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- ...ost important risk, and there was uncertainty and disagreement of the dose extrapolation. Recent epidemiological studies after high occupational and accidental expo ...ter tolerates a thousandfold higher dose. The reasons for these intra- and interspecies differences are unclear, but some are due to differences in the AH receptor19 KB (2,951 words) - 10:24, 1 June 2011
- Bokkers BG, Slob W: Deriving a data-based interspecies assessment factor using the NOAEL and the benchmark dose approach. Crit Rev ...ns based on the NOAEL and the benchmark approach for subchronic-to-chronic extrapolation. Toxicol Sci 85, 1033-40, 2005.24 KB (3,561 words) - 19:07, 25 September 2014
- metric for interspecies extrapolation. At present, the WHO24 KB (3,453 words) - 08:21, 23 May 2017
- [[Category:Interspecies extrapolation]]993 bytes (126 words) - 06:33, 18 June 2010
- [[Category:Interspecies extrapolation]]793 bytes (103 words) - 08:37, 4 August 2010
- |Guidance documents (pdf)||Exposure assessment||Interspecies extrapolation||[[Anatomical and physiological differences between various species used in ...discusses issues such as validation, input data needs, time resolution and extrapolation of the model results to174 members (1 subcategory, 0 files) - 08:49, 2 May 2014
- ...s in animal studies will also be the most sensitive effects in humans. The extrapolation requires and in such cases extrapolation from animals to humans will be required, e.g. tolerable upper intake93 KB (14,186 words) - 10:12, 15 June 2012
- |Extrapolation * Threshold assumption, low-dose extrapolation140 KB (21,040 words) - 07:33, 4 March 2015