Organochlorine insecticides

From Testiwiki
Jump to: navigation, search
The text on this page is taken from an equivalent page of the IEHIAS-project.
  • The use of organochlorine insecticides was discontinued after the 1960s due to their persistent contamination.
  • However, they can still be detected in biological samples.
  • Nine organochlorines (aldrin, chlordane, DDT, dieldrin, endrin, heptachlor, hexachlorobenzene, mirex and toxaphene) are subject of the Stockholm Convention on POPs

Organochlorine insecticides as biomarkers

Sample collection and storage


  • Biological monitoring can be carried out in blood, fatty tissue and urine


  • Uptake through inhalation, dermal uptake or ingestion
  • Detoxification through induction of cytochrome P450 activates organochlorines to genotoxic species

Sampling conditions:

  • Standard sampling procedures should be taken into account
  • Since a significant number of compounds may be present in the general “unexposed” population, pre-exposure sampling is recommended for comparison with post-exposure levels

Sample measurement

Analytical aspects:

  • Serum or plasma is extracted using liquid or solid-phase extraction and analyzed using GC and ECD or MS
  • Comparable methods are used for other lipid rich matrices such as adipose tissue or breast milk
  • Metabolites in urine can be detected in the ng/l level in urine using SPE and GC-MS-MS

Performance characteristics:

No data available


No data available

Confounding factors:

No data available

Data interpretation

Concentrations reported in literature:

No data available

Dose-response/effect relationships:

  • Organochlorine insecticides are linked with STS, non-Hodgkin’s lymphoma, leukemia and, less consistently, with lung and breast cancers.
  • They may also affect fertility mechanisms at relatively low levels (0.41 ng/ml)

Time trend, geographical variation, susceptibel groups:

No data available

See also

Integrated Environmental Health Impact Assessment System
IEHIAS is a website developed by two large EU-funded projects Intarese and Heimtsa. The content from the original website was moved to Opasnet.
Topic Pages

Boundaries · Population: age+sex 100m LAU2 Totals Age and gender · ExpoPlatform · Agriculture emissions · Climate · Soil: Degredation · Atlases: Geochemical Urban · SoDa · PVGIS · CORINE 2000 · Biomarkers: AP As BPA BFRs Cd Dioxins DBPs Fluorinated surfactants Pb Organochlorine insecticides OPs Parabens Phthalates PAHs PCBs · Health: Effects Statistics · CARE · IRTAD · Functions: Impact Exposure-response · Monetary values · Morbidity · Mortality: Database

Examples and case studies Defining question: Agriculture Waste Water · Defining stakeholders: Agriculture Waste Water · Engaging stakeholders: Water · Scenarios: Agriculture Crop CAP Crop allocation Energy crop · Scenario examples: Transport Waste SRES-population UVR and Cancer
Models and methods Ind. select · Mindmap · Diagr. tools · Scen. constr. · Focal sum · Land use · Visual. toolbox · SIENA: Simulator Data Description · Mass balance · Matrix · Princ. comp. · ADMS · CAR · CHIMERE · EcoSenseWeb · H2O Quality · EMF loss · Geomorf · UVR models · INDEX · RISK IAQ · CalTOX · PANGEA · dynamiCROP · IndusChemFate · Transport · PBPK Cd · PBTK dioxin · Exp. Response · Impact calc. · Aguila · Protocol elic. · Info value · DST metadata · E & H: Monitoring Frameworks · Integrated monitoring: Concepts Framework Methods Needs
Listings Health impacts of agricultural land use change · Health impacts of regulative policies on use of DBP in consumer products
Guidance System
The concept
Issue framing Formulating scenarios · Scenarios: Prescriptive Descriptive Predictive Probabilistic · Scoping · Building a conceptual model · Causal chain · Other frameworks · Selecting indicators
Design Learning · Accuracy · Complex exposures · Matching exposure and health · Info needs · Vulnerable groups · Values · Variation · Location · Resolution · Zone design · Timeframes · Justice · Screening · Estimation · Elicitation · Delphi · Extrapolation · Transferring results · Temporal extrapolation · Spatial extrapolation · Triangulation · Rapid modelling · Intake fraction · iF reading · Piloting · Example · Piloting data · Protocol development
Execution Causal chain · Contaminant sources · Disaggregation · Contaminant release · Transport and fate · Source attribution · Multimedia models · Exposure · Exposure modelling · Intake fraction · Exposure-to-intake · Internal dose · Exposure-response · Impact analysis · Monetisation · Monetary values · Uncertainty