Difference between revisions of "Myocardial infarction risk in adults in Beneris"

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'''Scope'''<br>
 
'''Scope'''<br>
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'''Myocardial infarction risk in adults''' describes the remaining lifetime risk of having a myocardial infarction in adults as a result of exposure to methyl mercury, selenium and fish oils through fish consumption in the target European country.
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'''Myocardial infarction risk in adults in Beneris''' describes the relationship between exposure to omega-3 fatty acids (EPA+DHA) and methyl mercury (MeHg) in fish and the mortality from coronary heart disease (CHD) in adult Beneris population.
  
 
== Definition ==  
 
== Definition ==  
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Myocardial infarction in adults is represented as a function of parent variables and is indexed by variable age. It applies to last two age categories and to adults in general (individuals aged 18 years and older).   
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'''Myocardial infarction in adults''' is represented as a function of parent variables and is indexed by variable age. It applies to two age groups, i.e adults aged 18-55yr and 55yr+ (gender combined).   
  
 
=== Causality ===  
 
=== Causality ===  
 
List of parents:
 
List of parents:
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*[[Variable:Fish oil intake]]
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*[[Mortality in Finland]] - represents baseline CHD mortality in Finland
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*[[Variable:Selenium intake from fish]]
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*[[Fish oil intake in Beneris]]
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*[[Variable:MeHg intake from fish]]
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*[[Methyl mercury intake from fish in Beneris]]
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*[[Variable:Socio-economic status]]
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*[[ERF of omega-3 fatty acids on CVD risk in adults ]]
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*[[Variable:Smoking status]]
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*[[ERF of methyl mercury on CVD risk in adults]]
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*[[Variable:Exposure-response of fish oil intake for MI risk in adults]]
 
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*[[Variable:Exposure-response of Se intake for MI risk in adults]]
 
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*[[Variable:Exposure-response of MeHg intake for MI risk in adults]]
 
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*[[Variable:Exposure-response of MeHg and Se interaction for MI risk in adults]]
 
  
 
=== Data ===  
 
=== Data ===  
  
 
=== Formula ===  
 
=== Formula ===  
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*the (remaining) lifetime risk of myocardial infarction for adults between 18 and 55 years of age:
 
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MI_risk_18_55yr = 1/(1+e^(-(0.5-0.0006*37*(fatty_acids18_55-16)+0.003*37*(mehg18_55-37)-0.0005*37*(selenium18_55-0.29)-0.03*(socioeconomic_status18_55-8)+
 
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0.01*37*(smoking_status18_55-2.023)-0.0005*37*37*(mehg18_55-37)*(selenium18_55-0.29))))
 
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*the (remaining) lifetime risk of myocardial infarction for adults older than 55 years:
 
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MI_risk_over55yr = 1/(1+e^(-(0.55-0.0037*20*(fatty_acids55-15)+0.003*20*(mehg55-31)-0.0037*20*(selenium55-0.24)-0.005*(socioeconomic_status55-10)+
 
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0.03*20*(smoking_status55-2.023)-0.00037*20*20*(mehg55-31)*(selenium55-0.24))))
 
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*the (remaining) lifetime risk of myocardial infarction for adults older than 18 years:
 
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MI_risk = 0.6*MI_risk_18_55yr+0.4*MI_risk_over55yr
 
  
 
=== Unit ===  
 
=== Unit ===  
  
 
== Result ==
 
== Result ==

Revision as of 08:26, 15 September 2009

Scope
Myocardial infarction risk in adults in Beneris describes the relationship between exposure to omega-3 fatty acids (EPA+DHA) and methyl mercury (MeHg) in fish and the mortality from coronary heart disease (CHD) in adult Beneris population.

Definition

Myocardial infarction in adults is represented as a function of parent variables and is indexed by variable age. It applies to two age groups, i.e adults aged 18-55yr and 55yr+ (gender combined).

Causality

List of parents:

Data

Formula

Unit

Result

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