INTERA: Di-methyl fumarate in consumer products

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Scope

Di-methyl fumarate concentrations in consumer products that are sold in Europe.

Definition

Data

According to the Hong Kong Trade Development Council (HKTDC) shoes, sofas and chair account for more than 90% of the total DMF products entered in EU (Hong Kong Trade Development Council, 2009). Other consumer products include toys and helmets (reported in the RAPEX database). A case of occupational exposure after contact with working trousers has also been reported (Foti et al. 2009).

The European RAPEX database (RAPEX 2011) provided 185 results (2005-2011) of products which were contaminated with DMF (Table 1).

Unit

mg/kg, ppm or μg/cm².

Result

INTERA: Di-methyl fumarate in consumer products(mg/kg, ppm, ug/cm^2)

Obs	Country	Product	Exposure type	Statistical parameter	Ref	Unit	Result
1	Denmark	Shoes	Before exposure	Single value	1	mg/kg	> 0.1
2	Estonia, Hungary, Poland, Italy, Finland, Germany, Slovakia, France, Bulgaria, Spain, Sweden	Shoes	Before exposure	Min	2	mg/kg	0.14
3	Estonia, Hungary, Poland, Italy, Finland, Germany, Slovakia, France, Bulgaria, Spain, Sweden	Shoes	Before exposure	Max	2	mg/kg	5409
4	Estonia, Hungary, Poland, Italy, Finland, Germany, Slovakia, France, Bulgaria, Spain, Sweden	Jeans	Before exposure	Min	2	mg/kg	0.2
5	Estonia, Hungary, Poland, Italy, Finland, Germany, Slovakia, France, Bulgaria, Spain, Sweden	Jeans	Before exposure	Max	2	mg/kg	0.5
6	Estonia, Hungary, Poland, Italy, Finland, Germany, Slovakia, France, Bulgaria, Spain, Sweden	Children’s hat	Before exposure	Single value	2	mg/kg	1.7
7	Hungary, Italy, Spain, Germany, Portugal, Estonia, Bulgaria, Holland, Greece, Cyprus, Poland, Finland, France, Sweden	Shoes	Before exposure	Min	3	mg/kg	0.11
8	Hungary, Italy, Spain, Germany, Portugal, Estonia, Bulgaria, Holland, Greece, Cyprus, Poland, Finland, France, Sweden	Shoes	Before exposure	Max	3	mg/kg	2749
9	Sweden, Poland, France	Shoes	Before exposure	Unspecified	4	mg/kg	19
10	Spain	Shoes	After exposure	Min	5	ppm	3
11	Spain	Shoes	After exposure	Max	5	ppm	95
12	Spain	Shoes	After exposure	Min	5	ug/cm2	10
13	Spain	Shoes	After exposure	Max	5	ug/cm2	46
14	Portugal	Red boots	After exposure	Min	6	ppm	1.3
15	Portugal	Red boots	After exposure	Max	6	ppm	11
16	Portugal	Black boots	After exposure	Min	6	ppm	120
17	Portugal	Black boots	After exposure	Max	6	ppm	640
18	Sweden	Shoes	After exposure	Min	7	ppm	0.22
19	Sweden	Shoes	After exposure	Max	7	ppm	2.8
20	France	Slippers	After exposure	Min	8	ppm	0.18
21	France	Slippers	After exposure	Max	8	ppm	610
22	France	Sofa	After exposure	Single value	8	ppm	0.5
23	Finland	Chair	After exposure	Min	9	ppm	41
24	Finland	Chair	After exposure	Max	9	ppm	400

See also

Links to relevant information that does not belong to Definition.

References

To be updated

1. RAPEX, advanced 18-04-2011, European Commission, http://ec.europa.eu/consumers/dyna/rapex/rapex_archives_en.cfm

Fraga A, Silva R, Filipe P, Scharrer K, Da Costa J.B, Nußbaum P and Gomes M.M (2010). Allergic contact dermatitis to dimethyl fumarate in footwear. Contact Dermatitis 2010: 62: 121–123

Gimenez-Arnau A, Silvestre J.F, Mercader P, De La Cuadra J, Ballester I, Gallardo F, Pujol, R.M, Zimerson E and Bruze M. (2009). Shoe contact dermatitis from dimethyl fumarate: clinical manifestations, patch test results, chemical analysis, and source of exposure. Contact Dermatitis 2009: 61: 249–260

Hasan T, Zimerson E. and Bruze M (2010), Persistent Shoe Dermatitis Caused by Dimethyl Fumarate. Acta Dermato-Venereologica 2010: 90: 553-554

Retho C, Accessed 1st March 2011. Analysis of dimethylfumarate. European Commission meeting on 16 June 2009. http://ec.europa.eu/consumers/safety/projects/index_en.htm#dmf

Rantanen T, (2008)The cause of the Chinese sofa/chair dermatitis epidemic is likely to be contact allergy to dimethylfumarate, a novel potent contact sensitizer. British Journal of Dermatology 2008 159, pp218–221

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INTERA: Di-methyl fumarate in consumer products. Opasnet . [1]. Accessed 18 Jun 2024.