Difference between revisions of "Intake of PCDD/F from fish in Beneris"
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<br> '''Intake of PCDD/Fs from fish''' describes the exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) due to fish consumption in the [[Benefit-risk assessment of fish consumption for Beneris#Beneris population|Beneris population]]. | <br> '''Intake of PCDD/Fs from fish''' describes the exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) due to fish consumption in the [[Benefit-risk assessment of fish consumption for Beneris#Beneris population|Beneris population]]. | ||
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*[[Body weight in Finland|Body weight in Finland]] | *[[Body weight in Finland|Body weight in Finland]] | ||
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| − | Lifetime cancer risk associated with PCDD/Fs is usually estimated using cancer slope factor (CSF) and the lifetime average daily dose (LADD). Therefore the intake of PCDD/Fs from fish is expressed as LADD. LADD is calculated as a product of average daily dose (ADD) and the ratio of exposure duration and lifetime, where ADD is the product of concentration of PCDD/Fs in fish and fish intake rate (daily intake of fish) divided by the body weight | + | '''Lifetime cancer risk''' associated with PCDD/Fs is usually estimated using cancer slope factor (CSF) and the lifetime average daily dose (LADD). Therefore, in this case the intake of PCDD/Fs from fish is expressed as LADD. LADD is calculated as a product of average daily dose (ADD) and the ratio of exposure duration and lifetime, where ADD is the product of concentration of PCDD/Fs in fish and fish intake rate (daily intake of fish) divided by the body weight. |
It is assumed that the exposure duration for people from a given age group is the number of years this age group covers. In other words it is assumed that people from a given age group are exposed to PCDD/Fs from the time of entry to this age group until the time of exit from this age group. For example the exposure duration for age group 18-55yr is 37 years. <br> | It is assumed that the exposure duration for people from a given age group is the number of years this age group covers. In other words it is assumed that people from a given age group are exposed to PCDD/Fs from the time of entry to this age group until the time of exit from this age group. For example the exposure duration for age group 18-55yr is 37 years. <br> | ||
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Moreover, the average lifetime is 82.9 and 75.9 for Finnish women and men, respectively<ref>http://www.stat.fi/tup/suoluk/suoluk_vaesto_en.html</ref>. | Moreover, the average lifetime is 82.9 and 75.9 for Finnish women and men, respectively<ref>http://www.stat.fi/tup/suoluk/suoluk_vaesto_en.html</ref>. | ||
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| + | To evaluate '''non-cancer risks''' the average daily dose (ADD) of PCDD/Fs is used. For children, the ADD of PCDD/Fs from fish is estimated as a product of daily fish consumption and | ||
| + | the average WHO-TEQ concentration of PCDD/Fs in fish divided by the body weight. | ||
=== Formula === | === Formula === | ||
| − | + | ADD_species(i)=Average_WHO-TEQ_PCDD/Fs_Concentration_species(i)*Daily_Consumption_species(i)/BW | |
=== Unit === | === Unit === | ||
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| + | '''ADD''': pg WHO-TEQ/kg bw-day | ||
== See also == | == See also == | ||
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== Result == | == Result == | ||
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Revision as of 10:51, 7 September 2009
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Scope
Intake of PCDD/Fs from fish describes the exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) due to fish consumption in the Beneris population.
Definition
Intake of PCDD/F from fish in Beneris is represented as a continuous variable and is indexed by variable age. It applies to the whole Beneris population (all age groups 0-2yr, 2-18yr, 18-55yr and 55yr+) and to indicators such as remaining lifetime risk of cancer in adults and risk of developmental dental defects.
Causality
List of parents:
- Concentrations of PCDD/Fs in fish
- Domestic fish consumption of the general population in Finland
- Body weight in Finland
Data
Lifetime cancer risk associated with PCDD/Fs is usually estimated using cancer slope factor (CSF) and the lifetime average daily dose (LADD). Therefore, in this case the intake of PCDD/Fs from fish is expressed as LADD. LADD is calculated as a product of average daily dose (ADD) and the ratio of exposure duration and lifetime, where ADD is the product of concentration of PCDD/Fs in fish and fish intake rate (daily intake of fish) divided by the body weight.
It is assumed that the exposure duration for people from a given age group is the number of years this age group covers. In other words it is assumed that people from a given age group are exposed to PCDD/Fs from the time of entry to this age group until the time of exit from this age group. For example the exposure duration for age group 18-55yr is 37 years.
Moreover, the average lifetime is 82.9 and 75.9 for Finnish women and men, respectively[1].
To evaluate non-cancer risks the average daily dose (ADD) of PCDD/Fs is used. For children, the ADD of PCDD/Fs from fish is estimated as a product of daily fish consumption and
the average WHO-TEQ concentration of PCDD/Fs in fish divided by the body weight.
Formula
ADD_species(i)=Average_WHO-TEQ_PCDD/Fs_Concentration_species(i)*Daily_Consumption_species(i)/BW
Unit
ADD: pg WHO-TEQ/kg bw-day
See also
TemaNord report on PCDD/F and PCB in Nordic countries
