Difference between revisions of "Myocardial infarction risk in adults in Beneris"

From Testiwiki
Jump to: navigation, search
 
(4 intermediate revisions by 3 users not shown)
Line 1: Line 1:
 +
{{variable}}
 +
[[Category: Health effects]]
 +
[[Category:Beneris]]
 +
 
'''Scope'''<br>
 
'''Scope'''<br>
'''Myocardial infarction risk in adults''' describes the remaining lifetime risk of having a myocardial infarction in adults as a result of exposure to methyl mercury, selenium and fish oils through fish consumption in the target European country.
+
'''Myocardial infarction risk in adults in Beneris''' describes the relationship between exposure to omega-3 fatty acids (EPA+DHA) and methyl mercury (MeHg) in fish and the mortality from coronary heart disease (CHD) in adult Beneris population.
  
 
== Definition ==  
 
== Definition ==  
Myocardial infarction in adults is represented as a function of parent variables and is indexed by variable age. It applies to last two age categories and to adults in general (individuals aged 18 years and older).   
+
'''Myocardial infarction in adults''' is represented as a function of parent variables and is indexed by variable age. It applies to two age groups, i.e adults aged 18-55yr and 55yr+ (gender combined).   
  
 
=== Causality ===  
 
=== Causality ===  
 
List of parents:
 
List of parents:
*[[Variable:Fish oil intake]]
+
*[[Mortality in Finland]] - represents baseline CHD mortality in Finland
*[[Variable:Selenium intake from fish]]
+
*[[Fish oil intake in Beneris]]
*[[Variable:MeHg intake from fish]]
+
*[[Methyl mercury intake from fish in Beneris]]
*[[Variable:Socio-economic status]]
+
*[[ERF of omega-3 fatty acids on CVD risk in adults ]]
*[[Variable:Smoking status]]
+
*[[ERF of methyl mercury on CVD risk in adults]]
*[[Variable:Exposure-response of fish oil intake for MI risk in adults]]
 
*[[Variable:Exposure-response of Se intake for MI risk in adults]]
 
*[[Variable:Exposure-response of MeHg intake for MI risk in adults]]
 
*[[Variable:Exposure-response of MeHg and Se interaction for MI risk in adults]]
 
  
 
=== Data ===  
 
=== Data ===  
  
 +
Baseline CHD mortality represents the annual CHD mortality rate in Finland in 2006. It is estimated based on [[Mortality in Finland]] and equals to 1.5 and 72 cases per 10,000 person-years in age groups 18-55yr and 55yr+, respectively.   
 +
 
 
=== Formula ===  
 
=== Formula ===  
 +
CHD_Mortality = Baseline_CHD_mortality*exp[ERF_of_MeHg*(MeHg_Intake_Fish-Average_MeHg_Intake_Fish)+ if(n3_Intake_Fish*BW<=250,ERF1_of_n3_Fish_Intake*(n3_Intake_Fish-Average_n3_Intake_Fish1), ERF2_of_n3_Fish_Intake*(n3_Intake_Fish-Average_n3_Intake_Fish2))]
  
*the (remaining) lifetime risk of myocardial infarction for adults between 18 and 55 years of age:
+
=== Unit ===
 
 
MI_risk_18_55yr = 1/(1+e^(-(0.5-0.0006*37*(fatty_acids18_55-16)+0.003*37*(mehg18_55-37)-0.0005*37*(selenium18_55-0.29)-0.03*(socioeconomic_status18_55-8)+
 
0.01*37*(smoking_status18_55-2.023)-0.0005*37*37*(mehg18_55-37)*(selenium18_55-0.29))))
 
  
*the (remaining) lifetime risk of myocardial infarction for adults older than 55 years:
+
#cases per 10,000 person-years
MI_risk_over55yr = 1/(1+e^(-(0.55-0.0037*20*(fatty_acids55-15)+0.003*20*(mehg55-31)-0.0037*20*(selenium55-0.24)-0.005*(socioeconomic_status55-10)+
 
0.03*20*(smoking_status55-2.023)-0.00037*20*20*(mehg55-31)*(selenium55-0.24))))
 
 
 
*the (remaining) lifetime risk of myocardial infarction for adults older than 18 years:
 
 
 
MI_risk = 0.6*MI_risk_18_55yr+0.4*MI_risk_over55yr
 
 
 
=== Unit ===
 
  
 
== Result ==
 
== Result ==

Latest revision as of 10:25, 29 September 2009

Scope
Myocardial infarction risk in adults in Beneris describes the relationship between exposure to omega-3 fatty acids (EPA+DHA) and methyl mercury (MeHg) in fish and the mortality from coronary heart disease (CHD) in adult Beneris population.

Definition

Myocardial infarction in adults is represented as a function of parent variables and is indexed by variable age. It applies to two age groups, i.e adults aged 18-55yr and 55yr+ (gender combined).

Causality

List of parents:

Data

Baseline CHD mortality represents the annual CHD mortality rate in Finland in 2006. It is estimated based on Mortality in Finland and equals to 1.5 and 72 cases per 10,000 person-years in age groups 18-55yr and 55yr+, respectively.

Formula

CHD_Mortality = Baseline_CHD_mortality*exp[ERF_of_MeHg*(MeHg_Intake_Fish-Average_MeHg_Intake_Fish)+ if(n3_Intake_Fish*BW<=250,ERF1_of_n3_Fish_Intake*(n3_Intake_Fish-Average_n3_Intake_Fish1), ERF2_of_n3_Fish_Intake*(n3_Intake_Fish-Average_n3_Intake_Fish2))]

Unit

#cases per 10,000 person-years

Result