmonization/draft_document_for_comment.pdf WHO Report]</ref> |
<section end=glossary /> | <section end=glossary /> | ||
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<section begin=glossary />
- Point of departure (POD) is a the point on a dose-response curve established from experimental data, e.g., the benchmark dose, generally corresponding to an estimated low effect level (e.g., 1% to 10% incidence of an effect). Depending on the mode of action and available data, some form of extrapolation below the POD may be employed for low-dose risk assessment or the POD may be divided by a series of uncertainty factors to arrive at a reference dose.[1]
<section end=glossary />
