Difference between revisions of "Intake of PCDD/F from fish in Beneris"

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[[Category:Beneris]]
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[[Category:Fish]]
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[[Category:Exposures]]
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[[Category:Dioxins]]
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== '''Scope'''  ==
 
== '''Scope'''  ==
  
 
<br> '''Intake of PCDD/Fs from fish''' describes the exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) due to fish consumption in the [[Benefit-risk assessment of fish consumption for Beneris#Beneris population|Beneris population]].  
 
<br> '''Intake of PCDD/Fs from fish''' describes the exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) due to fish consumption in the [[Benefit-risk assessment of fish consumption for Beneris#Beneris population|Beneris population]].  
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*[[Body weight in Finland|Body weight in Finland]]
 
*[[Body weight in Finland|Body weight in Finland]]
  
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=== Data<!--[if gte mso 10]>
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=== Data ===
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'''Lifetime cancer risk''' associated with PCDD/Fs is usually estimated using cancer slope factor (CSF) and the lifetime average daily dose (LADD). Therefore, in this case the intake of PCDD/Fs from fish is expressed as LADD. LADD is calculated as a product of average daily dose (ADD) and the ratio of exposure duration and averaging time (=life expectancy at birth), where ADD is the product of average WHO-TEQ concentration of PCDD/Fs in fish and fish intake rate (daily intake of fish) divided by the body weight.
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<![endif]--> <br>  ===
 
  
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Lifetime cancer risk associated with PCDD/Fs is usually estimated using cancer slope factor (CSF) and the lifetime average daily dose (LADD). Therefore the intake of PCDD/Fs from fish is expressed as LADD. LADD is calculated as a product of average daily dose (ADD) and the ratio of exposure duration and lifetime, where ADD is the product of concentration of PCDD/Fs in fish and fish intake rate (daily intake of fish) divided by the body weight (kg).<span style="">&nbsp; </span>  
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It is assumed that the exposure duration for people from a given age group is the number of years this age group covers. In other words it is assumed that people from a given age group are exposed to PCDD/Fs from the time of entry to this age group until the time of exit from this age group. Therefore, the exposure duration for age group 18-55yr is 37 years and it's 45 years for age group 55yr+ (assuming max age of 100 years). <br>  
  
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It is assumed that the exposure duration for people from a given age group is the number of years this age group covers. In other words it is assumed that people from a given age group are exposed to PCDD/Fs from the time of entry to this age group until the time of exit from this age group. For example the exposure duration for age group 18-55yr is 37 years. <br>
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Moreover, according to the WHO statistics <ref> World Health Statistics 2008, http://www.terkko.helsinki.fi/english/who/terkkomaterials.htm </ref> the life expectancy at birth in 2006 was 83 and 76 years for Finnish women and men, respectively, and the combined life expectancy was 79 years.  
  
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Moreover, the average lifetime is 82.9 and 75.9 for Finnish women and men, respectively<ref>http://www.stat.fi/tup/suoluk/suoluk_vaesto_en.html</ref>.
 
  
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<br>
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To evaluate '''non-cancer risks''' the average daily dose (ADD) of PCDD/Fs is used. For children, the ADD of PCDD/Fs from fish is estimated as a product of daily fish consumption and
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the average WHO-TEQ concentration of PCDD/Fs in fish divided by the body weight.
  
 
=== Formula  ===
 
=== Formula  ===
  
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<br>  
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General formulas (omitting unit conversions): <br>
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ADD_species(i)=Average_WHO-TEQ_PCDD/Fs_concentration_species(i)*Daily_consumption_species(i)/BW <br>
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LADD_species(i)=Average_WHO-TEQ_PCDD/Fs_concentration_species(i)*Daily_consumption_species(i)*Exposure_duration/(BW*Life_expectancy_at_birth)
  
 
=== Unit  ===
 
=== Unit  ===
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'''ADD''': pg WHO-TEQ/kg bw-day <br>
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'''LADD''': mg/kg bw-day
  
 
== See also  ==
 
== See also  ==
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== Result  ==
 
== Result  ==
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== References  ==
 
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<references />
 

Latest revision as of 10:00, 29 September 2009

Scope


Intake of PCDD/Fs from fish describes the exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) due to fish consumption in the Beneris population.

Definition

Intake of PCDD/F from fish in Beneris is represented as a continuous variable and is indexed by variable age. It applies to the whole Beneris population (all age groups 0-2yr, 2-18yr, 18-55yr and 55yr+) and to indicators such as remaining lifetime risk of cancer in adults and risk of developmental dental defects.

Causality

List of parents:

Data

Lifetime cancer risk associated with PCDD/Fs is usually estimated using cancer slope factor (CSF) and the lifetime average daily dose (LADD). Therefore, in this case the intake of PCDD/Fs from fish is expressed as LADD. LADD is calculated as a product of average daily dose (ADD) and the ratio of exposure duration and averaging time (=life expectancy at birth), where ADD is the product of average WHO-TEQ concentration of PCDD/Fs in fish and fish intake rate (daily intake of fish) divided by the body weight.

It is assumed that the exposure duration for people from a given age group is the number of years this age group covers. In other words it is assumed that people from a given age group are exposed to PCDD/Fs from the time of entry to this age group until the time of exit from this age group. Therefore, the exposure duration for age group 18-55yr is 37 years and it's 45 years for age group 55yr+ (assuming max age of 100 years).

Moreover, according to the WHO statistics [1] the life expectancy at birth in 2006 was 83 and 76 years for Finnish women and men, respectively, and the combined life expectancy was 79 years.


To evaluate non-cancer risks the average daily dose (ADD) of PCDD/Fs is used. For children, the ADD of PCDD/Fs from fish is estimated as a product of daily fish consumption and the average WHO-TEQ concentration of PCDD/Fs in fish divided by the body weight.

Formula

General formulas (omitting unit conversions):
ADD_species(i)=Average_WHO-TEQ_PCDD/Fs_concentration_species(i)*Daily_consumption_species(i)/BW
LADD_species(i)=Average_WHO-TEQ_PCDD/Fs_concentration_species(i)*Daily_consumption_species(i)*Exposure_duration/(BW*Life_expectancy_at_birth)

Unit

ADD: pg WHO-TEQ/kg bw-day
LADD: mg/kg bw-day

See also

TemaNord report on PCDD/F and PCB in Nordic countries

Result

  1. ↑ World Health Statistics 2008, http://www.terkko.helsinki.fi/english/who/terkkomaterials.htm
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